(Q34979826)

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Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD).

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5 August 2017

Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). (English)

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5 August 2017

Alzheimer's disease

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12 June 2020

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12 June 2020

Stephen D Ginsberg

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12 June 2020

Melissa J. Alldred

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Melissa J Alldred

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17 July 2014

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5 August 2017

Brain Structure and Function

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12 June 2020

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12 June 2020

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12 June 2020

2983-2996

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12 June 2020

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Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice.

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Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.

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Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease

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The use of mouse models to understand and improve cognitive deficits in Down syndrome

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Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

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Gender differences in neurotrophin and glutamate receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer's disease

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Health conditions associated with aging and end of life of adults with Down syndrome

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Characterizations and validations of novel antibodies toward translational research

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A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model

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Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006

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Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease

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Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression

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Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome

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Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer's disease

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Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

1 reference

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8 July 2018

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

1 reference

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Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies

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8 July 2018

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

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8 July 2018

Terminal Continuation (TC) RNA amplification enables expression profiling using minute RNA input obtained from mouse brain

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8 July 2018

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

1 reference

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Terminal continuation (TC) RNA amplification without second strand synthesis

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Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn

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In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model.

1 reference

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Cholinotrophic molecular substrates of mild cognitive impairment in the elderly.

1 reference

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8 July 2018

Functional genomic methodologies.

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Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease

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8 July 2018

Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

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RNA amplification strategies for small sample populations

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Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage

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Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

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Signaling endosome hypothesis: A cellular mechanism for long distance communication

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Amplification of RNA transcripts using terminal continuation.

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App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

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Retrograde transport redux.

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Behavioral phenotype of individuals with Down syndrome

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8 July 2018

Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

1 reference

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Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

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8 July 2018

Segmental trisomy as a mouse model for Down syndrome

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8 July 2018

A mouse model for Down syndrome exhibits learning and behaviour deficits.

1 reference

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Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.

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8 July 2018

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

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21 January 2018

Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease.

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21 January 2018

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21 January 2018

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

1 reference

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21 January 2018

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

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21 January 2018

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21 January 2018

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial.

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21 January 2018

Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome.

1 reference

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21 January 2018

Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease.

1 reference

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21 January 2018

AMPA-selective glutamate receptor subtype immunoreactivity in the hippocampal formation of patients with Alzheimer's disease.

1 reference

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21 January 2018

Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome.

1 reference

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21 January 2018

Septal neurons containing glutamic acid decarboxylase immunoreactivity project to the hippocampal region in the rat brain.

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21 January 2018

Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice.

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21 January 2018

Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis.

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21 January 2018

Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes.

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21 January 2018

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21 January 2018

Memantine in moderate-to-severe Alzheimer's disease

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21 January 2018

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

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21 January 2018

Global disruption of the cerebellar transcriptome in a Down syndrome mouse model.

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21 January 2018

Effects of memantine on clinical ratings, fluorodeoxyglucose positron emission tomography measurements, and cerebrospinal fluid assays in patients with moderate to severe Alzheimer dementia: a 24-week, randomized, clinical trial

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21 January 2018

Selective impairment of some forms of synaptic plasticity by oligomeric amyloid-β peptide in the mouse hippocampus: implication of extrasynaptic NMDA receptors.

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26 October 2018

Impaired LTP- but not LTD-like cortical plasticity in Alzheimer's disease patients.

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26 October 2018

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26 October 2018

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

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26 October 2018

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26 October 2018

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26 October 2018

Loss of GABAergic neurons in medial septum after fimbria-fornix transection

1 reference

https://pubmed.ncbi.nlm.nih.gov/25031177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00429-014-0839-0

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25031177%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25031177%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25031177%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

ResearchGate publication ID

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