(Q34661252)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Topoisomerase 1 inhibition reversibly impairs synaptic function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

6

Mark J Zylka

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

author name string

Paul H M Kullmann

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Margaret A Twomey

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Jayalakshmi Miriyala

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Benjamin D Philpot

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

language of work or name

English

0 references

publication date

17 November 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

22 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

volume

111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

issue

48

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

page(s)

17290-17295

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

22 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Transcription-generated torsional stress destabilizes nucleosomes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Genome-wide transcriptional effects of the anti-cancer agent camptothecin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Topoisomerases facilitate transcription of long genes linked to autism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Transcription poisoning by Topoisomerase I is controlled by gene length, splice sites, and miR-142-3p

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Metabolic turnover of synaptic proteins: kinetics, interdependencies and implications for synaptic maintenance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Drugging topoisomerases: lessons and challenges

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

De Novo Gene Disruptions in Children on the Autistic Spectrum

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Patterns and rates of exonic de novo mutations in autism spectrum disorders

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

What does CNTNAP2 reveal about autism spectrum disorder?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Angelman syndrome: Drugs to awaken a paternal gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

The postsynaptic organization of synapses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Phase 2 clinical trial of intrathecal topotecan in children with refractory leptomeningeal leukemia: a Children's Oncology Group trial (P9962).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Regression of recurrent malignant gliomas with convection-enhanced delivery of topotecan

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Contribution of GABAergic interneurons to the development of spontaneous activity patterns in cultured neocortical networks.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Neuroligins and neurexins link synaptic function to cognitive disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Neuroligins determine synapse maturation and function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

DNA topoisomerase I in the mouse central nervous system: Age and sex dependence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Control of excitatory and inhibitory synapse formation by neuroligins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Expression of distinct alpha subunits of GABAA receptor regulates inhibitory synaptic strength

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Postnatal Neurodevelopmental Disorders: Meeting at the Synapse?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Development of excitatory synapses in cultured neurons dissociated from the cortices of rat embryos and rat pups at birth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

DNA topoisomerase IIbeta and neural development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Molecular and functional diversity of the expanding GABA-A receptor gene family

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Binding of neuroligins to PSD-95

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Autism or atypical autism in maternally but not paternally derived proximal 15q duplication

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Neurodevelopmental disorders. New hope for a devastating neurological disorder

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1413204111

Golgi bypass: skirting around the heart of classical secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1413204111

Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1413204111

Spontaneous development of synchronous oscillatory activity during maturation of cortical networks in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1413204111

Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1413204111

Glutamate regulates the activity of topoisomerase I in mouse cerebellum

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1413204111

Seizure suppression by top1 mutations in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1413204111

DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1413204111

Early patterns of verbal memory impairment in children treated for medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1413204111

Synchronous oscillatory activity in immature cortical network is driven by GABAergic preplate neurons.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260568

Frequency of synchronous oscillations of neuronal activity increases during development and is correlated to the number of synapses in cultured cortical neuron networks

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25404338

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1413204111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

25404338

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404338%20AND%20SRC:MED&resulttype=core&format=json