(Q35144310)

6 August 2017

title

N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons (English)

1 reference

6 August 2017

0 references

1 reference

Chia-Yu Chang

1

1 reference

6 August 2017

Sheng-Mei Chen

2

1 reference

6 August 2017

Huai-En Lu

3

1 reference

6 August 2017

Syu-Ming Lai

4

1 reference

6 August 2017

Ping-Shan Lai

5

1 reference

6 August 2017

Po-Wen Shen

6

1 reference

6 August 2017

Pei-Ying Chen

7

1 reference

6 August 2017

Ching-I Shen

8

1 reference

6 August 2017

Horng-Jyh Harn

9

1 reference

6 August 2017

Shinn-Zong Lin

10

1 reference

6 August 2017

Shiaw-Min Hwang

11

1 reference

6 August 2017

Hong-Lin Su

12

1 reference

6 August 2017

language of work or name

English

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publication date

4 March 2015

1 reference

full work available at URL

6 August 2017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348654

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published in

Scientific Reports

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6 August 2017

volume

5

1 reference

6 August 2017

page(s)

8744

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Creative Commons Attribution 4.0 International

6 August 2017

copyright license

start time

4 March 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease

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Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

13 July 2018

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Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease

13 July 2018

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Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson's disease

13 July 2018

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

13 July 2018

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l-3-n-Butylphthalide regulates amyloid precursor protein processing by PKC and MAPK pathways in SK-N-SH cells over-expressing wild type human APP695

13 July 2018

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Expression of Nur77 induced by an n-butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma

13 July 2018

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L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease

13 July 2018

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Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

13 July 2018

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n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2alpha and telomerase activity

13 July 2018

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Down syndrome--recent progress and future prospects

13 July 2018

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Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

13 July 2018

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Blastocoel volume is related to successful establishment of human embryonic stem cell lines

13 July 2018

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Disease-specific induced pluripotent stem cells

13 July 2018

1 reference

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Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

The GSK3 hypothesis of Alzheimer's disease

13 July 2018

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

13 July 2018

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

13 July 2018

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The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo

13 July 2018

1 reference

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Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs

13 July 2018

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

13 July 2018

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The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

13 July 2018

1 reference

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Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Amyloid beta-protein and the genetics of Alzheimer's disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

The neurobiologic consequences of Down syndrome

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

L-3-n-butylphthalide improves cognitive impairment of APP/PS1 mice by BDNF/TrkB/PI3K/AKT pathway

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Prerequisite OCT4 Maintenance Potentiates the Neural Induction of Differentiating Human Embryonic Stem Cells and Induced Pluripotent Stem Cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Modeling neurogenesis impairment in Down syndrome with induced pluripotent stem cells from Trisomy 21 amniotic fluid cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

GSK3beta activity modifies the localization and function of presenilin 1.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348654

Pluronic F-127 gels as a vehicle for topical administration of anticancer agents

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25735452

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP08744

1 reference

6 August 2017

1 reference

6 August 2017

1 reference