(Q34660713)

3 August 2017

1 reference

title

General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage (English)

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3 August 2017

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3

Robert M Sapolsky

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3 August 2017

2

Gary K Steinberg

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3 August 2017

Heng Zhao

1

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3 August 2017

publication date

8 August 2007

1 reference

Journal of Cerebral Blood Flow & Metabolism

3 August 2017

published in

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3 August 2017

volume

27

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3 August 2017

issue

12

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3 August 2017

page(s)

1879-1894

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Effect of intra-ischemic hypothermia on the expression of c-Fos and c-Jun, and DNA binding activity of AP-1 after focal cerebral ischemia in rat brain.

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Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation

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Moderate hypothermia reduces postischemic edema development and leukotriene production.

21 January 2018

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Therapeutic hypothermia in acute ischemic stroke

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Combination of decompressive craniectomy and mild hypothermia ameliorates infarction volume after permanent focal ischemia in rats.

21 January 2018

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The effect of hypothermia on the expression of the apoptosis-regulating protein Bax after incomplete cerebral ischemia and reperfusion in rats

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Intraischemic but not postischemic hypothermia prevents non-selective hippocampal downregulation of AMPA and NMDA receptor gene expression after global ischemia.

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21 January 2018

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Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia.

21 January 2018

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Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke.

21 January 2018

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Hypothermia inhibits translocation of CaM kinase II and PKC-alpha, beta, gamma isoforms and fodrin proteolysis in rat brain synaptosome during ischemia-reperfusion.

21 January 2018

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Postischemic hypothermia inhibits the generation of hydroxyl radical following transient forebrain ischemia in rats

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Comparative neuroprotective efficacy of prolonged moderate intraischemic and postischemic hypothermia in focal cerebral ischemia

21 January 2018

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Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest

21 January 2018

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Intraischemic mild hypothermia increases hippocampal CA1 blood flow during forebrain ischemia

21 January 2018

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21 January 2018

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21 January 2018

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Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of cooling

21 January 2018

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Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats

21 January 2018

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Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood-brain barrier disruption, brain edema, and neuronal damage volume after temporary focal cerebral ischemia in rats

21 January 2018

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Effects of delayed intraischemic and postischemic hypothermia on a focal model of transient cerebral ischemia in rats

21 January 2018

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Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.

21 January 2018

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Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia.

21 January 2018

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Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil

21 January 2018

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The combination of lamotrigine and mild hypothermia prevents ischemia-induced increase in hippocampal glutamate

21 January 2018

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Lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia

21 January 2018

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Effect of temperature in focal ischemia of rat brain studied by 31P and 1H spectroscopic imaging.

21 January 2018

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Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us?

21 January 2018

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The influence of moderate hypothermia on cellular calcium uptake in complete ischaemia: implications for the excitotoxic hypothesis

21 January 2018

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Expression of c-fos and fos-B proteins following transient forebrain ischemia: effect of hypothermia.

21 January 2018

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Hypothermia ameliorates ischemic brain damage and suppresses the release of extracellular amino acids in both normo- and hyperglycemic subjects.

21 January 2018

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Delayed moderate hypothermia reduces calpain activity and breakdown of its substrate in experimental focal cerebral ischemia in rats

21 January 2018

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Impaired DNA repair via the base-excision repair pathway after focal ischemic brain injury: a protein phosphorylation-dependent mechanism reversed by hypothermic neuroprotection.

21 January 2018

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Mineralocorticoid receptor expression and increased survival following neuronal injury

21 January 2018

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21 January 2018

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Aggravation of brain injury after transient focal ischemia in p53-deficient mice

21 January 2018

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Effects of mild hypothermia on superoxide anion production, superoxide dismutase expression, and activity following transient focal cerebral ischemia

21 January 2018

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Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size

21 January 2018

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Mild hypothermia decreases the incidence of transient ADC reduction detected with diffusion MRI and expression of c-fos and hsp70 mRNA during acute focal ischemia in rats

21 January 2018

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Temperature dependence of hypoxia-induced calcium accumulation in gerbil hippocampal slices

21 January 2018

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Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: Brain microdialysis study

21 January 2018

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Temporal profile of changes in brain tissue extracellular space and extracellular ion (Na(+), K(+)) concentrations after cerebral ischemia and the effects of mild cerebral hypothermia.

21 January 2018

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The significance of brain temperature in focal cerebral ischemia: histopathological consequences of middle cerebral artery occlusion in the rat

21 January 2018

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Spontaneous cerebral hypothermia diminishes focal infarction in rat brain

21 January 2018

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Effects of hypothermia, pentobarbital, and isoflurane on postdepolarization amino acid release during complete global cerebral ischemia.

21 January 2018

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Characterization of cortical depolarizations evoked in focal cerebral ischemia.

21 January 2018

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Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy

21 January 2018

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Therapeutic time window of post-ischemic mild hypothermia and the gene expression associated with the neuroprotection in rat focal cerebral ischemia.

21 January 2018

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Profiles of cortical tissue depolarization in cat focal cerebral ischemia in relation to calcium ion homeostasis and nitric oxide production

21 January 2018

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Differential temperature sensitivity of ischemia-induced glutamate release and eicosanoid production in rats

21 January 2018

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Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate

21 January 2018

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A two-hour window for hypothermic modulation of early events that impact delayed opening of the rat blood-brain barrier after ischemia

21 January 2018

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Hypothermic protection in rat focal ischemia models: strain differences and relevance to "reperfusion injury".

21 January 2018

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Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats

21 January 2018

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Matrix metalloproteinases in neuroinflammation

21 January 2018

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Glutamate release in severe brain ischaemia is mainly by reversed uptake.

21 January 2018

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Different effects of hypothermia on amino acid incorporation and on amino acid uptake in the brain in vivo

21 January 2018

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Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.

21 January 2018

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Effect of brain, body, and magnet bore temperatures on energy metabolism during global cerebral ischemia and reperfusion monitored by magnetic resonance spectroscopy in rats.

21 January 2018

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Epsilon PKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model.

21 January 2018

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Effect of hypothermia on brain multi-parametric activities in normoxic and partially ischemic rats.

21 January 2018

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Exacerbation of traumatically induced axonal injury by rapid posthypothermic rewarming and attenuation of axonal change by cyclosporin A.

21 January 2018

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Consecutive in vivo measurement of nitric oxide in transient forebrain ischemic rat under normothermia and hypothermia.

21 January 2018

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Global cerebral ischemia in piglets under conditions of mild and deep hypothermia.

21 January 2018

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Quantitative evaluation of the neuroprotective effects of hypothermia ranging from 34 degrees C to 31 degrees C on brain ischemia in gerbils and determination of the mechanism of neuroprotection.

21 January 2018

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Hypothermia attenuates the activation of protein kinase C in focal ischemic rat brain: dual autoradiographic study of [3H]phorbol 12,13-dibutyrate and iodo[14C]antipyrine.

21 January 2018

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The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia.

21 January 2018

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The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

21 January 2018

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Intraischemic hypothermia attenuates neutrophil infiltration in the rat neocortex after focal ischemia-reperfusion injury

21 January 2018

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Uncomplicated rapid posthypothermic rewarming alters cerebrovascular responsiveness

21 January 2018

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Post-ischaemic mild hypothermia inhibits apoptosis in the penumbral region by reducing neuronal nitric oxide synthase activity and thereby preventing endothelin-1-induced hydroxyl radical formation

21 January 2018

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Effect of resuscitative mild hypothermia on glutamate and dopamine release, apoptosis and ischaemic brain damage in the endothelin-1 rat model for focal cerebral ischaemia

21 January 2018

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Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Phosphorylation of the PTEN tail regulates protein stability and function

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Topographically graded postischemic presence of metalloproteinases is inhibited by hypothermia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Mild hypothermia prevents ischemic injury in gerbil hippocampus.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Neuroprotective effect of mild hypothermia cannot be explained in terms of a reduction of glutamate release during ischemia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Mild hypothermia ameliorates ubiquitin synthesis and prevents delayed neuronal death in the gerbil hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Mild postischemic hypothermia limits cerebral injury following transient focal ischemia in rat neocortex

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Effects of brain temperature on CBF thresholds for extracellular glutamate release and reuptake in the striatum in a rat model of graded global ischemia

21 January 2018

1 reference

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Neither L-NAME nor L-arginine changes extracellular glutamate elevation and anoxic depolarization during global ischemia and reperfusion in rat.

21 January 2018

1 reference

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Real-time monitoring of the effects of normothermia and hypothermia on extracellular glutamate re-uptake in the rat following global brain ischemia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia

21 January 2018

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Post-ischemic inflammation: molecular mechanisms and therapeutic implications

21 January 2018

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Quantitative evaluation of extracellular glutamate concentration in postischemic glutamate re-uptake, dependent on brain temperature, in the rat following severe global brain ischemia

21 January 2018

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7 January 2021

Mild hypothermic intervention after graded ischemic stress in rats

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7 January 2021

Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection.

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7 January 2021

The importance of brain temperature in alterations of the blood-brain barrier following cerebral ischemia.

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7 January 2021

Hypothermia differentially increases extracellular signal-regulated kinase and stress-activated protein kinase/c-Jun terminal kinase activation in the hippocampus during reperfusion after asphyxial cardiac arrest

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7 January 2021

The effect of extending mild hypothermia on focal cerebral ischemia and reperfusion in the rat.

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7 January 2021

Biphasic opening of the blood-brain barrier following transient focal ischemia: effects of hypothermia

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7 January 2021

Effect of selective brain hypothermia on regional cerebral blood flow and tissue metabolism using brain thermo-regulator in spontaneously hypertensive rats

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

7 January 2021

Effect of mild hypothermia on nitric oxide synthesis during focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

7 January 2021

Biphasic Expression of the Fos and Jun Families of Transcription Factors Following Transient Forebrain Ischaemia in the Rat. Effect of Hypothermia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

7 January 2021

Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

7 January 2021

Effects of adenosine agonists and an antagonist on excitatory transmitter release from the ischemic rabbit hippocampus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

7 January 2021

Mild hypothermia mitigates post-ischemic neuronal death following focal cerebral ischemia in rat brain: immunohistochemical study of Fas, caspase-3 and TUNEL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

7 January 2021

Mild hypothermia improves recovery of cortical extracellular potassium ion activity and excitability after middle cerebral artery occlusion in the rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

7 January 2021

Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

7 January 2021

Mild hypothermia reduces ICAM-1 expression, neutrophil infiltration and microglia/monocyte accumulation following experimental stroke

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600540

7 January 2021

Identifiers

DOI

10.1038/SJ.JCBFM.9600540

1 reference

3 August 2017

1 reference