(Q35043880)

6 August 2017

title

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation (English)

1 reference

6 August 2017

main subject

transmembrane protein

0 references

author name string

Erin E Matthews

1

1 reference

6 August 2017

Damien Thévenin

2

1 reference

6 August 2017

Julia M Rogers

3

1 reference

6 August 2017

Lisa Gotow

4

1 reference

6 August 2017

Paul D Lira

5

1 reference

6 August 2017

Lawrence A Reiter

6

1 reference

6 August 2017

William H Brissette

7

1 reference

6 August 2017

Donald M Engelman

8

1 reference

6 August 2017

language of work or name

English

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publication date

14 March 2011

1 reference

6 August 2017

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6 August 2017

volume

25

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6 August 2017

issue

7

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6 August 2017

page(s)

2234-2244

1 reference

describes a project that uses

6 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3114528/fullTextXML

inferred from PubMed Central ID database lookup

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F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents

8 July 2018

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The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis

8 July 2018

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Novel thrombopoietic agents: a review of their use in idiopathic thrombocytopenic purpura

8 July 2018

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Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists

8 July 2018

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Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor

8 July 2018

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8 July 2018

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8 July 2018

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A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis

8 July 2018

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Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains

8 July 2018

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An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor.

8 July 2018

1 reference

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Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

8 July 2018

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Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.

8 July 2018

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Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer

8 July 2018

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The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper

8 July 2018

1 reference

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Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics

8 July 2018

1 reference

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Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.

8 July 2018

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Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis

8 July 2018

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Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis

8 July 2018

1 reference

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The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif

8 July 2018

1 reference

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Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

TOXCAT: a measure of transmembrane helix association in a biological membrane

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

8 July 2018

1 reference

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Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain

8 July 2018

1 reference

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Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

The identification of orally bioavailable thrombopoietin agonists.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

Ligand-independent homo- and heterodimerization of human prolactin receptor variants: inhibitory action of the short forms by heterodimerization.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

New benzimidazoles as thrombopoietin receptor agonists

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

Regulation of megakaryocytopoiesis and platelet production: lessons from animal models.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114528

New thrombopoietic growth factors

25 October 2018

1 reference

12 December 2020

Interhelical hydrogen bonding drives strong interactions in membrane proteins

1 reference

12 December 2020

Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban

1 reference

12 December 2020

Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer

1 reference

12 December 2020

Modelling Atypical Small-Molecule Mimics of an Important Stem Cell Cytokine, Thrombopoietin

1 reference

12 December 2020

Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets

1 reference

12 December 2020

Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain

1 reference

12 December 2020

Identifiers

DOI

10.1096/FJ.10-178673

1 reference

6 August 2017

1 reference

6 August 2017

1 reference