(Q35078225)

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Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients

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scholarly article

1 reference

Europe PubMed Central

6 August 2017

Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients (English)

1 reference

Europe PubMed Central

6 August 2017

multiple sclerosis

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Carla J Greenbaum

8

object named as

Carla Greenbaum

1 reference

Europe PubMed Central

6 August 2017

author name string

Karen Cerosaletti

1

1 reference

Europe PubMed Central

6 August 2017

Anya Schneider

2

1 reference

Europe PubMed Central

6 August 2017

Katharine Schwedhelm

3

1 reference

Europe PubMed Central

6 August 2017

Ian Frank

4

1 reference

Europe PubMed Central

6 August 2017

Megan Tatum

5

1 reference

Europe PubMed Central

6 August 2017

Shan Wei

6

1 reference

Europe PubMed Central

6 August 2017

Elizabeth Whalen

7

1 reference

Europe PubMed Central

6 August 2017

Mariko Kita

9

1 reference

Europe PubMed Central

6 August 2017

Jane Buckner

10

1 reference

Europe PubMed Central

6 August 2017

S Alice Long

11

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Europe PubMed Central

6 August 2017

language of work or name

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publication date

23 December 2013

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Europe PubMed Central

6 August 2017

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Europe PubMed Central

6 August 2017

8

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Europe PubMed Central

6 August 2017

12

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Europe PubMed Central

6 August 2017

e83811

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Europe PubMed Central

6 August 2017

copyright license

Creative Commons Attribution 4.0 International

23 December 2013

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April 2022 Public Data File from Crossref

copyright status

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Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Soluble IL-2Rα (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Central role for interleukin-2 in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Interleukin-2 receptor signaling: at the interface between tolerance and immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Transcriptional regulation of IL-2 in health and autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Protein tyrosine phosphatases in autoimmunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

The biology of interleukin-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Risk alleles for multiple sclerosis identified by a genomewide study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

The dichotomous role of IL-2: tolerance versus immunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

The molecular basis for the generation of the human soluble interleukin 2 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

8 July 2018

Murine mesenchymal stem cells suppress T lymphocyte activation through IL-2 receptor α (CD25) cleavage by producing matrix metalloproteinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

27 September 2018

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

27 September 2018

IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

27 September 2018

Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

27 September 2018

IL-2 receptor alpha deficiency and features of primary biliary cirrhosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

27 September 2018

A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

27 September 2018

A cis-Acting Regulatory Variant in the IL2RA Locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871703

16 November 2018

A variant of the Il2ra / Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/24376757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/24376757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0083811

1 reference

Europe PubMed Central

6 August 2017

2013PLoSO...883811C

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1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

6 August 2017

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