(Q35096123)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

review article

1 reference

title

Molecular pathways in cerebral ischemia: cues to novel therapeutic strategies (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

Brigitte Onténiente

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Sowmyalakshmí Rasika

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Christelle Guégan

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

publication date

1 February 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

published in

Molecular Neurobiology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

page(s)

33-72

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12668901%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1385/mn:27:1:33

2 November 2019

exact match

0 references

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Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation.

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Why are some neurons replaced in adult brain?

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Randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe, Australia, and New Zealand

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Changes in extracellular amino acids and spontaneous neuronal activity during ischemia and extended reflow in the CA1 of the rat hippocampus.

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12 December 2020

Caspases and caspase inhibitors

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12 December 2020

BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia

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12 December 2020

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

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12 December 2020

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

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12 December 2020

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'.

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12 December 2020

Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus

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12 December 2020

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

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12 December 2020

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

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12 December 2020

Cognitive deficits induced by global cerebral ischaemia: prospects for transplant therapy

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12 December 2020

The IVH complex of lesions: cerebrovascular injury in the preterm infant.

1 reference

12 December 2020

Serial killers: ordering caspase activation events in apoptosis

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12 December 2020

Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat

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12 December 2020

Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

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12 December 2020

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease.

1 reference

12 December 2020

Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells.

1 reference

12 December 2020

Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat.

1 reference

12 December 2020

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1 reference

12 December 2020

Cell death: the significance of apoptosis

1 reference

12 December 2020

Glutamate antagonist MK-801 attenuates incomplete but not complete infarction in thrombotic distal middle cerebral artery occlusion in Wistar rats

1 reference

12 December 2020

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

12 December 2020

mu-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage.

1 reference

12 December 2020

Calcium and long-term transmission damage following anoxia in dentate gyrus and CA1 regions of the rat hippocampal slice

1 reference

12 December 2020

Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients.

1 reference

12 December 2020

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1 reference

12 December 2020

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1 reference

12 December 2020

Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats

1 reference

12 December 2020

Isolation, characterization, and use of stem cells from the CNS.

1 reference

12 December 2020

The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat

1 reference

12 December 2020

A selective N-type Ca(2+)-channel blocker prevents CA1 injury 24 h following severe forebrain ischemia and reduces infarction following focal ischemia

1 reference

12 December 2020

ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis

1 reference

12 December 2020

Overexpression of the cell death suppressor Bcl-w in ischemic brain: implications for a neuroprotective role via the mitochondrial pathway

1 reference

12 December 2020

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

1 reference

12 December 2020

Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils.

1 reference

12 December 2020

Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents.

1 reference

12 December 2020

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

12 December 2020

A reproducible model of middle cerebral artery occlusion in mice: hemodynamic, biochemical, and magnetic resonance imaging

1 reference

12 December 2020

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

1 reference

12 December 2020

Mitochondria as the central control point of apoptosis

1 reference

12 December 2020

Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex

1 reference

12 December 2020

Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke.

1 reference

12 December 2020

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

1 reference

12 December 2020

Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury.

1 reference

12 December 2020

Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial

1 reference

12 December 2020

Neurological emergencies: acute stroke

1 reference

12 December 2020

Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats.

1 reference

12 December 2020

Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia.

1 reference

12 December 2020

PACAP action in nervous system development, regeneration, and neuroblastoma cell proliferation.

1 reference

12 December 2020

Caspases determine the vulnerability of oligodendrocytes in the ischemic brain

1 reference

12 December 2020

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1 reference

12 December 2020

Flunarizine, a calcium entry blocker, ameliorates ischemic brain damage in the rat.

1 reference

12 December 2020

The adult rat hippocampus contains primordial neural stem cells

1 reference

12 December 2020

Programmed cell death regulation: basic mechanisms and therapeutic opportunities

1 reference

12 December 2020

Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

12 December 2020

TR3 death receptor expression in the normal and ischaemic brain.

1 reference

12 December 2020

Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum.

1 reference

12 December 2020

High sensitivity of protoplasmic cortical astroglia to focal ischemia.

1 reference

12 December 2020

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

1 reference

12 December 2020

PI3K: downstream AKTion blocks apoptosis

1 reference

12 December 2020

Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury

1 reference

12 December 2020

Inhibition of caspase activity induces a switch from apoptosis to necrosis

1 reference

12 December 2020

Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia.

1 reference

12 December 2020

The effects of a competitive NMDA receptor antagonist (CGS-19755) on cerebral blood flow and pH in focal ischemia.

1 reference

12 December 2020

Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis

1 reference

12 December 2020

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

1 reference

12 December 2020

Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells

1 reference

12 December 2020

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor.

1 reference

12 December 2020

Mitochondrial release of caspase-2 and -9 during the apoptotic process

1 reference

12 December 2020

Reasons why stroke trials underestimate the neuroprotective effects of drugs

1 reference

12 December 2020

Transport of pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier and the prevention of ischemia-induced death of hippocampal neurons.

1 reference

12 December 2020

ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

1 reference

12 December 2020

Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons.

1 reference

12 December 2020

Riluzole prevents ischemic spinal cord injury caused by aortic crossclamping.

1 reference

12 December 2020

De novo generation of neuronal cells from the adult mouse brain

1 reference

12 December 2020

Caspase mRNA expression in a rat model of focal cerebral ischemia.

1 reference

12 December 2020

Calcineurin and mitochondrial function in glutamate-induced neuronal cell death.

1 reference

12 December 2020

The CARD domain: a new apoptotic signalling motif

1 reference

12 December 2020

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

1 reference

12 December 2020

Increased neurogenesis in a model of electroconvulsive therapy

1 reference

12 December 2020

Nitric oxide can inhibit apoptosis or switch it into necrosis

1 reference

12 December 2020

Caspases: enemies within

1 reference

12 December 2020

Neuroprotective effect of memantine demonstrated in vivo and in vitro.

1 reference

12 December 2020

Nimodipine attenuates both increase in cytosolic free calcium and histologic damage following focal cerebral ischemia and reperfusion in cats

1 reference

12 December 2020

Caspases: killer proteases

1 reference

12 December 2020

The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687,414) in a rat model of focal ischaemia

1 reference

12 December 2020

Cold thoughts of death: the role of ICE proteases in neuronal cell death

1 reference

12 December 2020

Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss

1 reference

12 December 2020

Neurotrophic factor therapy for nervous system degenerative diseases

1 reference

12 December 2020

Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation.

1 reference

12 December 2020

Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia.

1 reference

12 December 2020

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

12 December 2020

Neural grafting to ischemic CA1 lesions in the rat hippocampus: an autoradiographic study

1 reference

12 December 2020

Mitochondria and apoptosis

1 reference

12 December 2020

Inhibition of distant caspase homologues by natural caspase inhibitors

1 reference

12 December 2020

Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism.

1 reference

12 December 2020

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

1 reference

12 December 2020

Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death

1 reference

12 December 2020

A selective cysteine protease inhibitor is non-toxic and cerebroprotective in rats undergoing transient middle cerebral artery ischemia

1 reference

12 December 2020

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1 reference

12 December 2020

Astrocytes give rise to new neurons in the adult mammalian hippocampus.

1 reference

12 December 2020

The early events of oxygen and glucose deprivation: setting the scene for neuronal death?

1 reference

12 December 2020

Cerebroprotective effect of lamotrigine after focal ischemia in rats

1 reference

12 December 2020

Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat.

1 reference

12 December 2020

Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

1 reference

12 December 2020

Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.

1 reference

12 December 2020

Use-dependent growth of pyramidal neurons after neocortical damage.

1 reference

12 December 2020

New prospects for human stem-cell therapy in the nervous system

1 reference

12 December 2020

Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

1 reference

12 December 2020

Apoptosis by death factor

1 reference

12 December 2020

Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.

1 reference

12 December 2020

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

12 December 2020

The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study.

1 reference

12 December 2020

Cortical neurogenesis in adult rats after transient middle cerebral artery occlusion

1 reference

12 December 2020

Two CD95 (APO-1/Fas) signaling pathways

1 reference

12 December 2020

Co-existence of necrosis and apoptosis in rat hippocampus following transient forebrain ischemia

1 reference

12 December 2020

Apoptosis and necrosis: different execution of the same death

1 reference

12 December 2020

Bax directly induces release of cytochrome c from isolated mitochondria

1 reference

12 December 2020

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

1 reference

12 December 2020

Extracellular neuroactive amino acids in the rat striatum during ischaemia: comparison between penumbral conditions and ischaemia with sustained anoxic depolarisation.

1 reference

12 December 2020

Pre- and postischemic effects of the NMDA receptor antagonist dizocilpine maleate (MK-801) on collateral cerebral blood flow.

1 reference

12 December 2020

Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury

1 reference

12 December 2020

Termination of Acute Stroke Studies Involving Selfotel Treatment. ASSIST Steering Committed

1 reference

12 December 2020

Caspases disrupt mitochondrial membrane barrier function.

1 reference

12 December 2020

Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain

1 reference

12 December 2020

Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex

1 reference

12 December 2020

The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death

1 reference

12 December 2020

Protective effect of nimodipine against ischemic neuronal damage in rat hippocampus without changing postischemic cerebral blood flow

1 reference

12 December 2020

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

12 December 2020

Expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 after focal cerebral ischemia in interleukin-1beta converting enzyme deficient mice

1 reference

12 December 2020

Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

1 reference

12 December 2020

Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning

1 reference

12 December 2020

IAP family proteins--suppressors of apoptosis

1 reference

12 December 2020

Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro

1 reference

12 December 2020

Calcium antagonists and vasospasm

1 reference

12 December 2020

The mitochondrial permeability transition.

1 reference

12 December 2020

Bcl-2 promotes regeneration of severed axons in mammalian CNS

1 reference

12 December 2020

Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells

1 reference

12 December 2020

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

1 reference

12 December 2020

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

1 reference

12 December 2020

Opposing mitogenic regulation by PACAP in sympathetic and cerebral cortical precursors correlates with differential expression of PACAP receptor (PAC1-R) isoforms.

1 reference

12 December 2020

Flunarizine in acute ischemic stroke: a pilot study

1 reference

12 December 2020

1 reference

12 December 2020

Ischemic flow threshold for extracellular glutamate increase in cat cortex

1 reference

12 December 2020

The competitive NMDA antagonist CGP 40116 permanently reduces brain damage after middle cerebral artery occlusion in rats

1 reference

12 December 2020

Noggin antagonizes BMP signaling to create a niche for adult neurogenesis

1 reference

12 December 2020

Neurotrophic factors: from molecule to man.

1 reference

12 December 2020

Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide.

1 reference

12 December 2020

Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB

1 reference

12 December 2020

Survival- and death-promoting events after transient cerebral ischemia: phosphorylation of Akt, release of cytochrome C and Activation of caspase-like proteases

1 reference

12 December 2020

Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning

1 reference

12 December 2020

Specific caspase pathways are activated in the two stages of cerebral infarction.

1 reference

12 December 2020

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

12 December 2020

Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism

1 reference

12 December 2020

Neuroprotection in acute ischaemic stroke. II: Clinical potential

1 reference

12 December 2020

Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

1 reference

12 December 2020

On the status of lysolecithin in rat cerebral cortex during ischemia.

1 reference

12 December 2020

Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain

1 reference

12 December 2020

Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia

1 reference

12 December 2020

Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.

1 reference

12 December 2020

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

12 December 2020

Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage.

1 reference

12 December 2020

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

12 December 2020

Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

1 reference

12 December 2020

Trafermin. CAB 2001, KCB 1, Fiblast

1 reference

12 December 2020

The validity of a simple clinical classification of acute ischaemic stroke.

1 reference

12 December 2020

Lidocaine protects hippocampal neurons against ischemic damage by preventing increase of extracellular excitatory amino acids: a microdialysis study in Mongolian gerbils.

1 reference

12 December 2020

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

1 reference

12 December 2020

Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerebral ischemia in the cat.

1 reference

12 December 2020

Caspases: the proteases of the apoptotic pathway

1 reference

12 December 2020

Cathepsin B-mediated activation of the proinflammatory caspase-11.

1 reference

12 December 2020

Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats.

1 reference

12 December 2020

Human ICE/CED-3 protease nomenclature

1 reference

12 December 2020

IL-10-mediated suppression of TNF-alpha production is independent of its ability to inhibit NF kappa B activity

1 reference

12 December 2020

Sex and seasonal differences in the rate of cell proliferation in the dentate gyrus of adult wild meadow voles.

1 reference

12 December 2020

Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion.

1 reference

12 December 2020

CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons.

1 reference

12 December 2020

Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

1 reference

12 December 2020

Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation.

1 reference

12 December 2020

Long-term outcome of unilaterally transplanted parkinsonian patients. I. Clinical approach.

1 reference

12 December 2020

Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat

1 reference

12 December 2020

Neurogenesis following brain ischemia

1 reference

12 December 2020

Suppression of endogenous bcl-2 expression by antisense treatment exacerbates ischemic neuronal death

1 reference

12 December 2020

Stem cells in the central nervous system

1 reference

12 December 2020

The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis

1 reference

12 December 2020

Remacemide hydrochloride: a double-blind, placebo-controlled, safety and tolerability study in patients with acute ischemic stroke

1 reference

12 December 2020

Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice

1 reference

12 December 2020

The neurotrophin receptor p75 binds neurotrophin-3 on sympathetic neurons with high affinity and specificity

1 reference

12 December 2020

Nimodipine prevents delayed neuronal death of sector CA1 pyramidal cells in short-term forebrain ischemia in Mongolian gerbils.

1 reference

12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

12 December 2020

Glutamate release in severe brain ischaemia is mainly by reversed uptake.

1 reference

12 December 2020

The central executioners of apoptosis: caspases or mitochondria?

1 reference

12 December 2020

Role and mechanisms of secondary mitochondrial failure.

1 reference

12 December 2020

An induced proximity model for caspase-8 activation.

1 reference

12 December 2020

Focal cerebral ischemia in the cat: pretreatment with a competitive NMDA receptor antagonist, D-CPP-ene

1 reference

12 December 2020

Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo

1 reference

12 December 2020

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

1 reference

12 December 2020

Very Early Nimodipine Use in Stroke (VENUS): a randomized, double-blind, placebo-controlled trial

1 reference

12 December 2020

Upregulation of bax protein levels in neurons following cerebral ischemia.

1 reference

12 December 2020

Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis.

1 reference

12 December 2020

A selective N-type calcium channel antagonist reduces extracellular glutamate release and infarct volume in focal cerebral ischemia

1 reference

12 December 2020

Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell.

1 reference

12 December 2020

The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders

1 reference

12 December 2020

Increased expression of IL-1beta converting enzyme in hippocampus after ischemia: selective localization in microglia

1 reference

12 December 2020

Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain

1 reference

12 December 2020

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

12 December 2020

Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells.

1 reference

12 December 2020

Trophic factors and neuronal survival

1 reference

12 December 2020

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

1 reference

12 December 2020

Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat.

1 reference

12 December 2020

Long-distance neuronal migration in the adult mammalian brain

1 reference

12 December 2020

Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo

1 reference

12 December 2020

A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia

1 reference

12 December 2020

Roles of Bcl-2 and caspases in hypoxia-induced neuronal cell death: a possible neuroprotective mechanism of peptide growth factors.

1 reference

12 December 2020

Immunohistochemical investigation of caspase-1 and effect of caspase-1 inhibitor in delayed neuronal death after transient cerebral ischemia

1 reference

12 December 2020

A comparison of cathepsin B processing and distribution during neuronal death in rats following global ischemia or decapitation necrosis.

1 reference

12 December 2020

Flunarizine in stroke treatment (FIST): a double-blind, placebo-controlled trial in Scandinavia and the Netherlands

1 reference

12 December 2020

Caspases: intracellular signaling by proteolysis

1 reference

12 December 2020

Are new neurons formed in the brains of adult mammals?

1 reference

12 December 2020

Enhanced calcium uptake by CA1 pyramidal cell dendrites in the postischemic phase despite subnormal evoked field potentials: excitatory amino acid receptor dependency and relationship to neuronal damage.

1 reference

12 December 2020

Stem cells. Breaking the brain-blood barrier.

1 reference

12 December 2020

Molecular cloning of the interleukin-1 beta converting enzyme

1 reference

12 December 2020

Oxidative stress in brain ischemia.

1 reference

12 December 2020

The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils.

1 reference

12 December 2020

Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor

1 reference

12 December 2020

Recruitment of several neuroprotective pathways after permanent focal ischemia in mice.

1 reference

12 December 2020

FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain

1 reference

12 December 2020

Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

1 reference

12 December 2020

Transplantation of cultured human neuronal cells for patients with stroke

1 reference

12 December 2020

The proteolytic procaspase activation network: an in vitro analysis.

1 reference

12 December 2020

Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by R(-)-deprenyl.

1 reference

12 December 2020

Structural complexity and functional diversity of endoplasmic reticulum Ca(2+) stores

1 reference

12 December 2020

Inhibition of caspases prevents cell death of hippocampal CA1 neurons, but not impairment of hippocampal long-term potentiation following global ischemia.

1 reference

12 December 2020

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1 reference

12 December 2020

Prevention of apoptotic neuronal death by controlling procaspases? A point of view

1 reference

12 December 2020

Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

1 reference

12 December 2020

Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus.

1 reference

12 December 2020

Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia.

1 reference

12 December 2020

Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory.

1 reference

12 December 2020

Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest.

1 reference

12 December 2020

Calcium-related damage in ischemia

1 reference

12 December 2020

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

12 December 2020

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

1 reference

12 December 2020

Neuroprotective effect of YM90K, a novel AMPA/kainate receptor antagonist, in focal cerebral ischemia in cats.

1 reference

12 December 2020

Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

1 reference

12 December 2020

Inhibition of fas death signals by FLIPs

1 reference

12 December 2020

The effect of the excitatory amino acid receptor antagonist dizocilipine maleate (MK-801) on hemispheric cerebral blood flow and metabolism in dogs: modification by prior complete cerebral ischemia

1 reference

12 December 2020

Cell replacement therapies for central nervous system disorders.

1 reference

12 December 2020

Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat.

1 reference

12 December 2020

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1 reference

12 December 2020

Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy.

1 reference

12 December 2020

A caspase inhibitor blocks ischaemia-induced delayed neuronal death in the gerbil.

1 reference

12 December 2020

Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory.

1 reference

12 December 2020

Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors

1 reference

12 December 2020

Origin of ischemia-induced glutamate efflux in the CA1 field of the gerbil hippocampus: an in vivo brain microdialysis study

1 reference

12 December 2020

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1 reference

12 December 2020

BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy

1 reference

12 December 2020

Programmed cell death of embryonic motoneurons triggered through the Fas death receptor

1 reference

12 December 2020

Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis

1 reference

12 December 2020

Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage

1 reference

12 December 2020

Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus.

1 reference

12 December 2020

Intraischemic hypothermia decreases the release of glutamate in the cores of permanent focal cerebral infarcts

1 reference

12 December 2020

YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats.

1 reference

12 December 2020

Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion.

1 reference

12 December 2020

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1 reference

12 December 2020

Genetically modified fibroblasts producing NGF protect hippocampal neurons after ischemia in the rat.

1 reference

12 December 2020

An in vitro model for the study of microglia-induced neurodegeneration: involvement of nitric oxide and tumor necrosis factor-alpha

1 reference

12 December 2020

Genetic influence on neurogenesis in the dentate gyrus of adult mice

1 reference

12 December 2020

The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site

1 reference

12 December 2020

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1 reference

12 December 2020

Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death

1 reference

12 December 2020

Loss of function of cytochrome c in Jurkat cells undergoing fas-mediated apoptosis

1 reference

12 December 2020

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1 reference

12 December 2020

Cytosolic Ca2+ changes during in vitro ischemia in rat hippocampal slices: major roles for glutamate and Na+-dependent Ca2+ release from mitochondria.

1 reference

12 December 2020

Caspase-10 is an initiator caspase in death receptor signaling

1 reference

12 December 2020

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.

1 reference

12 December 2020

Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells

1 reference

12 December 2020

Neurogenesis in adult subventricular zone.

1 reference

12 December 2020

Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.

1 reference

12 December 2020

Threshold of calcium disturbances after focal cerebral ischemia in rats. Implications of the window of therapeutic opportunity.

1 reference

12 December 2020

Prevention of periinfarct direct current shifts with glutamate antagonist NBQX following occlusion of the middle cerebral artery in the rat

1 reference

12 December 2020

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

1 reference

12 December 2020

Amelioration of ischaemia-induced neuronal death in the rat striatum by NGF-secreting neural stem cells.

1 reference

12 December 2020

Mitochondria as target for antiischemic drugs

1 reference

12 December 2020

The temporal relationship between protein phosphatase, mitochondrial cytochrome c release, and caspase activation in apoptosis

1 reference

12 December 2020

Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death

1 reference

12 December 2020

Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.

1 reference

12 December 2020

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

1 reference

12 December 2020

Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway

1 reference

12 December 2020

Ischemic cell death in brain neurons

1 reference

12 December 2020

Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA1 pyramidal neurons.

1 reference

12 December 2020

Sequential bilateral transplantation in Parkinson's disease: effects of the second graft.

1 reference

12 December 2020

BAX is required for neuronal death after trophic factor deprivation and during development

1 reference

12 December 2020

Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family.

1 reference

12 December 2020

Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

1 reference

12 December 2020

Cortical lesions induce an increase in cell number and PSA-NCAM expression in the subventricular zone of adult rats

1 reference

12 December 2020

Caspases: their intracellular localization and translocation during apoptosis.

1 reference

12 December 2020

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis.

1 reference

12 December 2020

1 reference

12 December 2020

Neuroprotection by MK-801 in temperature maintained gerbils.

1 reference

12 December 2020

The GluR2 (GluRB) hypothesis in ischemia: missing links.

1 reference

12 December 2020

High-dose tirilazad for acute stroke (RANTTAS II). RANTTAS II Investigators

1 reference

12 December 2020

PACAP functions as a neurotrophic factor

1 reference

12 December 2020

Cyclosporine A-induced oxidative stress in rat hepatocytes

1 reference

12 December 2020

Pro-caspase-3 is a major physiologic target of caspase-8.

1 reference

12 December 2020

Detection of caspase-9 activation in the cell death of the Bcl-x-deficient mouse embryo nervous system by cleavage sites-directed antisera

1 reference

12 December 2020

Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice.

1 reference

12 December 2020

Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat.

1 reference

12 December 2020

p75 neurotrophin receptor is required for constitutive and NGF-induced survival signalling in PC12 cells and rat hippocampal neurones.

1 reference

12 December 2020

[Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils]

1 reference

12 December 2020

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

12 December 2020

Early and sequential recruitment of apoptotic effectors after focal permanent ischemia in mice

1 reference

12 December 2020

Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group

1 reference

12 December 2020

X-linked IAP is a direct inhibitor of cell-death proteases

1 reference

12 December 2020

Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism

1 reference

12 December 2020

Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice

1 reference

12 December 2020

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1 reference

12 December 2020

Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury

1 reference

12 December 2020

Disease, transplantation and regeneration

1 reference

12 December 2020

Neurogenesis in the adult human hippocampus

1 reference

12 December 2020

Schwann cell invasion of the central nervous system of the myelin mutants

1 reference

12 December 2020

The role of early Ca2+ influx in the pathogenesis of delayed neuronal death after brief forebrain ischemia in gerbils.

1 reference

12 December 2020

Proteases in Fas-mediated apoptosis

1 reference

12 December 2020

Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury

1 reference

12 December 2020

BCL-2 family members and the mitochondria in apoptosis

1 reference

12 December 2020

Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.

1 reference

12 December 2020

Mitochondria and programmed cell death: back to the future.

1 reference

12 December 2020

Transplantation of neural stem cells: cellular & gene therapy for hypoxic-ischemic brain injury

1 reference

12 December 2020

Mechanisms underlying hypoxia-induced neuronal apoptosis

1 reference

12 December 2020

Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs

1 reference

12 December 2020

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat.

1 reference

12 December 2020

A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). The RANTTAS Investigators

1 reference

12 December 2020

Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis.

1 reference

12 December 2020

Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage

1 reference

12 December 2020

Calcium movement in ischemia-tolerant hippocampal CA1 neurons after transient forebrain ischemia in gerbils.

1 reference

12 December 2020

Apoptosis induced by death receptors

1 reference

12 December 2020

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1 reference

12 December 2020

Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway.

1 reference

12 December 2020

Efficacy of antioxidant therapies in transient focal ischemia in mice

1 reference

12 December 2020

Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition

1 reference

12 December 2020

Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. GAIN International Investigators

1 reference

12 December 2020

Neurotrophins and brain insults.

1 reference

12 December 2020

Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

1 reference

12 December 2020

A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury

1 reference

12 December 2020

1 reference

12 December 2020

Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.

1 reference

12 December 2020

Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion.

1 reference

12 December 2020

Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions.

1 reference

12 December 2020

Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines

1 reference

12 December 2020

Changes in Extracellular Calcium Activity in Cerebral Ischaemia

1 reference

12 December 2020

Death receptors: signaling and modulation

1 reference

12 December 2020

Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia

1 reference

12 December 2020

Neurogenesis in adult mammals: some progress and problems.

1 reference

12 December 2020

The inhibitory mGluR agonist, S-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death

1 reference

12 December 2020

The Mechanism of Ion Translocation in Mitochondria. 4. Coupling of K+ Efflux with Ca2+ Uptake

1 reference

12 December 2020

Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke.

1 reference

12 December 2020

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1 reference

12 December 2020

TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal

1 reference

12 December 2020

Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing

1 reference

12 December 2020

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

1 reference

12 December 2020