(Q34976291)

5 August 2017

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title

Alzheimer's disease: beta-Amyloid protein and tau. (English)

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5 August 2017

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Maho Morishima-Kawashima

series ordinal

1

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5 August 2017

Yasuo Ihara

series ordinal

2

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5 August 2017

publication date

1 November 2002

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Journal of Neuroscience Research

5 August 2017

published in

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5 August 2017

volume

70

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5 August 2017

issue

3

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5 August 2017

page(s)

392-401

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

5 August 2017

cites work

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

1 reference

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles

21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

21 January 2018

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Presenilin-dependent gamma-secretase activity modulates thymocyte development

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry

21 January 2018

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Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

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Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

21 January 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

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Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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The carboxyl third of tau is tightly bound to paired helical filaments.

21 January 2018

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A detergent-insoluble membrane compartment contains A beta in vivo

21 January 2018

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

21 January 2018

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)

21 January 2018

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Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation

21 January 2018

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Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation

21 January 2018

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Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

21 January 2018

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The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells†

21 January 2018

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Proline-directed and non-proline-directed phosphorylation of PHF-tau.

21 January 2018

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Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain

21 January 2018

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Susceptibility locus for Alzheimer's disease on chromosome 10.

21 January 2018

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

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One of the antigenic determinants of paired helical filaments is related to tau protein

21 January 2018

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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

21 January 2018

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Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain

21 January 2018

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Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12.

21 January 2018

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New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

21 January 2018

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

21 January 2018

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Gamma-secretase: never more enigmatic

21 January 2018

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Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.

21 January 2018

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Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

21 January 2018

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A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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A fluid connection: cholesterol and Abeta

21 January 2018

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Amyloid beta protein (Abeta) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

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Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.10355

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5 August 2017

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