(Q35099829)

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Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest

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Europe PubMed Central

PubMed publication ID

6 August 2017

Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest (English)

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Europe PubMed Central

PubMed publication ID

6 August 2017

7

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Éric A Cohen

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Europe PubMed Central

PubMed publication ID

6 August 2017

author name string

Francine C A Gérard

1

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Europe PubMed Central

PubMed publication ID

6 August 2017

Ruifeng Yang

2

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Europe PubMed Central

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6 August 2017

Bizhan Romani

3

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Europe PubMed Central

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6 August 2017

Alexis Poisson

4

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Europe PubMed Central

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6 August 2017

Jean-Philippe Belzile

5

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Europe PubMed Central

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6 August 2017

Nicole Rougeau

6

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6 August 2017

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publication date

18 February 2014

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Europe PubMed Central

PubMed publication ID

6 August 2017

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Europe PubMed Central

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6 August 2017

9

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Europe PubMed Central

PubMed publication ID

6 August 2017

2

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Europe PubMed Central

PubMed publication ID

6 August 2017

e89195

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Europe PubMed Central

PubMed publication ID

6 August 2017

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Creative Commons Attribution 4.0 International

18 February 2014

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3928422/fullTextXML

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The restriction factors of human immunodeficiency virus

1 reference

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CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

1 reference

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Intrinsic antiviral immunity

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The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover

1 reference

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Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response

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9 July 2018

The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.

1 reference

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Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome

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HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation

1 reference

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9 July 2018

Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest

1 reference

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Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

1 reference

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9 July 2018

HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest

1 reference

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A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery

1 reference

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CRL4s: the CUL4-RING E3 ubiquitin ligases

1 reference

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The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection

1 reference

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Suppression of Tetherin-restricting activity upon human immunodeficiency virus type 1 particle release correlates with localization of Vpu in the trans-Golgi network

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HIV-1 accessory proteins--ensuring viral survival in a hostile environment

1 reference

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9 July 2018

Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation.

1 reference

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9 July 2018

Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection

1 reference

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9 July 2018

VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation

1 reference

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9 July 2018

Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation

1 reference

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9 July 2018

HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase

1 reference

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9 July 2018

DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928422

9 July 2018

The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928422

9 July 2018

Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

1 reference

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DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

1 reference

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9 July 2018

HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system

1 reference

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HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928422

9 July 2018

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928422

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DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases

1 reference

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Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

1 reference

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Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.

1 reference

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Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo

1 reference

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Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases

1 reference

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Hepatitis B Virus X Protein and Simian Virus 5 V Protein Exhibit Similar UV-DDB1 Binding Properties To Mediate Distinct Activities

1 reference

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Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R.

1 reference

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Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP.

1 reference

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1 reference

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A novel Vpr peptide interactor fused to integrase (IN) restores integration activity to IN-defective HIV-1 virions

1 reference

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Vpr stimulates viral expression and induces cell killing in human immunodeficiency virus type 1-infected dividing Jurkat T cells

1 reference

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Diversity of HIV-1 Vpr interactions involves usage of the WXXF motif of host cell proteins

1 reference

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27 September 2018

Identifiers

10.1371/JOURNAL.PONE.0089195

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Europe PubMed Central

PubMed publication ID

6 August 2017

2014PLoSO...989195G

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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