(Q34650716)

3 August 2017

1 reference

18 October 2020

1 reference

systematic review

1 reference

title

MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features (English)

1 reference

signal transducing adaptor protein

3 August 2017

1 reference

18 October 2020

1 reference

28 November 2019

1 reference

19 December 2019

1 reference

4 September 2020

1 reference

18 October 2020

1 reference

Fan Wang

5

0 references

author name string

Xia Li

1

1 reference

3 August 2017

Xiaoping Yao

2

1 reference

3 August 2017

Yibaina Wang

3

1 reference

3 August 2017

Fulan Hu

4

1 reference

3 August 2017

Liying Jiang

6

1 reference

3 August 2017

Yupeng Liu

7

1 reference

3 August 2017

Da Wang

8

1 reference

3 August 2017

Guizhi Sun

9

1 reference

3 August 2017

Yashuang Zhao

10

1 reference

3 August 2017

language of work or name

English

0 references

publication date

29 March 2013

8 references

3 August 2017

21 March 2019

3 April 2019

20 November 2019

28 November 2019

19 December 2019

4 September 2020

18 October 2020

8 references

3 August 2017

21 March 2019

3 April 2019

20 November 2019

28 November 2019

19 December 2019

4 September 2020

18 October 2020

8

1 reference

3 August 2017

issue

3

1 reference

3 August 2017

page(s)

e59064

1 reference

Creative Commons Attribution 4.0 International

3 August 2017

copyright license

7 references

21 March 2019

3 April 2019

20 November 2019

28 November 2019

19 December 2019

4 September 2020

on focus list of Wikimedia project

18 October 2020

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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7 July 2018

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Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening

7 July 2018

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Clinicopathological characteristics of colorectal cancer with family history: an evaluation of family history as a predictive factor for microsatellite instability

7 July 2018

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Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer

7 July 2018

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Methylation analysis of hMLH1 gene promoter by a bisulfite-sensitive single-strand conformation polymorphism-capillary electrophoresis method

7 July 2018

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The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers

7 July 2018

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Colorectal cancer "methylator phenotype": fact or artifact?

7 July 2018

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7 July 2018

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CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype.

7 July 2018

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A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

7 July 2018

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Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status

7 July 2018

1 reference

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Epigenetic changes in colorectal cancer.

7 July 2018

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Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability

7 July 2018

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BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer

7 July 2018

1 reference

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High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas.

7 July 2018

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Measuring inconsistency in meta-analyses

7 July 2018

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Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability

7 July 2018

1 reference

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7 July 2018

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Microsatellite instability and the clinicopathological features of sporadic colorectal cancer

7 July 2018

1 reference

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Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features

7 July 2018

1 reference

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7 July 2018

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7 July 2018

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7 July 2018

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Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression.

7 July 2018

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A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

7 July 2018

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Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

7 July 2018

1 reference

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Bias in meta-analysis detected by a simple, graphical test

7 July 2018

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Genetic instability in colorectal cancers

7 July 2018

1 reference

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Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

7 July 2018

1 reference

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Microsatellite instability in cancer of the proximal colon

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

Clues to the pathogenesis of familial colorectal cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

Operating characteristics of a rank correlation test for publication bias

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

Meta-analysis in clinical trials

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

The essentials of DNA methylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

Evidence of a preferred molecular pathway in patients with synchronous colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

The mechanism of microsatellite instability is different in synchronous and metachronous colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

21 January 2018

1 reference

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Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified

21 January 2018

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Meta-analysis in the design and monitoring of clinical trials.

21 January 2018

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Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability.

21 January 2018

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MLH1 promoter methylation, diet, and lifestyle factors in mismatch repair deficient colorectal cancer patients from EPIC-Norfolk.

21 January 2018

1 reference

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Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer

21 January 2018

1 reference

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Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines

26 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

Tumorigenesis in colorectal tumors from patients with hereditary non-polyposis colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

Causes of microsatellite instability in colorectal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059064

Identification in Daily Practice of Patients With Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer): Revised Bethesda Guidelines-Based ApproachVersusMolecular Screening

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3612054

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

9 December 2018

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12 December 2020

Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer

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12 December 2020

TNM Classification of Malignant Tumors, fifth edition (1997). Union Internationale Contre le Cancer and the American Joint Committee on Cancer

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12 December 2020

Methylation variable position profiles of hMLH1 promoter CpG islands in human sporadic colorectal carcinoma

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12 December 2020

Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer

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12 December 2020

Methylation pattern of different regions of theMLH1 promoter and silencing of gene expression in hereditary and sporadic colorectal cancer

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12 December 2020

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12 December 2020

Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation

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12 December 2020

CpG island methylator phenotype in cancer

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12 December 2020

Mechanisms of microsatellite instability in colorectal cancer patients in different age groups

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12 December 2020

APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer

1 reference

12 December 2020

Methylation of serum DNA is an independent prognostic marker in colorectal cancer

1 reference

12 December 2020

Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0059064

Identifiers

DOI

1 reference

3 August 2017

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1 reference

3 August 2017

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