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Beta-secretase activity increases with aging in human, monkey, and mouse brain.
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Europe PubMed Central
PMCID
1602259
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 November 2019
title
Beta-secretase activity increases with aging in human, monkey, and mouse brain
(English)
1 reference
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Europe PubMed Central
PMCID
1602259
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
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17 November 2019
author
Douglas L. Rosene
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2
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Europe PubMed Central
PMCID
1602259
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
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17 November 2019
Mark Moss
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3
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PMCID
1602259
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
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17 November 2019
Bradley Hyman
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5
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Bradley T Hyman
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1602259
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 November 2019
author name string
Hiroaki Fukumoto
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1
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1602259
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17 November 2019
Susan Raju
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4
1 reference
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Europe PubMed Central
PMCID
1602259
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
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17 November 2019
Michael C Irizarry
series ordinal
6
1 reference
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Europe PubMed Central
PMCID
1602259
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
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17 November 2019
language of work or name
English
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publication date
1 February 2004
1 reference
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Europe PubMed Central
PMCID
1602259
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retrieved
17 November 2019
published in
The American Journal of Pathology
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1602259
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
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17 November 2019
volume
164
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Europe PubMed Central
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1602259
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17 November 2019
issue
2
1 reference
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Europe PubMed Central
PMCID
1602259
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 November 2019
page(s)
719-725
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Europe PubMed Central
PMCID
1602259
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 November 2019
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The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain
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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
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Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes
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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
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Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.
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27 September 2018
Oxidative stress increases expression and activity of BACE in NT2 neurons
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27 September 2018
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
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27 September 2018
Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
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27 September 2018
BACE1 interacts with nicastrin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
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27 September 2018
Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
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27 September 2018
Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
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27 September 2018
Age-related changes in the localization of presenilin-1 in cynomolgus monkey brain
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
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27 September 2018
Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
retrieved
27 September 2018
Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
retrieved
27 September 2018
Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
retrieved
27 September 2018
APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
retrieved
27 September 2018
Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
retrieved
27 September 2018
The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta42(43).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1602259
retrieved
27 September 2018
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963159-8
retrieved
7 January 2021
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963159-8
retrieved
7 January 2021
Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963159-8
retrieved
7 January 2021
Identifiers
DOI
10.1016/S0002-9440(10)63159-8
1 reference
stated in
Europe PubMed Central
PMCID
1602259
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 November 2019
PMCID
1602259
1 reference
stated in
Europe PubMed Central
PMCID
1602259
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 November 2019
PubMed ID
14742275
1 reference
stated in
Europe PubMed Central
PMCID
1602259
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 November 2019
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