(Q35071136)

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Oral leucine supplementation is sensed by the brain but neither reduces food intake nor induces an anorectic pattern of gene expression in the hypothalamus.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24349566%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Oral leucine supplementation is sensed by the brain but neither reduces food intake nor induces an anorectic pattern of gene expression in the hypothalamus (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24349566%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

João A B Pedroso

2

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3 March 2020

5

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3 March 2020

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Thais T Zampieri

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3 March 2020

Isadora C Furigo

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3 March 2020

Julio Tirapegui

4

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3 March 2020

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13 December 2013

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3 March 2020

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3 March 2020

8

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3 March 2020

12

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3 March 2020

e84094

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3 March 2020

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Creative Commons Attribution 4.0 International

13 December 2013

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Europe PubMed Central

11 June 2022

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Leucine supplementation protects from insulin resistance by regulating adiposity levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Central nervous system control of metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Leucine improves glucose and lipid status in offspring from obese dams, dependent on diet type, but not caloric intake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Hypothalamic mTOR signaling regulates food intake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Potential importance of leucine in treatment of obesity and the metabolic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

The role of leucine in the regulation of protein metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Mechanisms responsible for regulation of branched-chain amino acid catabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

The role of leucine in weight loss diets and glucose homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Anatomical markers of activity in neuroendocrine systems: are we all 'fos-ed out'?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Brain glucose sensing and body energy homeostasis: role in obesity and diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Absence of lithium-induced taste aversion after area postrema lesion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Area postrema mediation of physiological and behavioral effects of lithium chloride in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

8 July 2018

Effect of central and peripheral leucine on energy metabolism in the Djungarian hamster (Phodopus sungorus).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Lipid sensing and insulin resistance in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Leucine is essential for attenuating fetal growth restriction caused by a protein-restricted diet in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Leucine supplementation favors liver protein status but does not reduce body fat in rats during 1 week of food restriction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Male and female odors induce Fos expression in chemically defined neuronal population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Supplementation with dietary leucine to a protein-deficient diet suppresses myofibrillar protein degradation in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Effects of leucine and phenylalanine supplementation during intermittent periods of food restriction and refeeding in adult rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Taste aversions conditioned with intravenous copper sulfate: Attenuation by ablation of the area postrema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862776

27 September 2018

Regulation of branched-chain alpha-ketoacid dehydrogenase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucine-supplemented meal feeding for ten days beneficially affects postprandial muscle protein synthesis in old rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adverse effects of excessive leucine intake depend on dietary protein intake: a transcriptomic analysis to identify useful biomarkers

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of central orexin/hypocretin neurons by dietary amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/24349566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0084094

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24349566%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

2013PLoSO...884094Z

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24349566%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24349566%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

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