(Q34751713)

4 August 2017

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title

Ras regulation of DNA-methylation and cancer (English)

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4 August 2017

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1

Samir Kumar Patra

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PubMed ID

18282569

4 August 2017

language of work or name

English

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publication date

26 January 2008

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Experimental Cell Research

4 August 2017

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4 August 2017

314

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4 August 2017

1193-1201

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4 August 2017

6

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4 August 2017

The mammalian epigenome

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Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects

7 January 2021

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Epigenetic reprogramming in mammalian development

7 January 2021

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DNA methyltransferase and demethylase in human prostate cancer

7 January 2021

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Histone deacetylase and DNA methyltransferase in human prostate cancer

7 January 2021

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The epigenomics of cancer

7 January 2021

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Hypomethylation of ras oncogenes in primary human cancers

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Hypomethylation of DNA from benign and malignant human colon neoplasms

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Gene regulation by histone H1: new links to DNA methylation.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Reprogramming of genome function through epigenetic inheritance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

The DNA methyltransferases of mammals

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol

7 January 2021

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Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

7 January 2021

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Rho GTPases in cell biology

7 January 2021

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7 January 2021

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Characterization of interactions between ras family GTPases and their effectors

7 January 2021

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Conspiracy theory: RAS and RAF do not act alone

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

7 January 2021

1 reference

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Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models

7 January 2021

1 reference

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The synergistic activation of Raf-1 kinase by phorbol myristate acetate and hydrogen peroxide in NIH3T3 cells

7 January 2021

1 reference

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Raf-1 protein kinase is an integral component of the oncogenic signal cascade shared by epidermal growth factor and platelet-derived growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Oncogene protein co-expression. Value of Ha-ras, c-myc, c-fos, and p53 as prognostic discriminants for breast carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Differential Ras activation between caveolae/raft and non-raft microdomains

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Ras proteins: different signals from different locations

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

H-Ras dynamically interacts with recycling endosomes in CHO-K1 cells: involvement of Rab5 and Rab11 in the trafficking of H-Ras to this pericentriolar endocytic compartment.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Lipid rafts and plasma membrane microorganization: insights from Ras.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Dissecting lipid raft facilitated cell signaling pathways in cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

The Polycomb group protein EZH2 directly controls DNA methylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

The polycomb group protein EZH2 is involved in progression of prostate cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

The polycomb group protein enhancer of zeste homolog 2 (EZH 2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Activated p53 suppresses the histone methyltransferase EZH2 gene.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Functional cooperation between HP1 and DNMT1 mediates gene silencing.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Regulation of DNA methylation by the Ras signaling pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas.

7 January 2021

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Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

K-ras mutations and RASSF1A promoter methylation in colorectal cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

MGMT promoter methylation and field defect in sporadic colorectal cancer.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Local DNA demethylation in vertebrates: how could it be performed and targeted?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Ras induces a general DNA demethylation activity in mouse embryonal P19 cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Targeting the RAS signaling pathway in malignant hematologic diseases

7 January 2021

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7 January 2021

Targeting oncogenic Ras.

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Methotrexate and Ras methylation: a new trick for an old drug?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

p19ras interacts with and activates p73 by involving the MDM2 protein

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.01.012

10.1016/J.YEXCR.2008.01.012

7 January 2021

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

18282569