(Q34810278)

4 August 2017

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title

Comparative analyses of immunoglobulin genes: surprises and portents (English)

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4 August 2017

1

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4 August 2017

1 September 2002

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Nature Reviews Immunology

4 August 2017

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4 August 2017

2

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4 August 2017

688-698

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4 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nri889

4 August 2017

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cites work

A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

1 reference

Kinetic and affinity limits on antibodies produced during immune responses

21 January 2018

1 reference

Eleven distinct VH gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis

21 January 2018

1 reference

Mutation, selection, and memory in B lymphocytes of exothermic vertebrates.

21 January 2018

1 reference

alpha, beta, gamma, and delta T cell antigen receptor genes arose early in vertebrate phylogeny.

21 January 2018

1 reference

The functions of the thymus system and the bursa system in the chicken

21 January 2018

1 reference

Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius

21 January 2018

1 reference

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity.

21 January 2018

1 reference

Development of B cells expressing surface immunoglobulin molecules that lack V(D)J-encoded determinants in the avian embryo bursa of fabricius

21 January 2018

1 reference

Efficient antibody diversification by gene conversion in vivo in the absence of selection for V(D)J-encoded determinants

21 January 2018

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A theory of the ontogeny of the chicken humoral immune system: the consequences of diversification by gene hyperconversion and its extension to rabbit

21 January 2018

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Immunoglobulin gene organization and the mechanism of repertoire development

21 January 2018

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Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity

21 January 2018

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Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits

21 January 2018

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Intestinal microflora and diversification of the rabbit antibody repertoire.

21 January 2018

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CD5 is a potential selecting ligand for B cell surface immunoglobulin framework region sequences

21 January 2018

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Generation of the primary antibody repertoire in rabbits: expression of a diverse set of Igk-V genes may compensate for limited combinatorial diversity at the heavy chain locus

21 January 2018

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Expanding the role of Peyer's patches in B-cell ontogeny.

21 January 2018

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Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches.

21 January 2018

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Diversification of sheep immunoglobulins.

21 January 2018

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Analysis of the diversity of a sheep antibody repertoire as revealed from a bacteriophage display library

21 January 2018

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Rearrangement/hypermutation/gene conversion: when, where and why?

21 January 2018

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Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution.

21 January 2018

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Evolution of antigen binding receptors

21 January 2018

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Ontogenic studies on the appearance of two classes of immunoglobulin-forming cells in the spleen of the Aleutian skate, Bathyraja aleutica, a cartilaginous fish

21 January 2018

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Two distinct immunoglobulin heavy chain isotypes in a primitive, cartilaginous fish, Raja erinacea

21 January 2018

1 reference

A new high molecular weight immunoglobulin class from the carcharhine shark: implications for the properties of the primordial immunoglobulin

21 January 2018

1 reference

A novel "chimeric" antibody class in cartilaginous fish: IgM may not be the primordial immunoglobulin.

21 January 2018

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Complex expression patterns of lymphocyte-specific genes during the development of cartilaginous fish implicate unique lymphoid tissues in generating an immune repertoire.

21 January 2018

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A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG.

21 January 2018

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Rearrangement of immunoglobulin genes in shark germ cells

21 January 2018

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Genomic clone for sandbar shark lambda light chain: generation of diversity in the absence of gene rearrangement

21 January 2018

1 reference

Generation of immunoglobulin light chain gene diversity in Raja erinacea is not associated with somatic rearrangement, an exception to a central paradigm of B cell immunity.

21 January 2018

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Toward a layered immune system

21 January 2018

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A novel chimeric Ig heavy chain from a teleost fish shares similarities to IgD.

21 January 2018

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Immunoglobulin D (IgD) of Atlantic cod has a unique structure.

21 January 2018

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Fish immunology: the utility of immortalized lymphoid cells--a mini review.

21 January 2018

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Mitogen-induced B-cell differentiation in Xenopus laevis

21 January 2018

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Nucleotide sequence of a cDNA encoding a third distinct Xenopus immunoglobulin heavy chain isotype.

21 January 2018

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Phylogen of immunoglobulin structure and function. 3. Immunoglobulins of the chicken

21 January 2018

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Membrane exon sequences of the three Xenopus Ig classes explain the evolutionary origin of mammalian isotypes.

21 January 2018

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Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory.

21 January 2018

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Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals

21 January 2018

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Palindromic but not G-rich sequences are targets of class switch recombination

21 January 2018

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Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity

21 January 2018

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Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

21 January 2018

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

1 reference

A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks

21 January 2018

1 reference

Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers

21 January 2018

1 reference

Chemokines and the tissue-specific migration of lymphocytes

21 January 2018

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

1 reference

Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line

21 January 2018

1 reference

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

21 January 2018

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AID is essential for immunoglobulin V gene conversion in a cultured B cell line

21 January 2018

1 reference

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

21 January 2018

1 reference

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

21 January 2018

1 reference

Somatic hypermutation: how many mechanisms diversify V region sequences?

21 January 2018

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Evolution of somatic hypermutation and gene conversion in adaptive immunity

21 January 2018

1 reference

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

21 January 2018

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Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene

21 January 2018

1 reference

Molecular evolution of the vertebrate immune system

21 January 2018

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New insights into V(D)J recombination and its role in the evolution of the immune system

21 January 2018

1 reference

Primordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases

21 January 2018

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Transposition mediated by RAG1 and RAG2 and the evolution of the adaptive immune system

21 January 2018

1 reference

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

1 reference

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations.

21 January 2018

1 reference

A cluster type organization of the loci of the immunoglobulin light chain in Atlantic cod (Gadus morhua L.) and rainbow trout (Oncorhynchus mykiss Walbaum) indicated by nucleotide sequences of cDNAs and hybridization analysis

21 January 2018

1 reference

Varied redox forms of teleost IgM: an alternative to isotypic diversity?

21 January 2018

1 reference

The Development of Primary and Secondary Lymphoid Tissues in the Nurse SharkGinglymostoma cirratum: B-Cell Zones Precede Dendritic Cell Immigration and T-Cell Zone Formation During Ontogeny of the Spleen

21 January 2018

1 reference

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment

21 January 2018

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Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity

31 March 2020

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Diversity and evolution of T-cell receptor variable region genes in mammals and birds

31 March 2020

1 reference

Clones of B lymphocytes in individual follicles of the bursa of Fabricius

31 March 2020

1 reference

Allotype suppression in the chicken. IV. Deletion of B cells and lack of suppressor cells during chronic suppression

31 March 2020

1 reference

Somatic hyperconversion diversifies the single Vh gene of the chicken with a high incidence in the D region

31 March 2020

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Emergence of committed B lymphoid progenitors in the developing chicken embryo.

31 March 2020

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Immunoglobulin gene hyperconversion ongoing in chicken splenic germinal centers.

31 March 2020

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APPENDIX OF THE RABBIT: A HOMOLOGUE OF THE BURSA IN THE CHICKEN?

31 March 2020

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The evolution and involution of Peyer's patches in fetal and postnatal sheep.

31 March 2020

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Apoptosis is associated with the extensive B cell death in the sheep ileal Peyer's patch and the chicken bursa of Fabricius: a possible role in B cell selection

31 March 2020

1 reference

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

31 March 2020

1 reference

Antibody repertoire development in fetal and newborn piglets, III. Colonization of the gastrointestinal tract selectively diversifies the preimmune repertoire in mucosal lymphoid tissues

31 March 2020

1 reference

A second class of immunoglobulin other than IgM present in the serum of a cartilaginous fish, the skate, Raja kenojei: Isolation and characterization

31 March 2020

1 reference

Duck immunoglobulins: structure, functions and molecular genetics

31 March 2020

1 reference

Is Xenopus IgX an analog of IgA?

31 March 2020

1 reference

A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria

31 March 2020

1 reference

Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation

31 March 2020

1 reference

Heavy-chain variable regions in carcharhine sharks: development of a comprehensive model for the evolution of VH domains among the gnathanstomes

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI889

1 reference

PubMed ID

12209137

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12209137