(Q34805346)

English

The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

0 references

1 reference

based on heuristic

inferred from title

5

object named as

David D L Bowtell

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

author name string

Jaclyn Sceneay

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Mira C P Liu

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Anna Chen

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Christina S F Wong

4

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Andreas Möller

6

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

language of work or name

0 references

publication date

20 June 2013

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

e66388

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

copyright license

Creative Commons Attribution 4.0 International

20 June 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Targeting hypoxia in cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hypoxia-inducible factors and the response to hypoxic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hypoxia and hypoxia-inducible factors: master regulators of metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

N-acetylcysteine: multiple clinical applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Structural adaptation and heterogeneity of normal and tumor microvascular networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Inhibition of Siah ubiquitin ligase function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

HIF-dependent antitumorigenic effect of antioxidants in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Interventions for paracetamol (acetaminophen) overdose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

N-acetylcysteine -- passe-partout or much ado about nothing?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Regulation of angiogenesis by hypoxia: role of the HIF system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Molecular mechanisms of N-acetylcysteine actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hypoxia--a key regulatory factor in tumour growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

8 July 2018

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066388

21 January 2018

Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066388

21 January 2018

Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066388

21 January 2018

A novel orthotopic model of breast cancer metastasis to bone.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066388

21 January 2018

Immunohistochemical detection of tumour hypoxia

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066388

21 January 2018

N-acetylcysteine reduces respiratory burst but augments neutrophil phagocytosis in intensive care unit patients

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066388

21 January 2018

Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066388

21 January 2018

N-acetyl-L-cysteine does not affect the pharmacokinetics or myelosuppressive effect of busulfan during conditioning prior to allogeneic stem cell transplantation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066388

21 January 2018

Human neutrophil oxidative bursts and their in vitro modulation by different N-acetylcysteine concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

26 October 2018

Inhibition of angiogenesis-driven Kaposi's sarcoma tumor growth in nude mice by oral N-acetylcysteine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

26 October 2018

SELECT: the next prostate cancer prevention trial. Selenum and Vitamin E Cancer Prevention Trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

26 October 2018

Safety of High-Dose Vitamin A

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066388

21 January 2018

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688768

9 December 2018

Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of N-acetylcysteine on the urotoxicity produced by oxazaphosphorine without interference with anticancer activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ifosfamide plus N-acetylcysteine in the treatment of small cell and non-small cell carcinoma of the lung: a Southeastern Cancer Study Group Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine in combination with radiotherapy in the treatment of non-small cell lung cancer: a feasibility study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical development plan: N-Acetyl-l-cysteine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergism betweenN-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetyl cysteine attenuates acute lung injury in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained enhanced growth of carcinoma EO771 in C57 black mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0066388

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

2013PLoSO...866388S

0 references

release_qfaz5j32zzbqbkbysepcli4c4u

1 reference

https://api.fatcat.wiki/v0/release/qfaz5j32zzbqbkbysepcli4c4u

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34805346&oldid=1864588329"