(Q35006421)

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Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

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Europe PubMed Central

PubMed publication ID

5 August 2017

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

fluorescein 5-isothiocyanate

1 reference

ChEBI release 2020-05-28

1 reference

based on heuristic

inferred from title

Alessandro Simi

object named as

A Simi

4

0 references

object named as

S Vella

5

0 references

object named as

A Pagano

6

0 references

Alessandro Corsaro

object named as

A Corsaro

2

0 references

Stefano Thellung

object named as

S Thellung

1

0 references

author name string

V Villa

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

T Florio

7

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

31 March 2011

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Cell Death and Disease

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

e138

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

The interaction of humic substances with the human prion protein fragment 90-231 affects its protease K resistance and cell internalization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Generating a prion with bacterially expressed recombinant prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Amyloid deposits: protection against toxic protein species?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Characterization of truncated forms of abnormal prion protein in Creutzfeldt-Jakob disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Characterization of the proapoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Cathepsin-regulated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Synthetic mammalian prions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Molecular pathways to neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Prion diseases: what is the neurotoxic molecule?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Cultured cell sublines highly susceptible to prion infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Evidence for synthesis of scrapie prion proteins in the endocytic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

8 July 2018

Extracellular protein deposition correlates with glial activation and oxidative stress in Creutzfeldt-Jakob and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.21

21 January 2018

Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein.

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.21

21 January 2018

Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231.

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.21

21 January 2018

The abnormal isoform of the prion protein accumulates in late-endosome-like organelles in scrapie-infected mouse brain

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.21

21 January 2018

Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.21

21 January 2018

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.21

21 January 2018

Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.21

21 January 2018

Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101817

26 October 2018

Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/CDDIS.2011.21

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

0 references

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