(Q34695913)

4 August 2017

title

3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria (English)

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4 August 2017

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Matthew D Lynx

1

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4 August 2017

Edward E McKee

series ordinal

2

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4 August 2017

language of work or name

English

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publication date

25 April 2006

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4 August 2017

published in

Biochemical Pharmacology

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4 August 2017

volume

72

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4 August 2017

issue

2

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4 August 2017

page(s)

239-243

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3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity

4 August 2017

cites work

1 reference

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7 July 2018

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7 July 2018

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Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity

7 July 2018

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Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency

7 July 2018

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mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency

7 July 2018

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Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

7 July 2018

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Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation

7 July 2018

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Physiological concentrations of purines and pyrimidines

7 July 2018

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Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

7 July 2018

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7 July 2018

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Site specific alterations of adipose tissue mitochondria in 3'-azido-3'-deoxythymidine (AZT)-treated rats: an early stage in lipodystrophy?

7 July 2018

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Uridine pharmacokinetics of mitocnol, a sugar cane extract

26 October 2018

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Uridine excess does not interfere with the antiretroviral efficacy of nucleoside analogue reverse transcriptase inhibitors

26 October 2018

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Uridine abrogates mitochondrial toxicity related to nucleoside analogue reverse transcriptase inhibitors in HepG2 cells

26 October 2018

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26 October 2018

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Dilated cardiomyopathy in an adult human immunodeficiency virus type 1-positive patient treated with a zidovudine-containing antiretroviral regimen

26 October 2018

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Concentration-controlled compared with conventional antiretroviral therapy for HIV infection

26 October 2018

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Zidovudine phosphorylation and mitochondrial toxicity in vitro

26 October 2018

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Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

26 October 2018

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Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster

26 October 2018

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Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion.

26 October 2018

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Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells

26 October 2018

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Early features of zidovudine-associated myopathy: histopathological findings and clinical correlations

26 October 2018

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12 December 2020

Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine

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12 December 2020

Hepatic Morphological alterations induced by zidovudine (ZDV) in an experimental model

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12 December 2020

The bottleneck in AZT activation

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12 December 2020

Mitochondria as Cell Targets of AZT (Zidovudine)

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12 December 2020

10.1016/J.BCP.2006.04.004

Identifiers

DOI

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4 August 2017

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4 August 2017

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