(Q34924892)

5 August 2017

title

The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension (English)

1 reference

5 August 2017

0 references

Jeffrey C Robinson

1

1 reference

5 August 2017

Brian B Graham

series ordinal

2

1 reference

5 August 2017

Tracey C Rouault

series ordinal

3

1 reference

5 August 2017

Rubin M Tuder

series ordinal

4

1 reference

5 August 2017

language of work or name

1 reference

1 December 2014

1 reference

American Journal of Respiratory Cell and Molecular Biology

5 August 2017

published in

1 reference

5 August 2017

volume

51

1 reference

5 August 2017

issue

6

1 reference

5 August 2017

page(s)

721-729

1 reference

An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease

5 August 2017

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8 July 2018

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8 July 2018

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High levels of zinc-protoporphyrin identify iron metabolic abnormalities in pulmonary arterial hypertension

8 July 2018

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8 July 2018

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8 July 2018

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Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation

8 July 2018

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Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities

8 July 2018

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HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease

8 July 2018

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8 July 2018

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Sequencing of 50 human exomes reveals adaptation to high altitude

8 July 2018

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Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension

8 July 2018

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8 July 2018

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8 July 2018

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MicroRNA-210: a unique and pleiotropic hypoxamir

8 July 2018

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The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

8 July 2018

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Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells

8 July 2018

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Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials

8 July 2018

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An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis

8 July 2018

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Control of iron homeostasis by an iron-regulated ubiquitin ligase

8 July 2018

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8 July 2018

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8 July 2018

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Pathology of pulmonary arterial hypertension

8 July 2018

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Pulmonary hypertension in patients with chronic obstructive pulmonary disease: advances in pathophysiology and management

8 July 2018

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The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291546

Iron homeostasis: recently identified proteins provide insight into novel control mechanisms

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291546

The cancer paradigm of severe pulmonary arterial hypertension

8 July 2018

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Pulmonary hypertension: an increasingly recognized complication of hereditary hemolytic anemias and HIV infection

8 July 2018

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Nutritional iron deficiency

8 July 2018

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Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

8 July 2018

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The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291546

A microRNA signature of hypoxia

8 July 2018

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The role of iron regulatory proteins in mammalian iron homeostasis and disease

8 July 2018

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Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

8 July 2018

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Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy

8 July 2018

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Cardiopulmonary complications of sickle cell disease: role of nitric oxide and hemolytic anemia

8 July 2018

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Divalent metal transporter 1.

8 July 2018

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Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis

8 July 2018

1 reference

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

8 July 2018

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Treatment of pulmonary arterial hypertension

8 July 2018

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

8 July 2018

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Balancing acts: molecular control of mammalian iron metabolism

8 July 2018

1 reference

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Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291546

Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291546

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

8 July 2018

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Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

8 July 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

8 July 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

8 July 2018

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Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension

8 July 2018

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Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

8 July 2018

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Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension

8 July 2018

1 reference

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Toxicity of iron and hydrogen peroxide: the Fenton reaction

8 July 2018

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Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension

8 July 2018

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Primary pulmonary hypertension. A national prospective study

8 July 2018

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Survival in patients with primary pulmonary hypertension. Results from a national prospective registry.

8 July 2018

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Updated Clinical Classification of Pulmonary Hypertension

8 July 2018

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Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights.

21 January 2018

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Iron deficiency is common in idiopathic pulmonary arterial hypertension.

21 January 2018

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Association of anemia and long-term survival in patients with pulmonary hypertension

21 January 2018

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Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension.

21 January 2018

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Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension.

21 January 2018

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Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

21 January 2018

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Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension.

21 January 2018

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Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells

21 January 2018

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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

21 January 2018

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Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development.

21 January 2018

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IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.

21 January 2018

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Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.

21 January 2018

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The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice

21 January 2018

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Sevoflurane preconditioning attenuates myocardial ischemia/reperfusion injury via caveolin-3-dependent cyclooxygenase-2 inhibition

21 January 2018

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Desferrioxamine elevates pulmonary vascular resistance in humans: potential for involvement of HIF-1.

21 January 2018

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Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis

26 October 2018

1 reference

12 December 2020

Effectiveness of deferiprone in transfusion-independent beta-thalassemia/HbE patients

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12 December 2020

Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension

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12 December 2020

Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension

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12 December 2020

Non-heme iron through the three domains of life

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12 December 2020

Hepcidin, a new iron regulatory peptide

1 reference

12 December 2020

Identifiers

DOI

10.1165/RCMB.2014-0021TR

1 reference

5 August 2017

1 reference

5 August 2017

1 reference