(Q35140832)

6 August 2017

1 reference

title

Genetic strategies for antibacterial drug discovery (English)

1 reference

6 August 2017

1 reference

Lynn Miesel

1

1 reference

PubMed ID

12776214

6 August 2017

Jonathan Greene

series ordinal

2

1 reference

PubMed ID

12776214

6 August 2017

Todd A Black

series ordinal

3

1 reference

6 August 2017

1 June 2003

1 reference

6 August 2017

Nature Reviews Genetics

1 reference

6 August 2017

4

1 reference

6 August 2017

442-456

1 reference

6 August 2017

6

1 reference

https://scigraph.springernature.com/pub.10.1038/nrg1086

6 August 2017

0 references

cites work

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd

1 reference

Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.

31 March 2020

1 reference

The complete genome sequence of Escherichia coli K-12

31 March 2020

1 reference

The complete genome sequence of the gram-positive bacterium Bacillus subtilis

31 March 2020

1 reference

31 March 2020

1 reference

31 March 2020

1 reference

31 March 2020

1 reference

Inactivation of antibiotics and the dissemination of resistance genes

31 March 2020

1 reference

Molecular mechanisms that confer antibacterial drug resistance

31 March 2020

1 reference

Discovery and development of new antimicrobial agents

31 March 2020

1 reference

Exploiting genomics to discover new antibiotics

31 March 2020

1 reference

N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity

31 March 2020

1 reference

Discovery of a novel and potent class of FabI-directed antibacterial agents

31 March 2020

1 reference

31 March 2020

1 reference

Recognition of genes in DNA sequence with ambiguities.

31 March 2020

1 reference

Prediction of complete gene structures in human genomic DNA

31 March 2020

1 reference

Automated gene identification in large-scale genomic sequences.

31 March 2020

1 reference

Improved microbial gene identification with GLIMMER

31 March 2020

1 reference

Database resources of the National Center for Biotechnology

31 March 2020

1 reference

EcoGene: a genome sequence database for Escherichia coli K-12.

31 March 2020

1 reference

SubtiList: the reference database for the Bacillus subtilis genome

31 March 2020

1 reference

Learning from the genome sequence of Mycobacterium tuberculosis H37Rv

31 March 2020

1 reference

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

31 March 2020

1 reference

The COG database: new developments in phylogenetic classification of proteins from complete genomes

31 March 2020

1 reference

Structural proteomics: the potential of high-throughput structure determination.

31 March 2020

1 reference

Comparative protein structure modeling of genes and genomes

31 March 2020

1 reference

High-throughput crystallography at an affordable cost: the TB Structural Genomics Consortium Crystallization Facility

31 March 2020

1 reference

A minimal gene set for cellular life derived by comparison of complete bacterial genomes

31 March 2020

1 reference

How many genes can make a cell: the minimal-gene-set concept

31 March 2020

1 reference

Global transposon mutagenesis and a minimal Mycoplasma genome

31 March 2020

1 reference

A genome-based approach for the identification of essential bacterial genes.

31 March 2020

1 reference

From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways

31 March 2020

1 reference

rho is not essential for viability or virulence in Staphylococcus aureus

31 March 2020

1 reference

Bex, the Bacillus subtilis homolog of the essential Escherichia coli GTPase Era, is required for normal cell division and spore formation

31 March 2020

1 reference

Erratum: A triclosan-resistant bacterial enzyme

31 March 2020

1 reference

Rational identification of new antibacterial drug targets that are essential for viability using a genomics-based approach

31 March 2020

1 reference

Genetic footprinting in bacteria

31 March 2020

1 reference

Systematic identification of essential genes by in vitro mariner mutagenesis

31 March 2020

1 reference

Selection analyses of insertional mutants using subgenic-resolution arrays

31 March 2020

1 reference

Comprehensive identification of conditionally essential genes in mycobacteria

31 March 2020

1 reference

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae

31 March 2020

1 reference

Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa

31 March 2020

1 reference

A vector for systematic gene inactivation in Bacillus subtilis

31 March 2020

1 reference

Essential Bacillus subtilis genes

31 March 2020

1 reference

Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae

31 March 2020

1 reference

Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons

31 March 2020

1 reference

Anti-mRNA: specific inhibition of translation of single mRNA molecules

31 March 2020

1 reference

Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties

31 March 2020

1 reference

Conditional expression of Mycobacterium smegmatis dnaA, an essential DNA replication gene

31 March 2020

1 reference

Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA.

31 March 2020

1 reference

A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

31 March 2020

1 reference

Consequences of RNase E scarcity in Escherichia coli.

31 March 2020

1 reference

Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

31 March 2020

1 reference

Tn5tac1, a derivative of transposon Tn5 that generates conditional mutations

31 March 2020

1 reference

A Tn10 derivative (T-POP) for isolation of insertions with conditional (tetracycline-dependent) phenotypes

31 March 2020

1 reference

Analysis of Pseudomonas gene products using lacIq/Ptrp-lac plasmids and transposons that confer conditional phenotypes

31 March 2020

1 reference

Regulated expression of heterologous genes in Bacillus subtilis using the Tn10 encoded tet regulatory elements

31 March 2020

1 reference

Two essential DNA polymerases at the bacterial replication fork.

31 March 2020

1 reference

Regulated ectopic expression and allelic-replacement mutagenesis as a method for gene essentiality testing in Staphylococcus aureus

31 March 2020

1 reference

A method for demonstrating gene essentiality in Staphylococcus aureus.

31 March 2020

1 reference

Integrational plasmids for the tetracycline-regulated expression of genes in Streptococcus pneumoniae

31 March 2020

1 reference

Characterization of a novel fucose-regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae

31 March 2020

1 reference

TnAraOut, a transposon-based approach to identify and characterize essential bacterial genes

31 March 2020

1 reference

A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants

31 March 2020

1 reference

Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization

31 March 2020

1 reference

A new mutation delivery system for genome-scale approaches in Bacillus subtilis

31 March 2020

1 reference

PCR ligation mutagenesis in transformable streptococci: application and efficiency.

31 March 2020

1 reference

Rapid method for the identification of essential genes in Staphylococcus aureus

31 March 2020

1 reference

Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis

31 March 2020

1 reference

Integration-proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strains

31 March 2020

1 reference

Conditional-replication, integration, excision, and retrieval plasmid-host systems for gene structure-function studies of bacteria

31 March 2020

1 reference

Plasmids for ectopic integration in Bacillus subtilis.

31 March 2020

1 reference

Genetic methods for deciphering virulence determinants of Mycobacterium tuberculosis

31 March 2020

1 reference

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

31 March 2020

1 reference

DNA ligase: structure, mechanism, and function

31 March 2020

1 reference

Characterization of the yaeL gene product and its S2P-protease motifs in Escherichia coli

31 March 2020

1 reference

Characterization of the depletion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase in Escherichia coli and Bacillus subtilis

31 March 2020

1 reference

In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance

31 March 2020

1 reference

Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis

31 March 2020

1 reference

Deficiency of essential GTP-binding protein ObgE in Escherichia coli inhibits chromosome partition

31 March 2020

1 reference

The FtsQ protein of Escherichia coli: membrane topology, abundance, and cell division phenotypes due to overproduction and insertion mutations

31 March 2020

1 reference

envM genes of Salmonella typhimurium and Escherichia coli

31 March 2020

1 reference

Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-negative bacteria

31 March 2020

1 reference

Conditional mutations affecting the cell envelope ofEscherichia coliK-12

31 March 2020

1 reference

Phenotype microarrays for high-throughput phenotypic testing and assay of gene function

31 March 2020

1 reference

A double counter-selection system for the study of null alleles of essential genes in Escherichia coli

31 March 2020

1 reference

DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response

31 March 2020

1 reference

Peptide deformylase as an antibacterial drug target: target validation and resistance development

31 March 2020

1 reference

Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene

31 March 2020

1 reference

Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase

31 March 2020

1 reference

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

31 March 2020

1 reference

Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action

31 March 2020

1 reference

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor

31 March 2020

1 reference

An array of target-specific screening strains for antibacterial discovery

31 March 2020

1 reference

Mechanism of triclosan inhibition of bacterial fatty acid synthesis

31 March 2020

1 reference

Comprehensive essential gene identification as a platform for novel anti-infective drug discovery.

31 March 2020

1 reference

Recombinant microorganisms as environmental biosensors: pollutants detection by Escherichia coli bearing fabA'::lux fusions

31 March 2020

1 reference

Structural gene for NAD synthetase in Salmonella typhimurium

31 March 2020

1 reference

A pathway-specific cell based screening system to detect bacterial cell wall inhibitors.

31 March 2020

1 reference

Role of the murein precursor UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala in repression of beta-lactamase induction in cell division mutants

31 March 2020

1 reference

Identification of compounds that inhibit late steps of peptidoglycan synthesis in bacteria.

31 March 2020

1 reference

Antibiotics that inhibit cell wall biosynthesis induce expression of the Bacillus subtilis sigma(W) and sigma(M) regulons

31 March 2020

1 reference

A genomic approach to gene fusion technology

31 March 2020

1 reference

Impact of genomic technologies on studies of bacterial gene expression

31 March 2020

1 reference

Harnessing the power of the genome in the search for new antibiotics

31 March 2020

1 reference

Cluster analysis and display of genome-wide expression patterns

31 March 2020

1 reference

Drug target validation and identification of secondary drug target effects using DNA microarrays

31 March 2020

1 reference

Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors

31 March 2020

1 reference

Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis

31 March 2020

1 reference

Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization

31 March 2020

1 reference

PCR-based ordered genomic libraries: a new approach to drug target identification for Streptococcus pneumoniae

31 March 2020

1 reference

Antimicrobials: new solutions badly needed

31 March 2020

1 reference

The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors

31 March 2020

1 reference

Linezolid: the first oxazolidinone antimicrobial

31 March 2020

1 reference

Active efflux, a common mechanism for biocide and antibiotic resistance

31 March 2020

1 reference

Mechanism of action of and resistance to quinolones

31 March 2020

1 reference

Linezolid resistance in clinical isolates of Staphylococcus aureus

31 March 2020

1 reference

Genomics in anti-infective drug discovery--getting to endgame

31 March 2020

1 reference

New (and not so new) antibacterial targets - from where and when will the novel drugs come?

31 March 2020

1 reference

Deformylase as a novel antibacterial target.

31 March 2020

1 reference

Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

31 March 2020

1 reference

Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.

31 March 2020

1 reference

Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics

31 March 2020

1 reference

Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery

31 March 2020

1 reference

Triclosan targets lipid synthesis

31 March 2020

1 reference

Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis

31 March 2020

1 reference

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

31 March 2020

1 reference

The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis

31 March 2020

1 reference

Whole genome sequencing of meticillin-resistant Staphylococcus aureus

31 March 2020

1 reference

Complete genome sequence of an M1 strain of Streptococcus pyogenes

31 March 2020

1 reference

Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae

31 March 2020

1 reference

Role of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalis

31 March 2020

1 reference

Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae

31 March 2020

1 reference

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

31 March 2020

1 reference

The complete genome sequence of the gastric pathogen Helicobacter pylori

31 March 2020

1 reference

Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18

31 March 2020

1 reference

Complete genome sequence of Salmonella enterica serovar Typhimurium LT2

31 March 2020

1 reference

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

31 March 2020

1 reference

Methionine in and out of proteins: targets for drug design

31 March 2020

1 reference

Comparison of the construction of unmarked deletion mutations in Mycobacterium smegmatis, Mycobacterium bovis bacillus Calmette-Guérin, and Mycobacterium tuberculosis H37Rv by allelic exchange.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Antimicrobial actions of hexachlorophene: release of cytoplasmic materials.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRG1086

1 reference

6 August 2017

1 reference

PubMed ID

12776214