(Q46041493)

English

Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231.

scientific article published on 26 February 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231. (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

prion protein family

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Alessandro Corsaro

1

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

6

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

object named as

Claudio Russo

8

0 references

Stefano Thellung

object named as

Stefano Thellung

2

0 references

object named as

Tullio Florio

10

0 references

Alessandro Simi

object named as

Alessandro Simi

5

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author name string

Katia Chiovitti

3

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

Valentina Villa

4

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

Domenico Paludi

7

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

Antonio Aceto

9

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

publication date

26 February 2009

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

Neurotoxicity Research

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

15

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

2

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

138-154

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

https://scigraph.springernature.com/pub.10.1007/s12640-009-9015-3

0 references

Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9015-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9015-3

21 January 2018

Prion diseases of humans and animals: their causes and molecular basis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The efficacy of tetracyclines in peripheral and intracerebral prion infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic activation of ERK and neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of drugs for treatment of prion infections of the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The promise of minocycline in neurology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of two conserved glycine residues to fibrillogenesis of the 106-126 prion protein fragment. Evidence that a soluble variant of the 106-126 peptide is neurotoxic

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does tetracycline bind helix 2 of prion? An integrated spectroscopical and computational study of the interaction between the antibiotic and α helix 2 human prion protein fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic approaches for prion disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human prion diseases and bovine spongiform encephalopathy (BSE).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shattuck lecture--neurodegenerative diseases and prions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to scrapie in PrP ARR/ARQ heterozygous sheep is not caused by preferential allelic use

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modelling neurodegeneration in prion disease - applications for drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A systematic review of prion therapeutics in experimental models

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo neurotoxicity of prion protein oligomers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Squalestatin cures prion-infected neurons and protects against prion neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline as a neuroprotective agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Approaches to therapy of prion diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance of cell lines to prion toxicity aided by phospho-ERK expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The differential time-course of extracellular-regulated kinase activity correlates with the macrophage response toward proliferation or activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106-126.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetracyclines affect prion infectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion protein fragment PrP-(106-126) induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the proapoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion diseases of humans and farm animals: epidemiology, genetics, and pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation and survival influences of growth factors in human neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging pharmacotherapies for Creutzfeldt-Jakob disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Results of quinacrine administration to patients with Creutzfeldt-Jakob disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights into prion strains and neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12640-009-9015-3

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384577

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