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HIV-1 integrase strand transfer inhibitors stabilize an integrase-single blunt-ended DNA complex
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PMC publication ID
3123398
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21295584%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
title
HIV-1 integrase strand transfer inhibitors stabilize an integrase-single blunt-ended DNA complex
(English)
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PMC publication ID
3123398
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21295584%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
author
Krishan K Pandey
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2
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3123398
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21 January 2020
author name string
Sibes Bera
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1
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PMC publication ID
3123398
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21295584%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
Ajaykumar C Vora
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3
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3123398
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21 January 2020
Duane P Grandgenett
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4
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3123398
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21 January 2020
language of work or name
English
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publication date
3 February 2011
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Europe PubMed Central
PMC publication ID
3123398
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retrieved
21 January 2020
number of pages
16
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published in
Journal of Molecular Biology
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Europe PubMed Central
PMC publication ID
3123398
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21295584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
volume
410
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Europe PubMed Central
PMC publication ID
3123398
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21 January 2020
issue
5
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Europe PubMed Central
PMC publication ID
3123398
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21295584%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
page(s)
831-846
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Europe PubMed Central
PMC publication ID
3123398
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21295584%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
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The mechanism of retroviral integration from X-ray structures of its key intermediates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Physical trapping of HIV-1 synaptic complex by different structural classes of integrase strand transfer inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Structure-based modeling of the functional HIV-1 intasome and its inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Retroviral intasome assembly and inhibition of DNA strand transfer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Molecular Interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Characterization and structural analysis of HIV-1 integrase conservation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Nucleoprotein complex intermediates in HIV-1 integration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Biochemical and biophysical analyses of concerted (U5/U3) integration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Functional and structural characterization of the integrase from the prototype foamy virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Raltegravir with optimized background therapy for resistant HIV-1 infection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Mechanisms of human immunodeficiency virus type 1 concerted integration related to strand transfer inhibition and drug resistance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Inhibition of human immunodeficiency virus type 1 concerted integration by strand transfer inhibitors which recognize a transient structural intermediate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Retroviral DNA integration: reaction pathway and critical intermediates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Synaptic complex formation of two retrovirus DNA attachment sites by integrase: a fluorescence energy transfer study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Recombinant human immunodeficiency virus type 1 integrase exhibits a capacity for full-site integration in vitro that is comparable to that of purified preintegration complexes from virus-infected cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Integrase inhibitors to treat HIV/AIDS.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
HIV-1 integrase crosslinked oligomers are active in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Efficient concerted integration by recombinant human immunodeficiency virus type 1 integrase without cellular or viral cofactors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Asymmetric processing of human immunodeficiency virus type 1 cDNA in vivo: implications for functional end coupling during the chemical steps of DNA transposition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Concerted integration of retrovirus-like DNA by human immunodeficiency virus type 1 integrase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Integration of human immunodeficiency virus type 1 DNA in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
8 July 2018
Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
27 September 2018
The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
27 September 2018
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
27 September 2018
Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
27 September 2018
Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
27 September 2018
Disruption of the terminal base pairs of retroviral DNA during integration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123398
retrieved
27 September 2018
Identifiers
DOI
10.1016/J.JMB.2011.01.043
1 reference
stated in
Europe PubMed Central
PMC publication ID
3123398
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21295584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
PMC publication ID
3123398
1 reference
stated in
Europe PubMed Central
PMC publication ID
3123398
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21295584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
PubMed publication ID
21295584
1 reference
stated in
Europe PubMed Central
PMC publication ID
3123398
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21295584%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
ResearchGate publication ID
49811908
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