(Q34660416)

3 August 2017

1 reference

title

Flavonoid modulation of GABA(A) receptors (English)

1 reference

3 August 2017

Jane R Hanrahan

1

1 reference

3 August 2017

Mary Chebib

series ordinal

2

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3 August 2017

Graham A R Johnston

series ordinal

3

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3 August 2017

language of work or name

English

0 references

publication date

1 May 2011

1 reference

British Journal of Pharmacology

3 August 2017

published in

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3 August 2017

volume

163

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3 August 2017

issue

2

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3 August 2017

page(s)

234-245

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Insights into the structure and pharmacology of GABA(A) receptors

3 August 2017

cites work

1 reference

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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GABA A receptors: subtypes provide diversity of function and pharmacology

7 July 2018

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GABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer

7 July 2018

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General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

7 July 2018

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Cancer phytotherapeutics: role for flavonoids at the cellular level

7 July 2018

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An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models

7 July 2018

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Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis

7 July 2018

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6,2'-Dihydroxyflavone, a subtype-selective partial inverse agonist of GABAA receptor benzodiazepine site

7 July 2018

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Neurosteroid binding sites on GABA(A) receptors

7 July 2018

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Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries

7 July 2018

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Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

7 July 2018

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Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG).

7 July 2018

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Identification of structures within GABAA receptor alpha subunits that regulate the agonist action of pentobarbital

7 July 2018

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GABA-based therapeutic approaches: GABAA receptor subtype functions

7 July 2018

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GABA-A receptors: a viable target for novel anxiolytics?

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Antimicrobial activity of flavonoids

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Determinants of amentoflavone interaction at the GABA(A) receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

GABA(A) receptor channel pharmacology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

The benzodiazepine binding site of GABA A receptors as a target for the development of novel anxiolytics

7 July 2018

1 reference

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Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit.

7 July 2018

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GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures

7 July 2018

1 reference

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Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Molecular and neuronal substrates for general anaesthetics

7 July 2018

1 reference

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The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects

7 July 2018

1 reference

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Polyphenols: food sources and bioavailability

7 July 2018

1 reference

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Flavonoids: antioxidants or signalling molecules?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Metamodulation of the biogenic amines: second-order modulation by steroid hormones and amine cocktails

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Transport of amentoflavone across the blood-brain barrier in vitro

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

GABA(A)-receptor ligands of flavonoid structure

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory tasks in rats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

7 July 2018

1 reference

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Alpha subunit isoform influences GABA(A) receptor modulation by propofol

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum.

7 July 2018

1 reference

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Overview--flavonoids: a new family of benzodiazepine receptor ligands.

7 July 2018

1 reference

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Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination

7 July 2018

1 reference

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6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Isolation and Identification of "Diazepam-Like" Compounds From Bovine Urine

7 July 2018

1 reference

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Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

A single histidine in GABAA receptors is essential for benzodiazepine agonist binding

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Plasma concentrations of benzodiazepines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

(-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain.

7 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Synergistic interaction between hesperidin, a natural flavonoid, and diazepam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors

21 January 2018

1 reference

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(+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Pharmacological studies on synthetic flavonoids: comparison with diazepam.

21 January 2018

1 reference

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Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes.

21 January 2018

1 reference

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3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors

21 January 2018

1 reference

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Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Behavioral effects of 6-bromoflavanone and 5-methoxy-6,8-dibromoflavanone as anxiolytic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

GABA(A) receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Biflavones from Rhus species with affinity for the GABA(A)/benzodiazepine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Pharmacological characterization of 6-bromo-3'-nitroflavone, a synthetic flavonoid with high affinity for the benzodiazepine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Behavioral characterisation of the flavonoids apigenin and chrysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Guide to Receptors and Channels (GRAC), 4th Edition

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Flavonoids from Leptospermum scoparium with affinity to the benzodiazepine receptor characterized by structure activity relationships and in vivo studies of a plant extract.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Development of a comprehensive pharmacophore model for the benzodiazepine receptor.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087128

Compounds from Mentha aquatica with affinity to the GABA-benzodiazepine receptor

26 October 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01228.X

Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla

21 January 2018

1 reference

12 December 2020

Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex

1 reference

12 December 2020

Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds

1 reference

12 December 2020

High affinity of the naturally-occurring biflavonoid, amentoflavon, to brain benzodiazepine receptors in vitro

1 reference

12 December 2020

10.1111/J.1476-5381.2011.01228.X

Identifiers

DOI

1 reference

3 August 2017

1 reference

3 August 2017

1 reference