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Nuclear transport as a target for cell growth
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Nuclear transport as a target for cell growth
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
author
Pamela Silver
series ordinal
2
object named as
Pamela A Silver
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
author name string
Tweeny R Kau
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
publication date
1 January 2003
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
published in
Drug Discovery Today
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
volume
8
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
issue
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
page(s)
78-85
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
cites work
Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Nucleocytoplasmic transport: the last 200 nanometers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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inferred from DOI database lookup
Protein export from the nucleus
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reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
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inferred from DOI database lookup
Transport between the cell nucleus and the cytoplasm
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reference URL
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7 January 2021
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inferred from DOI database lookup
A new antitumor antibiotic, kazusamycin
1 reference
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reference URL
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7 January 2021
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Novel antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721. Taxonomy, fermentation and biological activity.
1 reference
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reference URL
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7 January 2021
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In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721).
1 reference
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7 January 2021
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Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells
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reference URL
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7 January 2021
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Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA
1 reference
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reference URL
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7 January 2021
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Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery
1 reference
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reference URL
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7 January 2021
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CRM1 is responsible for intracellular transport mediated by the nuclear export signal
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
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Evidence for a role of CRM1 in signal-mediated nuclear protein export
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
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inferred from DOI database lookup
CRM1 is an export receptor for leucine-rich nuclear export signals
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
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Exportin 1 (Crm1p) is an essential nuclear export factor
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
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Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1
1 reference
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reference URL
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7 January 2021
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Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
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inferred from DOI database lookup
Phase I trial of elactocin
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
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inferred from DOI database lookup
Accumulating active p53 in the nucleus by inhibition of nuclear export: a novel strategy to promote the p53 tumor suppressor function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear transport and transcription
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappaB in cancer: from innocent bystander to major culprit
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
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inferred from DOI database lookup
NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
1 reference
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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of TNF-alpha-induced apoptosis by NF-kappaB
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
An allosteric drug, o,o'-bismyristoyl thiamine disulfide, suppresses HIV-1 replication through prevention of nuclear translocation of both HIV-1 Tat and NF-kappa B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of tumor necrosis factor-alpha -induced nuclear translocation and activation of NF-kappa B by dehydroxymethylepoxyquinomicin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis of NF-kappaB activation inhibitors derived from epoxyquinomicin C
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation and function of the p53 tumor suppressor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 RING-finger domain is required to promote p53 nuclear export
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 in cervical carcinoma cells by small molecules.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide kinases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular survival: a play in three Akts
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of translocation in the activation and function of protein kinase B
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct control of the Forkhead transcription factor AFX by protein kinase B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An artificial cell-cycle inhibitor isolated from a combinatorial library
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted modification and transportation of cellular proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902562-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1359-6446(02)02562-X
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
PubMed ID
12565010
1 reference
stated in
Europe PubMed Central
PubMed ID
12565010
retrieved
6 August 2017
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