(Q35708595)

9 August 2017

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title

Methotrexate and Ras methylation: a new trick for an old drug? (English)

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9 August 2017

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Mark R Philips

1

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9 August 2017

language of work or name

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16 March 2004

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Science's STKE : signal transduction knowledge environment

9 August 2017

published in

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9 August 2017

volume

2004

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9 August 2017

issue

225

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9 August 2017

page(s)

pe13

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Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

9 August 2017

cites work

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https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Ras family signaling: therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Creation of human tumour cells with defined genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Essential role for oncogenic Ras in tumour maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Farnesyltransferase inhibitors: promises and realities

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Guanosine triphosphatase stimulation of oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Carboxyl methylation of Ras regulates membrane targeting and effector engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004PE13

21 January 2018

Identifiers

DOI

10.1126/STKE.2252004PE13

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9 August 2017

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