(Q34365717)

1 August 2017

1 reference

title

GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures (English)

1 reference

1 August 2017

Myles H Akabas

1

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publication date

1 January 2004

1 reference

International Review of Neurobiology

1 August 2017

published in

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1 August 2017

volume

62

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1 August 2017

page(s)

1-43

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Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.

1 August 2017

cites work

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7 January 2021

Aquaporin water channels--from atomic structure to clinical medicine

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7 January 2021

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit.

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7 January 2021

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

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7 January 2021

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

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7 January 2021

Analysis of zinc binding sites in protein crystal structures

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7 January 2021

GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.

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7 January 2021

Life at the top: the transition state of AChR gating

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7 January 2021

Zinc coordination sphere in biochemical zinc sites.

1 reference

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7 January 2021

The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Defining the propofol binding site location on the GABAA receptor

1 reference

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7 January 2021

Subunit arrangement of gamma-aminobutyric acid type A receptors

1 reference

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7 January 2021

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

General anaesthetic action at transmitter-gated inhibitory amino acid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.

1 reference

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7 January 2021

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mutation of the 9' leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Spontaneously opening GABA(A) channels in CA1 pyramidal neurones of rat hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The steroid promegestone is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor that interacts with the lipid-protein interface.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mapping the agonist binding site of the GABAA receptor: evidence for a beta-strand.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Effects of gamma2S subunit incorporation on GABAA receptor macroscopic kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The 'ABC' of GABA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Multiple roles of protein kinases in the modulation of gamma-aminobutyric acid(A) receptor function and cell surface expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Two novel residues in M2 of the gamma-aminobutyric acid type A receptor affecting gating by GABA and picrotoxin affinity.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Role of the putative transmembrane segment M3 in gating of neuronal nicotinic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Multiphasic desensitization of the GABAA receptor in outside-out patches

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Stoichiometry of a recombinant GABAA receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Substitutions of the highly conserved M2 leucine create spontaneously opening rho1 gamma-aminobutyric acid receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Channel opening locks agonist onto the GABAC receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Identifying the cholesterol binding domain in the nicotinic acetylcholine receptor with [125I]azido-cholesterol

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Proline-induced distortions of transmembrane helices.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Nicotinic receptors at the amino acid level

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Anxiety over GABA(A) receptor structure relieved by AChBP.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Nicotinic receptor M3 transmembrane domain: position 8' contributes to channel gating

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The effects of general anaesthetics on ligand-gated ion channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Hippocampal GABA(A) channel conductance increased by diazepam

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Point mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gating

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Molecular composition of GABAC receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Comparative modeling of GABA(A) receptors: limits, insights, future developments.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Anion permeation in GABA- and glycine-gated channels of mammalian cultured hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

A point mutation in a Drosophila GABA receptor confers insecticide resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Single channel properties of recombinant GABAA receptors containing gamma 2 or delta subtypes expressed with alpha 1 and beta 3 subtypes in mouse L929 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The role of an alpha subtype M2-M3 His in regulating inhibition of GABAA receptor current by zinc and other divalent cations

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Molecular and cellular mechanisms of general anaesthesia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The effects of a point mutation of the beta2 subunit of GABA(A) receptor on direct and modulatory actions of general anesthetics

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Zn2+ inhibition of recombinant GABAA receptors: an allosteric, state-dependent mechanism determined by the gamma-subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The dissociation of acetylcholine from open nicotinic receptor channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The extracellular linker of muscle acetylcholine receptor channels is a gating control element

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mapping the conformational wave of acetylcholine receptor channel gating

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Tryptophan scanning mutagenesis in the alphaM3 transmembrane domain of the Torpedo californica acetylcholine receptor: functional and structural implications

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Kinetics of the reaction of p-chloromercuribenzoate with the sulfhydryl groups of glutathione, 2-mercaptoethanol, and phosphorylase b

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Actions of the insecticide fipronil, on dieldrin‐sensitive and ‐resistant GABA receptors of Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Chloride Channel Expression with the Tandem Construct of α6-β2 GABAA Receptor Subunit Requires a Monomeric Subunit of α6 or γ2

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Microscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Defining affinity with the GABAA receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Desensitized states prolong GABAA channel responses to brief agonist pulses.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Whole-cell and single-channel currents activated by GABA and glycine in granule cells of the rat cerebellum

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Emerging structure of the nicotinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Substituted-cysteine accessibility method

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Coupling of agonist binding to channel gating in the GABA(A) receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Conductance mutations of the nicotinic acetylcholine receptor do not act by a simple electrostatic mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Acetylcholine receptor gating is influenced by the polarity of amino acids at position 9' in the M2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

General anaesthetic actions on ligand-gated ion channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Direct evidence for diazepam modulation of GABAA receptor microscopic affinity.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The permeation pathway of neurotransmitter-gated ion channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Cell-free expression and functional reconstitution of homo-oligomeric alpha7 nicotinic acetylcholine receptors into planar lipid bilayers

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The surface accessibility of the glycine receptor M2-M3 loop is increased in the channel open state.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

GABAA receptor channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

How quickly can GABAA receptors open?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The pharmacology of spontaneously open alpha 1 beta 3 epsilon GABA A receptor-ionophores

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

GABAB receptors - the first 7TM heterodimers.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The GABAA receptor: new insights from single-channel recording

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Genetic manipulation of ion channels: a new approach to structure and mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Molecular and basic mechanisms of anaesthesia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wall.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Structure and gating mechanism of the acetylcholine receptor pore

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Single channel analysis of conductance and rectification in cation-selective, mutant glycine receptor channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Constructing inhibitory synapses

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Quaternary structure of the native GABAA receptor determined by electron microscopic image analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Tyrosine 62 of the gamma-aminobutyric acid type A receptor beta 2 subunit is an important determinant of high affinity agonist binding

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Proline-induced disruption of a transmembrane alpha-helix in its natural environment.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Structural homology of Torpedo californica acetylcholine receptor subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Arg-274 and Leu-277 of the gamma-aminobutyric acid type A receptor alpha 2 subunit define agonist efficacy and potency

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Slow desensitization regulates the availability of synaptic GABA(A) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Agonist-induced closure of constitutively open gamma-aminobutyric acid channels with mutated M2 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Evidence for a centrally located gate in the pore of a serotonin-gated ion channel.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Multiple residues specify external tetraethylammonium blockade in voltage-gated potassium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Interaction of non-competitive blockers within the gamma-aminobutyric acid type A chloride channel using chemically reactive probes as chemical sensors for cysteine mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic ACh receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

From ion currents to genomic analysis: recent advances in GABAA receptor research.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review)

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Prediction of 5-HT3 receptor agonist-binding residues using homology modeling.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Protein design: novel metal-binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

A residue in the middle of the M2-M3 loop of the beta4 subunit specifically affects gating of neuronal nicotinic receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Gating of alpha3beta4 neuronal nicotinic receptor can be controlled by the loop M2-M3 of both alpha3 and beta4 subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

GABA(A) receptor subtypes: dissecting their pharmacological functions

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Assembly of GABAA receptor subunits: role of the delta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

A single beta subunit M2 domain residue controls the picrotoxin sensitivity of alphabeta heteromeric glycine receptor chloride channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Subunit composition, distribution and function of GABA(A) receptor subtypes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mapping of the benzodiazepine recognition site on GABA(A) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Differential effect of zinc on the vertebrate GABAA-receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

GABAA receptors are differentially sensitive to zinc: dependence on subunit composition

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

A glia-derived acetylcholine-binding protein that modulates synaptic transmission.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Effects of mutating leucine to threonine in the M2 segment of alpha1 and beta1 subunits of GABAA alpha1beta1 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Effects of substitution of putative transmembrane segments on nicotinic acetylcholine receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Stoichiometry and assembly of a recombinant GABAA receptor subtype.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Pentobarbital and picrotoxin have reciprocal actions on single GABAA receptor channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Intraburst kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Etomidate potentiation of GABAA receptor gated current depends on the subunit composition.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Nicotinic acetylcholine receptor at 9 A resolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Acetylcholine receptor channel imaged in the open state

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Proline kinks in transmembrane alpha-helices

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Cation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Gating scheme for single GABA-activated Cl- channels determined from stability plots, dwell-time distributions, and adjacent-interval durations

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Identification of a beta subunit TM2 residue mediating proton modulation of GABA type A receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Evidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

The location of the gate in the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

GABAA receptor channels: from subunits to functional entities

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Identification of a Zn2+ binding site on the murine GABAA receptor complex: dependence on the second transmembrane domain of beta subunits.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Pharmacological and physiological characterization of murine homomeric beta3 GABA(A) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Permeability and single channel conductance of human homomeric rho1 GABAC receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Mutations at the GABA receptor selectivity filter: a possible role for effective charges

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Anesthetics and ion channels: molecular models and sites of action

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the beta-subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

A single point mutation decreases picrotoxinin sensitivity of the human GABA receptor ρ1 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

Kinetic properties and regulation of GABAA receptor channels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2804%2962001-0

7 January 2021

10.1016/S0074-7742(04)62001-0

Identifiers

DOI

1 reference

1 August 2017

1 reference