(Q35043416)

6 August 2017

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title

Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes? (English)

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6 August 2017

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Giorgio Sesti

1

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6 August 2017

language of work or name

English

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publication date

1 January 2002

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6 August 2017

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6 August 2017

volume

34

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6 August 2017

issue

6

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6 August 2017

page(s)

444-450

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Diabetes. Causes of insulin resistance.

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

21 January 2018

1 reference

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Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

beta-Cell death during progression to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Accelerated loss of islet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Insights into insulin resistance and type 2 diabetes from knockout mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways

21 January 2018

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Insulin-stimulated insulin secretion in single pancreatic beta cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Structure of the human insulin receptor gene and characterization of its promoter

21 January 2018

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https://api.crossref.org/works/10.1080%2F078538902321012397

Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms

21 January 2018

1 reference

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Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

21 January 2018

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Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

21 January 2018

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Insulin receptor substrate 1-induced inhibition of endoplasmic reticulum Ca2+ uptake in beta-cells. Autocrine regulation of intracellular ca2+ homeostasis and insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

1 reference

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

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Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

21 January 2018

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Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.

21 January 2018

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https://api.crossref.org/works/10.1080%2F078538902321012397

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

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https://api.crossref.org/works/10.1080%2F078538902321012397

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Cellular distribution and ontogeny of insulin-like growth factors (IGFs) and IGF binding protein messenger RNAs and peptides in developing rat pancreas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Apoptosis in the pancreatic islet cells of the neonatal rat is associated with a reduced expression of insulin-like growth factor II that may act as a survival factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Fetal insulin-like growth factor-2 production is impaired in the GK rat model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development.

21 January 2018

1 reference

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Phenotypic alterations in insulin-deficient mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

Pyridine Nucleotides in Pancreatic Islets During Inhibition of Insulin Release by Exogenous Insulin12

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

UKPDS 19: Heterogeneity in NIDDM: separate contributions of IRS-1 and b3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F078538902321012397

10.1080/078538902321012397

21 January 2018

Identifiers

DOI

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6 August 2017

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