(Q34778122)

4 August 2017

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title

Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development (English)

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4 August 2017

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Joanna L Jankowsky

1

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4 August 2017

Alena Savonenko

2

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4 August 2017

Gabriele Schilling

3

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4 August 2017

Jiou Wang

4

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4 August 2017

Guilian Xu

5

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4 August 2017

David R Borchelt

6

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4 August 2017

1 September 2002

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Current Neurology and Neuroscience Reports

4 August 2017

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4 August 2017

2

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4 August 2017

5

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4 August 2017

457-464

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https://scigraph.springernature.com/pub.10.1007/s11910-002-0073-7

4 August 2017

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cites work

Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins

1 reference

12 December 2020

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

1 reference

12 December 2020

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

1 reference

12 December 2020

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

1 reference

12 December 2020

Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide

1 reference

12 December 2020

Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold

1 reference

12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

12 December 2020

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

12 December 2020

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

1 reference

12 December 2020

Genetic neurodegenerative diseases: the human illness and transgenic models

1 reference

12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

12 December 2020

Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model

1 reference

12 December 2020

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.

1 reference

12 December 2020

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

12 December 2020

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

1 reference

12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

12 December 2020

ALS, SOD and peroxynitrite

1 reference

12 December 2020

Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.

1 reference

12 December 2020

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

12 December 2020

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs

1 reference

12 December 2020

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

12 December 2020

When more is less: pathogenesis of glutamine repeat neurodegenerative diseases

1 reference

12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

12 December 2020

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

1 reference

12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 December 2020

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

1 reference

12 December 2020

Huntington disease and the related disorder, dentatorubral-pallidoluysian atrophy (DRPLA).

1 reference

12 December 2020

Peripheral prion pursuit

1 reference

12 December 2020

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

1 reference

12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

12 December 2020

Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function.

1 reference

12 December 2020

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

12 December 2020

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD.

1 reference

12 December 2020

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease

1 reference

12 December 2020

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

1 reference

12 December 2020

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

12 December 2020

Neuroinvasion of prions: insights from mouse models

1 reference

12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

12 December 2020

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

1 reference

12 December 2020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

Neuron loss in APP transgenic mice

1 reference

12 December 2020

Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase

1 reference

12 December 2020

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase

1 reference

12 December 2020

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

1 reference

12 December 2020

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

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12 December 2020

Prion Protein Biology

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12 December 2020

Lipoic acid improves survival in transgenic mouse models of Huntington's disease

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12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

12 December 2020

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

12 December 2020

Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

1 reference

12 December 2020

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

1 reference

12 December 2020

The copper chaperone for superoxide dismutase

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12 December 2020

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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12 December 2020

10.1007/S11910-002-0073-7

Identifiers

DOI

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Dimensions Publication ID

4 August 2017

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