(Q35035840)

5 August 2017

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title

The enzymatic inactivation of the fatty acid amide class of signaling lipids (English)

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5 August 2017

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1

Benjamin F Cravatt

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5 August 2017

Aron H Lichtman

2

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5 August 2017

1 December 2002

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Chemistry and Physics of Lipids

5 August 2017

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5 August 2017

121

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5 August 2017

135-148

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5 August 2017

1-2

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(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Function of directly repeated half-sites as response elements for steroid hormone receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Characterization of the hypnotic properties of oleamide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Functional role of high-affinity anandamide transport, as revealed by selective inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Cerebrodiene, arachidonyl-ethanolamide, and hybrid structures: potential for interaction with brain cannabinoid receptors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Control of pain initiation by endogenous cannabinoids.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Candidate genes and single nucleotide polymorphisms (SNPs) in the study of human disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Chemical characterization of a family of brain lipids that induce sleep

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

The fatty acid amide hydrolase (FAAH)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Brain monoglyceride lipase participating in endocannabinoid inactivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Molecular characterization of human and mouse fatty acid amide hydrolases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Anandamide amidohydrolase of porcine brain: cDNA cloning, functional expression and site-directed mutagenesis(1).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Anticonvulsants in neuropathic pain: rationale and clinical evidence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Cerebrodiene: a brain lipid isolated from sleep-deprived cats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Down-regulation of anandamide hydrolase in mouse uterus by sex hormones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Endocannabinoids, hormone-cytokine networks and human fertility

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma ‘anandamide amidohydrolase’

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Anandamide may mediate sleep induction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Catabolism of N-acylethanolamine phospholipids by dog brain preparations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Proteins regulating the biosynthesis and inactivation of neuromodulatory fatty acid amides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

The endocannabinoid system as a target for therapeutic drugs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Cannabinoids, endogenous ligands and synthetic analogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Characterization of the 5'-sequence of the mouse fatty acid amide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Estrogen receptor mediated inhibition of cancer cell invasion and motility: an overview.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

An anorexic lipid mediator regulated by feeding.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Monoamine oxidase: from genes to behavior

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

A missense mutation in human fatty acid amide hydrolase associated with problem drug use.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Transcriptional regulation of the mouse fatty acid amide hydrolase gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Endocannabinoid signaling in the brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

Pathobiology of neuropathic pain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-3084%2802%2900147-0

10.1016/S0009-3084(02)00147-0

7 January 2021

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12505696