(Q35038663)

5 August 2017

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title

Contributions of mitochondrial alterations, resulting from bad genes and a hostile environment, to the pathogenesis of Alzheimer's disease (English)

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5 August 2017

Mark P Mattson

1

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5 August 2017

1 January 2002

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International Review of Neurobiology

5 August 2017

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5 August 2017

53

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5 August 2017

387-409

1 reference

Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Effects of complex experience on somatic growth and organ development in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

The mitochondrial spiral. An adequate cause of dementia in the Alzheimer's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Pro-apoptotic action of PAR-4 involves inhibition of NF-kappaB activity and suppression of BCL-2 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

The frequency of point mutations in mitochondrial DNA is elevated in the Alzheimer's brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Point mutations of the mtDNA control region in normal and neurodegenerative human brains

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Folate and carcinogenesis: an integrated scheme

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Stroke risk factors and stroke prevention

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Catecholamines potentiate amyloid beta-peptide neurotoxicity: involvement of oxidative stress, mitochondrial dysfunction, and perturbed calcium homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

In vivo 2-deoxyglucose administration preserves glucose and glutamate transport and mitochondrial function in cortical synaptic terminals after exposure to amyloid beta-peptide and iron: evidence for a stress response

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Functional outcome in rats transferred to an enriched environment 15 days after focal brain ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

More hippocampal neurons in adult mice living in an enriched environment

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Brain Cytochrome Oxidase in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Learning-dependent synaptic modifications in the cerebellar cortex of the adult rat persist for at least four weeks.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Environmental enrichment and cortical injury: behavioral and anatomical consequences of frontal cortex lesions.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

4-Hydroxyhexenal is a potent inducer of the mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Elevated plasma levels of homocysteine in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Exercise and risk of stroke in male physicians.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Oxidative processes in Alzheimer's disease: the role of abeta-metal interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Secreted forms of beta-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Apoptosis in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

NF-kappaB in neuronal plasticity and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Two point mutations in mitochondrial DNA of cytochrome c oxidase coexist with normal mtDNA in a patient with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Homocysteine and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Decreased synaptic density in aged brains and its prevention by rearing under enriched environment as revealed by synaptophysin contents

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Modulation byDLST of the genetic risk of Alzheimer's disease in a very elderly population

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Widespread peroxynitrite-mediated damage in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Postoperative environmental enrichment attenuates fimbria-fornix lesion-induced impairments in Morris maze performance.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Molecular regulation of neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953014-2

7 January 2021

Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

1 reference

12 January 2024

https://opencitations.net/index/api/v1/citations/10.1073/PNAS.94.9.4526

Identifiers

DOI

10.1016/S0074-7742(02)53014-2

1 reference

5 August 2017

1 reference

PubMed ID

12512347