(Q35030359)

5 August 2017

title

InAKTivation of insulin/IGF-1 signaling by dephosphorylation (English)

1 reference

5 August 2017

3

Heidi A Tissenbaum

1 reference

5 August 2017

Sri Devi Narasimhan

1

1 reference

5 August 2017

Arnab Mukhopadhyay

series ordinal

2

1 reference

5 August 2017

publication date

1 December 2009

1 reference

5 August 2017

number of pages

7

1 reference

inferred from page(s)

published in

Cell Cycle

1 reference

5 August 2017

volume

8

1 reference

5 August 2017

issue

23

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5 August 2017

page(s)

3878-3884

1 reference

Targeting protein serine/threonine phosphatases for drug development

5 August 2017

cites work

1 reference

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From promiscuity to precision: protein phosphatases get a makeover

8 July 2018

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A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation

8 July 2018

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

8 July 2018

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Genetic modelling of the PTEN/AKT pathway in cancer research

8 July 2018

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RNAi screening for kinases and phosphatases identifies FoxO regulators

8 July 2018

1 reference

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The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans

8 July 2018

1 reference

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Protein phosphatase 2A regulatory subunits and cancer.

8 July 2018

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FoxO transcription factors in the maintenance of cellular homeostasis during aging

8 July 2018

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Protein tyrosine phosphatases: functional inferences from mouse models and human diseases.

8 July 2018

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PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

8 July 2018

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Phosphatases at the heart of FoxO metabolic control

8 July 2018

1 reference

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FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases

8 July 2018

1 reference

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Genetics of aging in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

8 July 2018

1 reference

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Emerging roles of nuclear protein phosphatases

8 July 2018

1 reference

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The trifecta of aging in Caenorhabditis elegans

8 July 2018

1 reference

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Worming pathways to and from DAF-16/FOXO.

8 July 2018

1 reference

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Akt signaling and cancer: surviving but not moving on.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

The plasticity of aging: insights from long-lived mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Advances in protein kinase B signalling: AKTion on multiple fronts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Physiological functions of protein kinase B/Akt

8 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

8 July 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

PP2A fulfills its promises as tumor suppressor: which subunits are important?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Proteomic characterization of protein phosphatase complexes of the mammalian nucleus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

PKB binding proteins. Getting in on the Akt.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Protein phosphatase 2A: variety of forms and diversity of functions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Protein phosphatase 2A: the Trojan Horse of cellular signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

The structure and mechanism of protein phosphatases: insights into catalysis and regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Molecular mechanisms of the protein serine/threonine phosphatases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

More on target with protein phosphorylation: conferring specificity by location

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Regulation of protein phosphatase 1 and 2A activities by insulin during myogenesis in rat skeletal muscle cells in culture.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Genes that regulate both development and longevity in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Role of PP2A in intracellular signal transduction pathways

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109867

Protein phosphatase 2A: who shall regulate the regulator?

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19901535

12 December 2020

inferred from PubMed ID database lookup

The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19901535

12 December 2020

inferred from PubMed ID database lookup

The role of PI 3-kinase in insulin action

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19901535

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.4161/CC.8.23.10072

1 reference

5 August 2017

1 reference

5 August 2017

1 reference