(Q35031640)

5 August 2017

1 reference

title

Implications of amyloid precursor protein and subsequent beta-amyloid production to the pharmacotherapy of Alzheimer's disease (English)

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5 August 2017

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Carlos H Rojas-Fernandez

series ordinal

1

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5 August 2017

Ming Chen

series ordinal

2

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5 August 2017

Hugo L Fernandez

series ordinal

3

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5 August 2017

language of work or name

English

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publication date

1 December 2002

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5 August 2017

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5 August 2017

22

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5 August 2017

12

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5 August 2017

1547-1563

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The prevalence of dementia: a quantitative integration of the literature

5 August 2017

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

A reevaluation of the duration of survival after the onset of dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Life span and synapses: will there be a primary senile dementia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by beta protein immunostaining.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Translating cell biology into therapeutic advances in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Alzheimer's disease: a re-examination of the amyloid hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

What the evolution of the amyloid protein precursor supergene family tells us about its function

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

The beta-amyloid precursor protein and its derivatives: from biology to learning and memory processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Cellular mechanisms of beta-amyloid production and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Secretases as therapeutic targets for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

In search of gamma-secretase: presenilin at the cutting edge

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Progress toward valid transgenic mouse models for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Nerve inflammation halts trial for Alzheimer's drug.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

The presenilins in Alzheimer's disease--proteolysis holds the key.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Nuclear access and action of notch in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Two-way cleavage of β-amyloid protein precursor by multicatalytic proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Statins and the risk of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Serum lipoprotein levels, statin use, and cognitive function in older women

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Cholesterol and Alzheimer's disease: is there a link?

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Nicotinic acetylcholine involvement in cognitive function in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Nicotinic receptor abnormalities in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

The galvanization of beta-amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

An inflammatory drug prospect

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

A very incomplete comprehensive theory of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Participation in cognitively stimulating activities and risk of incident Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Physical activity and risk of cognitive impairment and dementia in elderly persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

Contribution of the proteasome to the alpha-secretase pathway in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.22.17.1547.34116

10.1592/PHCO.22.17.1547.34116

21 January 2018

Identifiers

DOI

1 reference

5 August 2017

1 reference