(Q34981350)

5 August 2017

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title

The use of constitutively active GPCRs in drug discovery and functional genomics (English)

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G protein-coupled receptor

5 August 2017

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G protein-coupled receptor signaling in absence of ligand

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Gene Ontology release 2020-05-02

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Derek T Chalmers

1

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5 August 2017

Dominic P Behan

series ordinal

2

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5 August 2017

language of work or name

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1 August 2002

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Nature Reviews Drug Discovery

5 August 2017

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5 August 2017

1

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5 August 2017

599-608

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5 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrd872

5 August 2017

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cites work

G-protein-coupled receptors and signaling networks: emerging paradigms.

1 reference

Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology

31 March 2020

1 reference

The Sequence of the Human Genome

31 March 2020

1 reference

Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors

31 March 2020

1 reference

Cloning and expression of a rat D2 dopamine receptor cDNA

31 March 2020

1 reference

Cloning and expression of the A2a adenosine receptor from guinea pig brain.

31 March 2020

1 reference

Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.

31 March 2020

1 reference

Identification of G protein-coupled receptor genes from the human genome sequence

31 March 2020

1 reference

Classifying G-protein coupled receptors with support vector machines

31 March 2020

1 reference

Potential histamine H2-receptor antagonists. 2. N.alpha.-Guanylhistamine

31 March 2020

1 reference

Orphan G-protein-coupled receptors: the next generation of drug targets?

31 March 2020

1 reference

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

31 March 2020

1 reference

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

31 March 2020

1 reference

A prolactin-releasing peptide in the brain

31 March 2020

1 reference

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

31 March 2020

1 reference

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

31 March 2020

1 reference

Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid

31 March 2020

1 reference

Characterization of the human cysteinyl leukotriene 2 receptor

31 March 2020

1 reference

Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

31 March 2020

1 reference

Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14).

31 March 2020

1 reference

Receptor for motilin identified in the human gastrointestinal system

31 March 2020

1 reference

Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3).

31 March 2020

1 reference

Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor

31 March 2020

1 reference

Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs

31 March 2020

1 reference

Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors

31 March 2020

1 reference

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

31 March 2020

1 reference

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

31 March 2020

1 reference

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

31 March 2020

1 reference

The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.

31 March 2020

1 reference

Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.

31 March 2020

1 reference

Phe(303) in TMVI of the alpha(1B)-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation

31 March 2020

1 reference

Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay

31 March 2020

1 reference

Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region

31 March 2020

1 reference

Crystal structure of rhodopsin: A G protein-coupled receptor

31 March 2020

1 reference

Seven-transmembrane receptors: crystals clarify

31 March 2020

1 reference

Tools for investigating functional interactions between ligands and G-protein-coupled receptors

31 March 2020

1 reference

Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted phe(335).

31 March 2020

1 reference

Mechanisms of inverse agonism at G-protein-coupled receptors

31 March 2020

1 reference

Efficacy at G-protein-coupled receptors

31 March 2020

1 reference

Inverse, protean, and ligand-selective agonism: matters of receptor conformation

31 March 2020

1 reference

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

31 March 2020

1 reference

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

31 March 2020

1 reference

High constitutive activity of native H3 receptors regulates histamine neurons in brain.

31 March 2020

1 reference

BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity

31 March 2020

1 reference

The calcium receptor and calcimimetics

31 March 2020

1 reference

Initial sequencing and analysis of the human genome

31 March 2020

1 reference

Hidden Markov models in computational biology. Applications to protein modeling

31 March 2020

1 reference

Hidden Markov models for detecting remote protein homologies

31 March 2020

1 reference

Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology

31 March 2020

1 reference

Transgenic gene knock-outs: functional genomics and therapeutic target selection

31 March 2020

1 reference

Molecular manipulation of G-protein-coupled receptors: a new avenue into drug discovery

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD872

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Dimensions Publication ID

5 August 2017

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