(Q35056779)

https://doi.org/10.1172/JCI169986

6 August 2017

1 reference

29 December 2023

title

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis (English)

1 reference

6 August 2017

0 references

0 references

1 reference

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

12

Augustine M K Choi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

10

Stefan W Ryter

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

11

Kiichi Nakahira

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Jong-Seok Moon

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Seonmin Lee

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Mi-Ae Park

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Ilias I Siempos

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Maria Haslip

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Patty J Lee

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Chun K Kim

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Judie Howrylak

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

language of work or name

English

0 references

publication date

9 January 2015

1 reference

Journal of Clinical Investigation

6 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

125

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

665-680

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

13 June 2020

cites work

1 reference

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8 July 2018

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Metabolomic derangements are associated with mortality in critically ill adult patients

8 July 2018

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8 July 2018

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Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation.

8 July 2018

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UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.

8 July 2018

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8 July 2018

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MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2.

8 July 2018

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8 July 2018

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An integrated clinico-metabolomic model improves prediction of death in sepsis

8 July 2018

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8 July 2018

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Inflammasomes and their roles in health and disease

8 July 2018

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8 July 2018

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Mechanisms of triglyceride accumulation in activated macrophages

8 July 2018

1 reference

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Inflammasome-regulated cytokines are critical mediators of acute lung injury

8 July 2018

1 reference

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UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.

8 July 2018

1 reference

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Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin

8 July 2018

1 reference

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Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

8 July 2018

1 reference

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

8 July 2018

1 reference

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Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis

8 July 2018

1 reference

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

8 July 2018

1 reference

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Molecular mechanism of NLRP3 inflammasome activation

8 July 2018

1 reference

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Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes

8 July 2018

1 reference

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8 July 2018

1 reference

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NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

8 July 2018

1 reference

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

8 July 2018

1 reference

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Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis

8 July 2018

1 reference

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De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

8 July 2018

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8 July 2018

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8 July 2018

1 reference

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Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels

8 July 2018

1 reference

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Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography.

8 July 2018

1 reference

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The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation

8 July 2018

1 reference

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Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice

8 July 2018

1 reference

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

8 July 2018

1 reference

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

8 July 2018

1 reference

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

8 July 2018

1 reference

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Intensive insulin therapy in the medical ICU.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

ATP citrate lyase inhibition can suppress tumor cell growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

8 July 2018

1 reference

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Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host

8 July 2018

1 reference

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The biology of mitochondrial uncoupling proteins

8 July 2018

1 reference

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Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero

8 July 2018

1 reference

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2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

8 July 2018

1 reference

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The pathophysiology and treatment of sepsis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Intensive insulin therapy in critically ill patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

8 July 2018

1 reference

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Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

8 July 2018

1 reference

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The role of p38 mitogen-activated protein kinase in IL-1 beta transcription

8 July 2018

1 reference

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Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map.

8 July 2018

1 reference

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation

8 July 2018

1 reference

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K⁺ drops tilt the NLRP3 inflammasome.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Hypoglycemia and risk of death in critically ill patients

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Lipid synthesis in macrophages during inflammation in vivo: effect of agonists of peroxisome proliferator activated receptors alpha and gamma and of retinoid X receptors

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Glucose Control and Mortality in Critically Ill Patients

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319445

Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25574840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25574840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI78253

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25574840%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference