(Q35044156)

6 August 2017

title

Engineered antibody variable and constant domains as therapeutic candidates (English)

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6 August 2017

Rui Gong

1

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6 August 2017

Gengfu Xiao

series ordinal

2

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6 August 2017

publication date

1 September 2013

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Pharmaceutical patent analyst

6 August 2017

published in

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6 August 2017

volume

2

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6 August 2017

issue

5

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6 August 2017

page(s)

637-646

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Engineered CH2 domains (nanoantibodies).

6 August 2017

cites work

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Engineered antibody fragments and the rise of single domains

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Single-domain antibodies as building blocks for novel therapeutics

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Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea

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The specific variable domain of camel heavy-chain antibodies is encoded in the germline

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Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor

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Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points

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Folding mechanism of the CH2 antibody domain.

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Engineered human antibody constant domains with increased stability

21 January 2018

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Structure of an isolated unglycosylated antibody CH2 domain

21 January 2018

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Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling

21 January 2018

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N-terminal truncation of an isolated human IgG1 CH2 domain significantly increases its stability and aggregation resistance

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Shortened engineered human antibody CH2 domains: increased stability and binding to the human neonatal Fc receptor

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Pharmacokinetics of engineered human monomeric and dimeric CH2 domains

21 January 2018

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21 January 2018

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Bispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn

21 January 2018

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Soluble monomeric IgG1 Fc.

21 January 2018

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Therapeutic antibody fragments with prolonged in vivo half-lives

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Biophysical Properties of Camelid VHHDomains Compared to Those of Human VH3 Domains†

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/PPA.13.44

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6 August 2017

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