(Q34651613)

3 August 2017

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title

WNK4-mediated regulation of renal ion transport proteins (English)

1 reference

3 August 2017

Ji-Bin Peng

1

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3 August 2017

David G Warnock

series ordinal

2

1 reference

3 August 2017

publication date

18 July 2007

1 reference

American Journal of Physiology - Renal Physiology

3 August 2017

published in

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3 August 2017

volume

293

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3 August 2017

issue

4

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3 August 2017

page(s)

F961-73

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WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells

3 August 2017

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WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells

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Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

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WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia

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TRPV4 and the mammalian kidney

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WNK kinases and the control of blood pressure

21 January 2018

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WNK1 affects surface expression of the ROMK potassium channel independent of WNK4

21 January 2018

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Immunocytochemical localization of the cystic fibrosis gene product CFTR

21 January 2018

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WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway

21 January 2018

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Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression

21 January 2018

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Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform

21 January 2018

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Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2.

21 January 2018

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SPAK and OSR1, key kinases involved in the regulation of chloride transport

21 January 2018

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Developmental regulation of CFTR expression during human nephrogenesis.

21 January 2018

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Genetic variants of WNK4 in whites and African Americans with hypertension

21 January 2018

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WNK4 regulates airway Na+ transport: study of familial hyperkalaemia and hypertension

21 January 2018

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WNK kinases influence TRPV4 channel function and localization

21 January 2018

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Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4.

21 January 2018

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Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters.

21 January 2018

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Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells.

21 January 2018

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WNK4 kinase is a negative regulator of K+-Cl- cotransporters.

21 January 2018

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Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.

21 January 2018

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A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Familial hyperkalemic hypertension

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Life and death of the distal nephron: WNK4 and NCC as major players

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Intersectin links WNK kinases to endocytosis of ROMK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3).

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Study of claudin function by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK kinases: molecular regulators of integrated epithelial ion transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Cystic fibrosis transmembrane conductance regulator-dependent up-regulation of Kir1.1 (ROMK) renal K+ channels by the epithelial sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Properties of WNK1 and implications for other family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Molecular mechanisms of human hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Hypokalemia in a mouse model of Gitelman's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Mitogenesis and endocytosis: What's at the INTERSECTIoN?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Structural conservation of the genes encoding CaT1, CaT2, and related cation channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Type 2 pseudohypoaldosteronism: new insights into renal potassium, sodium, and chloride handling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Novel subunit composition of a renal epithelial KATP channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

CFTR is a conductance regulator as well as a chloride channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

CFTR as a cAMP-dependent regulator of sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

CFTR expression in cortical collecting duct cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK1 kinase isoform switch regulates renal potassium excretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Genetic forms of human hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Human hypertension caused by mutations in WNK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Cystic fibrosis transmembrane conductance regulator in the kidney: clues to its role?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Trp12, a novel Trp related protein from kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK1 activates SGK1 to regulate the epithelial sodium channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Genome-wide detection of tissue-specific alternative splicing in the human transcriptome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK kinases regulate thiazide-sensitive Na-Cl cotransport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

WNK1 and WNK4 modulate CFTR activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00192.2007

10.1152/AJPRENAL.00192.2007

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference