(Q35017493)

5 August 2017

title

NURR1 in Parkinson disease--from pathogenesis to therapeutic potential (English)

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5 August 2017

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3

Anders Björklund

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author name string

Mickael Decressac

series ordinal

1

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5 August 2017

Nikolaos Volakakis

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2

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5 August 2017

Thomas Perlmann

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4

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5 August 2017

language of work or name

English

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publication date

15 October 2013

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5 August 2017

published in

Nature Reviews Neurology

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5 August 2017

volume

9

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5 August 2017

issue

11

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5 August 2017

page(s)

629-636

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2013.209

5 August 2017

exact match

0 references

1 reference

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Clinical progression in Parkinson disease and the neurobiology of axons.

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The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway

21 January 2018

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A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1

21 January 2018

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How to make a mesodiencephalic dopaminergic neuron

21 January 2018

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Dopamine neuron agenesis in Nurr1-deficient mice

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Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo

21 January 2018

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Decreased level of Nurr1 in heterozygous young adult mice leads to exacerbated acute and long-term toxicity after repeated methamphetamine exposure

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Age-dependent dopaminergic dysfunction in Nurr1 knockout mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

A common NURR1 polymorphism associated with Parkinson disease and diffuse Lewy body disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Genetic analysis of NR4A2 gene in a large population of Han Chinese patients with Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Mutations in NR4A2 associated with familial Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Characterisation of a novel NR4A2 mutation in Parkinson's disease brain

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Translated mutation in the Nurr1 gene as a cause for Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Nurr1 in Parkinson's disease and related disorders

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Ageing and Parkinson's disease: substantia nigra regional selectivity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Decreased NURR1 gene expression in patients with Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

VIP is a transcriptional target of Nurr1 in dopaminergic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

p57(Kip2) cooperates with Nurr1 in developing dopamine cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

The role of excitotoxicity in neurodegenerative disease: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Oxidative stress and neurodegeneration: where are we now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Identification of activity-dependent gene expression profiles reveals specific subsets of genes induced by different routes of Ca(2+) entry in cultured rat cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Nurr1 protein is required for N-methyl-D-aspartic acid (NMDA) receptor-mediated neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of mouse neural stem cells to neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Microarray analyses support a role for Nurr1 in resistance to oxidative stress and neuronal differentiation in neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Generation of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant nurr1 mutant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Absolute requirement of GDNF for adult catecholaminergic neuron survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Glial cell line-derived neurotrophic factor protects dopaminergic neurons from 6-hydroxydopamine toxicity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Dopaminergic neurons protected from degeneration by GDNF gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Functional recovery in parkinsonian monkeys treated with GDNF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Pathogenic lysosomal depletion in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Subcellular localisation of recombinant alpha- and gamma-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Gene expression profiling in human neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Identification of a potent agonist of the orphan nuclear receptor Nurr1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Identification of a series of highly potent activators of the Nurr1 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Discovery of ligands for Nurr1 by combined use of NMR screening with different isotopic and spin-labeling strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Anti-parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Selective allosteric ligand activation of the retinoid X receptor heterodimers of NGFI-B and Nurr1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Genetic analysis of Nurr1 haplotypes in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Pharyngeal-brachial palsy after cytomegalovirus colitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

The role of inflammation in sporadic and familial Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4-phenylpyridinium.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

α-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2013.209

[Association of the polymorphisms in NURR1 gene with Parkinson's disease]

31 March 2020

1 reference

12 December 2020

Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury

1 reference

12 December 2020

Sequential steps underlying neuronal plasticity induced by a transient exposure to gabazine

1 reference

12 December 2020

Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain.

1 reference

12 December 2020

Subcellular localization of alpha-synuclein in primary neuronal cultures: effect of missense mutations.

1 reference

12 December 2020

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

1 reference

12 December 2020

10.1038/NRNEUROL.2013.209

Identifiers

DOI

1 reference

5 August 2017

1 reference