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Genetic approaches to the study of Toll-like receptor function
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Genetic approaches to the study of Toll-like receptor function
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
main subject
toll-like receptor
0 references
author
Osamu Takeuchi
object named as
Osamu Takeuchi
series ordinal
1
1 reference
stated in
ORCID Public Data File 2021
author name string
Shizuo Akira
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
language of work or name
English
1 reference
based on heuristic
inferred from title
publication date
1 July 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
published in
Microbes and Infection
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
volume
4
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
issue
9
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
page(s)
887-895
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
cites work
The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
1 reference
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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
1 reference
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Crossref
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The Toll-receptor family and control of innate immunity
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7 January 2021
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The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
1 reference
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reference URL
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Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
1 reference
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reference URL
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A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans
1 reference
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reference URL
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Signaling in plant-microbe interactions
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
1 reference
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reference URL
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7 January 2021
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inferred from DOI database lookup
A family of human receptors structurally related to Drosophila Toll
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
TLR6: A novel member of an expanding toll-like receptor family
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
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Crossref
reference URL
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7 January 2021
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Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
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Crossref
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7 January 2021
based on heuristic
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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
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Crossref
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7 January 2021
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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
1 reference
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7 January 2021
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inferred from DOI database lookup
Innate immunity: the virtues of a nonclonal system of recognition
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
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inferred from DOI database lookup
Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
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Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
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Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of direct antimicrobial activity through mammalian toll-like receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Co-operative induction of pro-inflammatory signaling by Toll-like receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Discrimination of bacterial lipoproteins by Toll-like receptor 6
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human Nod1 confers responsiveness to bacterial lipopolysaccharides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The extra domain A of fibronectin activates Toll-like receptor 4.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
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A Toll-like receptor recognizes bacterial DNA
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unresponsiveness of MyD88-deficient mice to endotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptors control activation of adaptive immune responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endotoxin-induced maturation of MyD88-deficient dendritic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TIRAP: an adapter molecule in the Toll signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1286-4579(02)01615-5
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
PubMed ID
12106781
1 reference
stated in
Europe PubMed Central
PubMed ID
12106781
retrieved
4 August 2017
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