(Q34689235)

4 August 2017

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title

Telomere length, stem cells and aging (English)

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4 August 2017

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Maria A Blasco

1

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publication date

1 October 2007

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4 August 2017

Nature Chemical Biology

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4 August 2017

3

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4 August 2017

10

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4 August 2017

640-649

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https://scigraph.springernature.com/pub.10.1038/nchembio.2007.38

4 August 2017

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Increased p53 activity does not accelerate telomere-driven ageing

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Telomerase regulation and stem cell behaviour

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Mammalian telomeres end in a large duplex loop

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T-loops and the origin of telomeres

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Homologous recombination generates T-loop-sized deletions at human telomeres

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7 January 2021

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

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PTOP interacts with POT1 and regulates its localization to telomeres

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TRF2 Protects Human Telomeres from End-to-End Fusions

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres

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Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase

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The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair

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7 January 2021

MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres

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7 January 2021

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

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7 January 2021

Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.

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Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

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Telomere maintenance requires the RAD51D recombination/repair protein

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7 January 2021

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7 January 2021

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7 January 2021

Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres

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7 January 2021

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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7 January 2021

Modification of subtelomeric DNA

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7 January 2021

Protein composition of catalytically active human telomerase from immortal cells

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The first molecular details of ALT in human tumor cells

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7 January 2021

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7 January 2021

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

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7 January 2021

Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

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7 January 2021

Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA

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7 January 2021

Impaired germinal center reaction in mice with short telomeres.

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7 January 2021

Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

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7 January 2021

Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres

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7 January 2021

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

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7 January 2021

Functional characterization and developmental regulation of mouse telomerase RNA.

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7 January 2021

Essential role of mouse telomerase in highly proliferative organs

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7 January 2021

Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

A DNA damage checkpoint response in telomere-initiated senescence

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

DNA damage foci at dysfunctional telomeres

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomerase therapeutics for cancer: challenges and new directions

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Molecular mechanism of nucleotide excision repair.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Targeted deletion reveals an essential function for the telomere length regulator Trf1.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Resolution of sister telomere association is required for progression through mitosis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Accelerated telomere shortening in response to life stress

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Obesity, cigarette smoking, and telomere length in women

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

High-throughput telomere length quantification by FISH and its application to human population studies

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

The effects of social status on biological aging as measured by white-blood-cell telomere length.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomere attrition and Chk2 activation in human heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Chromosomal instability in ulcerative colitis is related to telomere shortening

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomere shortening in atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4+ T Cell Turnover

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Association between telomere length in blood and mortality in people aged 60 years or older

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

A telomerase component is defective in the human disease dyskeratosis congenita

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Adult-onset pulmonary fibrosis caused by mutations in telomerase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomerase mutations in families with idiopathic pulmonary fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Stem cells, aging, and cancer: inevitabilities and outcomes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Effects of telomerase and telomere length on epidermal stem cell behavior

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Conditional telomerase induction causes proliferation of hair follicle stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Distinct stem cell populations regenerate the follicle and interfollicular epidermis.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Constitutive telomerase expression promotes mammary carcinomas in aging mice

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.38

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.2007.38

1 reference

release_fk2lnu52ingpfbgqsuf4xpycha

4 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fk2lnu52ingpfbgqsuf4xpycha

24 November 2022

mapped directly with Wikidata item

PubMed ID

17876321

1 reference

PubMed ID

17876321