(Q35013977)

5 August 2017

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title

Dual-specificity phosphatases as targets for antineoplastic agents (English)

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5 August 2017

4

John S Lazo

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5 August 2017

3

Peter Wipf

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5 August 2017

2

Alexander P Ducruet

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5 August 2017

Michael A Lyon

1

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5 August 2017

publication date

1 December 2002

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Nature Reviews Drug Discovery

5 August 2017

published in

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5 August 2017

volume

1

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5 August 2017

issue

12

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5 August 2017

page(s)

961-976

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https://scigraph.springernature.com/pub.10.1038/nrd963

5 August 2017

exact match

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cites work

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Crystal structure of the dual specificity protein phosphatase VHR

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Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway

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cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.

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The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

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Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

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cdc25+ functions as an inducer in the mitotic control of fission yeast.

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Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

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Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

21 January 2018

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Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2

21 January 2018

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Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C

21 January 2018

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Multiple splicing variants of cdc25B regulate G2/M progression

21 January 2018

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Kinetic analysis of the catalytic domain of human cdc25B.

21 January 2018

1 reference

Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A

21 January 2018

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Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25

21 January 2018

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Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle

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The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase

21 January 2018

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Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A

21 January 2018

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The C-terminal tail of the dual-specificity Cdc25B phosphatase mediates modular substrate recognition

21 January 2018

1 reference

Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation

21 January 2018

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Proteasome-dependent degradation of human CDC25B phosphatase

21 January 2018

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

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Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation.

21 January 2018

1 reference

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

21 January 2018

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Cdc25B activity is regulated by 14-3-3.

21 January 2018

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Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.

21 January 2018

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Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase

21 January 2018

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Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

21 January 2018

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Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

21 January 2018

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

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14-3-3 proteins associate with cdc25 phosphatases

21 January 2018

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Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation

21 January 2018

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cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2

21 January 2018

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Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase

21 January 2018

1 reference

Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15

21 January 2018

1 reference

Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease

21 January 2018

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A long twentieth century of the cell cycle and beyond

21 January 2018

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Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast

21 January 2018

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

1 reference

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

21 January 2018

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

1 reference

21 January 2018

The Hallmarks of Cancer

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CDC25 phosphatases as potential human oncogenes

21 January 2018

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Role of the Cdc25A phosphatase in human breast cancer

21 January 2018

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Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas.

21 January 2018

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Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases

21 January 2018

1 reference

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

21 January 2018

1 reference

Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures

21 January 2018

1 reference

The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1

21 January 2018

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Cdc25B functions as a novel coactivator for the steroid receptors

21 January 2018

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Cdc25 as a potential target of anticancer agents.

21 January 2018

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Menadione: spectrum of anticancer activity and effects on nucleotide metabolism in human neoplastic cell lines

21 January 2018

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Coscinosulfate, a CDC25 phosphatase inhibitor from the sponge Coscinoderma mathewsi

21 January 2018

1 reference

Growth inhibition of hepatoma cells induced by vitamin K and its analogs.

21 January 2018

1 reference

Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition

21 January 2018

1 reference

Stereoselective synthesis of the core structure of the protein phosphatase inhibitor dysidiolide

21 January 2018

1 reference

Total Synthesis of Dysidiolide

21 January 2018

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Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors

21 January 2018

1 reference

Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase

21 January 2018

1 reference

Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase

21 January 2018

1 reference

Combinatorial synthesis and biological evaluation of library of small-molecule Ser/Thr-protein phosphatase inhibitors

21 January 2018

1 reference

A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation

21 January 2018

1 reference

Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor

21 January 2018

1 reference

Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array

21 January 2018

1 reference

Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases

21 January 2018

1 reference

Generation of an Ugi library of phosphate mimic-containing compounds and identification of novel dual specific phosphatase inhibitors

21 January 2018

1 reference

The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity

21 January 2018

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Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

21 January 2018

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Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors

21 January 2018

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Dual-specific Cdc25B phosphatase: in search of the catalytic acid

21 January 2018

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Regulation of CDC25B phosphatases subcellular localization

31 March 2020

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Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition

31 March 2020

1 reference

Elevated expression of the cdc25A protein phosphatase in colon cancer

31 March 2020

1 reference

cdc25a and the splicing variant cdc25b2, but not cdc25B1, -B3 or -C, are over-expressed in aggressive human non-Hodgkin's lymphomas

31 March 2020

1 reference

Expression of the cdc25B mRNA correlated with that of N-myc in neuroblastoma

31 March 2020

1 reference

Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells

31 March 2020

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Growth inhibition and protein tyrosine phosphorylation in MCF 7 breast cancer cells by a novel K vitamin

31 March 2020

1 reference

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy,isolation, and characterization.

31 March 2020

1 reference

Dnacins, new antibiotics. I. Producing organism, fermentation, and antimicrobial activities.

31 March 2020

1 reference

Dnacin A1 and dnacin B1 are antitumor antibiotics that inhibit cdc25B phosphatase activity

31 March 2020

1 reference

Dysidiolide: A Novel Protein Phosphatase Inhibitor from the Caribbean SpongeDysidea etheriade Laubenfels

31 March 2020

1 reference

Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25

31 March 2020

1 reference

Synthesis of the novel analogues of dysidiolide and their structure-activity relationship

31 March 2020

1 reference

RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase

31 March 2020

1 reference

Stevastelins, a novel group of immunosuppressants, inhibit dual-specificity protein phosphatases

31 March 2020

1 reference

Structural determination of stevastelins, novel depsipeptides from Penicillium sp

31 March 2020

1 reference

Sulfircin: a new sesterterpene sulfate from a deep-water sponge of the genus Ircinia

31 March 2020

1 reference

New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248: taxonomy, fermentation, isolation, structural elucidation and biological properties.

31 March 2020

1 reference

Construction of a human genomic library of clones containing poly(dG-dA).poly(dT-dC) tracts by Mg(2+)-dependent triplex affinity capture. DNA polymorphism associated with the tracts

31 March 2020

1 reference

Naphthoquinone analogs as inactivators of cdc25 phosphatase

31 March 2020

1 reference

Alkyl and alkoxyethyl antineoplastic phospholipids

31 March 2020

1 reference

Novel total synthesis of the anticancer natural product dysidiolide

31 March 2020

1 reference

Enantioselective formal total synthesis of (-)-dysidiolide

31 March 2020

1 reference

A formal total synthesis of the sesterterpenoid (+/-)-dysidiolide and approaches to the syntheses of (+/-)-6-epi-, (+/-)-15-epi-, and (+/-)-6,15-bisepidysidiolide

31 March 2020

1 reference

Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel

31 March 2020

1 reference

Synthesis and antitumor activity of some new substituted quinolin-4-one and 1,7-naphthyridin-4-one analogs

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD963

1 reference

5 August 2017

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