(Q34669448)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Cellular localization and functional significance of CYP3A4 in the human epileptic brain (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Nicola Marchi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

author name string

Nirav K Desai

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Vikram Puvenna

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Mohammed Hossain

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Jorge Gonzalez-Martinez

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Andreas V Alexopoulos

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Damir Janigro

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

language of work or name

1 reference

5 February 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

volume

52

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

page(s)

562-571

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow

21 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Transporters in drug-refractory epilepsy: clinical significance.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Management of the patient with medically refractory epilepsy.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Cell death induced by N-methyl-N-nitrosourea, a model S(N)1 methylating agent, in two lung cancer cell lines of human origin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Drug treatment of epilepsy: options and limitations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Structural basis of human pregnane X receptor activation by the hops constituent colupulone

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

The clinical impact of pharmacogenetics on the treatment of epilepsy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

MDR- and CYP3A4-mediated drug-drug interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Human pregnane X receptor and resistance to chemotherapy in prostate cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Expression and function of cytochrome p450 in brain drug metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

The blood-brain barrier and epilepsy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Drug resistance in brain diseases and the role of drug efflux transporters.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Adverse motor effects induced by antiepileptic drugs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Significance of MDR1 and multiple drug resistance in refractory human epileptic brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Terminology and classification of the cortical dysplasias

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Antiepileptic drugs and apoptotic neurodegeneration in the developing brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Interaction of cytochrome P450 3A inhibitors with P-glycoprotein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Cytochrome P450 isozymes and antiepileptic drug interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy

7 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Mechanisms of endothelial survival under shear stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Relationship between expression of multiple drug resistance proteins and p53 tumor suppressor gene proteins in human brain astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Expression of CYP3A4 as a predictor of response to chemotherapy in peripheral T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Aromatic antiepileptic drugs and mitochondrial toxicity: effects on mitochondria isolated from rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Localization of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056924

Drug metabolizing enzymes in the brain and cerebral microvessels

26 October 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2010.02956.X

Analysis of carbamazepine and its active metabolite, carbamazepine-10,11-epoxide, in human plasma using high-performance liquid chromatography

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21294720

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The pregnane X receptor: from bench to bedside

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21294720

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Carbamazepine toxicity after starting combination antiretroviral therapy including ritonavir and efavirenz

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21294720

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1528-1167.2010.02956.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

21294720

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21294720%20AND%20SRC:MED&resulttype=core&format=json