(Q35063700)

6 August 2017

title

Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus (English)

1 reference

6 August 2017

1

Gurdeep Marwarha

1 reference

6 August 2017

Jaya Rp Prasanthi

2

1 reference

6 August 2017

Jared Schommer

series ordinal

3

1 reference

6 August 2017

Bhanu Dasari

series ordinal

4

1 reference

6 August 2017

Othman Ghribi

series ordinal

5

1 reference

6 August 2017

publication date

8 June 2011

1 reference

Molecular Neurodegeneration

6 August 2017

published in

1 reference

6 August 2017

volume

6

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6 August 2017

issue

1

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6 August 2017

page(s)

41

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β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway

6 August 2017

cites work

1 reference

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IGF-1 stimulates protein synthesis by enhanced signaling through mTORC1 in bovine mammary epithelial cells

8 July 2018

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Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices

8 July 2018

1 reference

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Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells

8 July 2018

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Leptin: a novel therapeutic strategy for Alzheimer's disease

8 July 2018

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Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

8 July 2018

1 reference

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Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells

8 July 2018

1 reference

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The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid

8 July 2018

1 reference

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Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation

8 July 2018

1 reference

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Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells

8 July 2018

1 reference

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The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid

8 July 2018

1 reference

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Growth hormone regulation of insulin-like growth factor-I gene expression may be mediated by multiple distal signal transducer and activator of transcription 5 binding sites

8 July 2018

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Discovery of chromone-based inhibitors of the transcription factor STAT5.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Intracellular amyloid-beta in Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Hypoxia activates the IGF-1 expression through STAT5b in human HepG2 cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Regulation of adipocyte differentiation and insulin action with rapamycin.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Mechanisms by which IGF-I may promote cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

CCAAT/enhancer-binding proteins: structure, function and regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Leptin immunoreactivity is localized to neurons in rat brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Serum growth factors and neuroprotective surveillance: focus on IGF-1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Translational control of C/EBPalpha and C/EBPbeta isoform expression.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Leptin action in intestinal cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Adipocyte differentiation and leptin expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

TRANSFAC, TRRD and COMPEL: towards a federated database system on transcriptional regulation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Defective STAT signaling by the leptin receptor in diabetic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Phylogenetic position of the order Lagomorpha (rabbits, hares and allies)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Insulin-like growth factor receptors. Implications for nervous system function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Control of p70 s6 kinase by kinase activity of FRAP in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Differential expression of insulin-like growth factor genes in rat central nervous system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Localization of insulin-like growth factor-1 mRNA in murine central nervous system during postnatal development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease.

8 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Use of serum insulin-like growth factor-I levels to predict psychiatric non-response to donepezil in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Leptin immunoreactivity in the central nervous system in normal and diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Circulating leptin levels and weight loss in Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Specific uptake of Aβ1-40 in rat brain occurs in astrocyte, but not in microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Protective and rescuing abilities of IGF-I and some putative free radical scavengers against beta-amyloid-inducing toxicity in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Beta-amyloid peptide toxicity in organotypic hippocampal slice culture involves Akt/PKB, GSK-3beta, and PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Amyloid-beta interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Serum insulin-like growth factor I regulates brain amyloid-beta levels

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Leptin, peroxisome proliferator-activated receptor-gamma, and CCAAT/enhancer binding protein-alpha mRNA expression in adipose tissue of humans and their relation to cardiovascular risk factors.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

Insulin-like growth factors cross the blood-brain barrier

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121598

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

27 September 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-6-41

Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons

21 January 2018

1 reference

12 December 2020

Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers

1 reference

12 December 2020

Beyond nutrition: neuropeptide signaling and muscle mass maintenance in chronic kidney disease

1 reference

12 December 2020

Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor

1 reference

12 December 2020

Identifiers

DOI

10.1186/1750-1326-6-41

1 reference

Dimensions Publication ID

6 August 2017

0 references

1 reference

6 August 2017

1 reference