(Q35136214)

English

Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: experimental clarifications and persistent clinical questions

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

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Europe PubMed Central

Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: experimental clarifications and persistent clinical questions (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

author name string

William Lewis

1

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Europe PubMed Central

PubMed publication ID

6 August 2017

publication date

1 May 2003

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Antiviral Research

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

58

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

189-197

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Oxidants, antioxidants, and the degenerative diseases of aging

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Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

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2',3'-dideoxycytidine (ddC) toxic neuropathy: a study of 52 patients

1 reference

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Chick-Embryo DNA Polymerase gamma. Identity of gamma-Polymerases Purified from Nuclei and Mitochondria

1 reference

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7 January 2021

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What is oxidative stress?

1 reference

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DNA strand scission by enzymically generated oxygen radicals

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Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy

1 reference

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Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway

1 reference

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Treatment of nucleoside reverse transcriptase inhibitor-induced lactic acidosis

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The accessory subunit of Xenopus laevis mitochondrial DNA polymerase gamma increases processivity of the catalytic subunit of human DNA polymerase gamma and is related to class II aminoacyl-tRNA synthetases

1 reference

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inferred from DOI database lookup

Mitochondrial DNA and nucleoside toxicity

1 reference

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7 January 2021

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Partial cytochrome c oxidase deficiency and cytoplasmic bodies in patients with zidovudine myopathy

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Determination of the blood lactate:pyruvate ratio as a noninvasive test for the diagnosis of zidovudine myopathy.

1 reference

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Lactic acidosis complicating the acquired immunodeficiency syndrome

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Once-daily administration of 2',3'-dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. Results of a Phase I trial

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Degeneration of human oncogenes and mitochondrial genes occurs in cells that exhibit age-related pathology

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Peripheral neuropathy and antiretroviral drugs

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7 January 2021

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Mitochondrial myopathy caused by long-term zidovudine therapy

1 reference

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Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage

1 reference

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7 January 2021

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Mitochondrial alterations with mitochondrial DNA depletion in the nerves of AIDS patients with peripheral neuropathy induced by 2'3'-dideoxycytidine (ddC).

1 reference

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7 January 2021

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Dilated cardiomyopathy in a zidovudine-treated AIDS patient

1 reference

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7 January 2021

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AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins

1 reference

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7 January 2021

based on heuristic

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Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver

1 reference

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7 January 2021

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Effect of zidovudine and didanosine treatment on heart function in children infected with human immunodeficiency virus

1 reference

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7 January 2021

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Free radicals in the physiological control of cell function

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7 January 2021

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inferred from DOI database lookup

Oxidant-antioxidant status in human immunodeficiency virus infection

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7 January 2021

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Functions of glutathione and glutathione disulfide in immunology and immunopathology.

1 reference

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7 January 2021

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Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2',3'-dideoxycytidine (ddC).

1 reference

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7 January 2021

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Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase

1 reference

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7 January 2021

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Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs

1 reference

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7 January 2021

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Is cell aging caused by respiration-dependent injury to the mitochondrial genome?

1 reference

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7 January 2021

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Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks

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Hepatomegaly with severe steatosis in HIV-seropositive patients

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Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine

1 reference

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Fetal patas monkeys sustain mitochondrial toxicity as a result of in utero zidovudine exposure

1 reference

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Mutagenesis by 8-oxoguanine: an enemy within

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Zidovudine intolerance.

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Cellular and molecular mechanisms of endothelial cell dysfunction

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Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia

1 reference

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Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

1 reference

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Cardiomyopathy Associated with Antiretroviral Therapy in Patients with HIV Infection: A Report of Six Cases

1 reference

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Mitochondrial injury. Lessons from the fialuridine trial

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Reye's syndrome in adult with AIDS

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity as an etiology for lipodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Is the failing heart energy depleted?

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1 reference

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based on heuristic

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2',3'-dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. A phase I trial

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Combination Antiretroviral Therapy

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiomyopathy in AIDS: a pathophysiological perspective

1 reference

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7 January 2021

based on heuristic

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Mitochondrial DNA replication, nucleoside reverse-transcriptase inhibitors, and AIDS cardiomyopathy

1 reference

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based on heuristic

inferred from DOI database lookup

Defective mitochondrial DNA replication and NRTIs: pathophysiological implications in AIDS cardiomyopathy

1 reference

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based on heuristic

inferred from DOI database lookup

Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial toxicity of antiviral drugs

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Absence of Cardiac Toxicity of Zidovudine in Infants

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac structure and function in children with human immunodeficiency virus infection treated with zidovudine

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The development of mitochondrial medicine

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

AZT decreases rat myocardial cytochrome oxidase activity and increases beta-myosin heavy chain content

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficiency virus (HIV) infections. A phase I and II study

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA biosynthesis in mitochondria: partial purification of a distinct DNA polymerase from isolated rat liver mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

AZT causes tissue-specific inhibition of mitochondrial bioenergetic function

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA replication fidelity with 8-oxodeoxyguanosine triphosphate.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Ultrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient repair of abasic sites in DNA by mitochondrial enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Do mitochondrial DNA fragments promote cancer and aging?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial DNA diseases: histological and cellular studies

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Base modification and strand breakage in isolated calf thymus DNA and in DNA from human skin epidermal keratinocytes exposed to peroxynitrite or 3-morpholinosydnonimine

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial toxicity--new adverse drug effects

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Myopathy with human immunodeficiency virus type 1 (HIV-1) infection: HIV-1 or zidovudine?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Diseases of the mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial diseases in man and mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The expanding spectrum of nuclear gene mutations in mitochondrial disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900069-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0166-3542(03)00069-X

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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