(Q34688159)

3 August 2017

1 reference

title

Are there roles for brain cell senescence in aging and neurodegenerative disorders? (English)

1 reference

3 August 2017

1 reference

1 reference

4

Mark P Mattson

1 reference

3 August 2017

Florence C C Tan

1

1 reference

3 August 2017

Emmette R Hutchison

series ordinal

2

1 reference

3 August 2017

Erez Eitan

series ordinal

3

1 reference

3 August 2017

publication date

11 October 2014

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3 August 2017

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3 August 2017

volume

15

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3 August 2017

issue

6

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3 August 2017

page(s)

643-660

1 reference

https://scigraph.springernature.com/pub.10.1007/s10522-014-9532-1

3 August 2017

exact match

0 references

cites work

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7 July 2018

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2, 3, 7, 8-Tetrachlorodibenzo-P-dioxin (TCDD) induces premature senescence in human and rodent neuronal cells via ROS-dependent mechanisms

7 July 2018

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Tau promotes neurodegeneration through global chromatin relaxation

7 July 2018

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7 July 2018

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Amyloid-β(1-42) oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2

7 July 2018

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7 July 2018

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Alzheimer's as a metabolic disease

7 July 2018

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TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

7 July 2018

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7 July 2018

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Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

7 July 2018

1 reference

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The role of autophagy in neurodegenerative disease

7 July 2018

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

7 July 2018

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Senescence-associated lysosomal α-L-fucosidase (SA-α-Fuc): a sensitive and more robust biomarker for cellular senescence beyond SA-β-Gal

7 July 2018

1 reference

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Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson's disease

7 July 2018

1 reference

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Activation of transposable elements during aging and neuronal decline in Drosophila

7 July 2018

1 reference

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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Markers of cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Centenarians, but not octogenarians, up-regulate the expression of microRNAs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

MicroRNAs and neurodegeneration: role and impact

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Astrocyte senescence as a component of Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Role of microRNA processing in adipose tissue in stress defense and longevity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

A Micro-RNA Connection in BRaf(V600E)-Mediated Premature Senescence of Human Melanocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Lamin B1 loss is a senescence-associated biomarker.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Reduced expression of MECP2 affects cell commitment and maintenance in neurons by triggering senescence: new perspective for Rett syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspective.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

The role of nuclear lamin B1 in cell proliferation and senescence.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Autophagy impairment induces premature senescence in primary human fibroblasts.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Mitochondrial dysfunction in long-term neuronal cultures mimics changes with aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Cell cycle arrest is not senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

The essence of senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Developmental genetics of vertebrate glial-cell specification.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Cultured cerebellar granule neurons as an in vitro aging model: topoisomerase IIβ as an additional biomarker in DNA repair and aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Autophagy gone awry in neurodegenerative diseases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Systemic inflammatory cells fight off neurodegenerative disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Growth and aging: a common molecular mechanism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

The senescence-associated secretory phenotype: the dark side of tumor suppression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Astrocytes: biology and pathology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Alterations in microRNA expression in stress-induced cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Identification of subpopulations in mesenchymal stem cell-like cultures from human umbilical cord

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Autophagy mediates the mitotic senescence transition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Epigenetic changes in Alzheimer's disease: decrements in DNA methylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

The effects of aging, injury and disease on microglial function: a case for cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

The classical complement cascade mediates CNS synapse elimination

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

p38 MAP-kinases pathway regulation, function and role in human diseases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Molecular dissection of formation of senescence-associated heterochromatin foci

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Microglial senescence: does the brain's immune system have an expiration date?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Microglia in the aging brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

A developmental timing microRNA and its target regulate life span in C. elegans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Protein oxidation and degradation during postmitotic senescence.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Gene regulation and DNA damage in the ageing human brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Why do neurons enter the cell cycle?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

The serial cultivation of human diploid cell strains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Chronic stress and age-related increases in the proinflammatory cytokine IL-6

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Methylation and acetylation in nervous system development and neurodegenerative disorders

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Ageing and telomeres: a study into organ- and gender-specific telomere shortening

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Staging of brain pathology related to sporadic Parkinson's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Cellular longevity: role of apoptosis and replicative senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Phenotypic and functional changes in glial cells as a function of age.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Sphingomyelin and ceramide as regulators of development and lifespan

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Cellular senescence: mitotic clock or culture shock?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Microinjection of anti-p21 antibodies induces senescent Hs68 human fibroblasts to synthesize DNA but not to divide

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Extension of life-span by introduction of telomerase into normal human cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Role of ceramide in cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Quantitative morphological changes in neurons and glia in the frontal lobe of the aging rat.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Regulation of two E2F-related genes in presenescent and senescent human fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Age-dependent changes in calcium currents and calcium homeostasis in mammalian neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Oxidative DNA damage and senescence of human diploid fibroblast cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Increased p53 protein associated with aging in human diploid fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Telomeres shorten during ageing of human fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

IL-6-mediated events in Alzheimer's disease pathology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Altered chromatin conformation in Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons.

7 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Stress-induced senescence in human and rodent astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Effect of aging on the microglial response to peripheral nerve injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Genome-wide miRNA signatures of human longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Evidence that aging and amyloid promote microglial cell senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Expression patterns of retinoblastoma protein in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Cell cycle activation linked to neuronal cell death initiated by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Developmental stage of oligodendrocytes determines their response to activated microglia in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Programmed cell senescence during mammalian embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Astrocytes aged in vitro show a decreased neuroprotective capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Increased age is associated with epigenetic and structural changes in chromatin from neuronal nuclei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Senescence is a developmental mechanism that contributes to embryonic growth and patterning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Dystrophic microglia in the aging human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

P38 MAP kinase is activated at early stages in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

The NetAge database: a compendium of networks for longevity, age-related diseases and associated processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

The effect of sulfated hyaluronan on the morphological transformation and activity of cultured human astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Lysosomal β-galactosidase and β-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and type 2 diabetes mellitus.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

A P53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Mitochondrial abnormalities in Alzheimer's disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264619

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

26 October 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9532-1

Lack of replicative senescence in cultured rat oligodendrocyte precursor cells

21 January 2018

1 reference

12 December 2020

Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro

1 reference

12 December 2020

Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein

1 reference

12 December 2020

A study of mitochondria in spinal ganglion neurons during life: quantitative changes from youth to extremely advanced age

1 reference

12 December 2020

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

1 reference

12 December 2020

Age-induced hypertrophy of astrocytes in rat supraoptic nucleus: a cytological, morphometric, and immunocytochemical study

1 reference

12 December 2020

Decrease in the nucleo-cytoplasmic volume ratio of rabbit spinal ganglion neurons with age

1 reference

12 December 2020

Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease

1 reference

12 December 2020

Golgi study of the mouse striatum: age-related dendritic changes in different neuronal populations

1 reference

12 December 2020

Comparison of global DNA methylation profiles in replicative versus premature senescence

1 reference

12 December 2020

Lysosomal storage diseases as disorders of autophagy

1 reference

12 December 2020

Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells

1 reference

12 December 2020

Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease

1 reference

12 December 2020

1 reference

12 December 2020

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

12 December 2020

Remodeling chromatin for senescence

1 reference

12 December 2020

Effects of aging on myelinated nerve fibers in monkey primary visual cortex

1 reference

12 December 2020

10.1007/S10522-014-9532-1

Identifiers

DOI

1 reference

Dimensions Publication ID

3 August 2017

0 references

1 reference

3 August 2017

1 reference