(Q35144851)

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Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction.

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4 February 2020

Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction (English)

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4 February 2020

Alfredo Miñano-Molina

1

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4 February 2020

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4 February 2020

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4 February 2020

Carlos A. Saura

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4 February 2020

José Rodríguez-Alvarez

9

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4 February 2020

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Judit España

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4 February 2020

Elsa Martín

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4 February 2020

Bruna Barneda-Zahonero

4

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4 February 2020

Rut Fadó

5

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4 February 2020

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10 June 2011

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4 February 2020

Journal of Biological Chemistry

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4 February 2020

286

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4 February 2020

31

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4 February 2020

27311-27321

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4 February 2020

describes a project that uses

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11 June 2022

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Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers

1 reference

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Calcium signaling and amyloid toxicity in Alzheimer disease

1 reference

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13 July 2018

Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus

1 reference

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13 July 2018

Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation

1 reference

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13 July 2018

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

1 reference

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13 July 2018

Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways

1 reference

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13 July 2018

Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach

1 reference

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13 July 2018

Delivery of AMPA receptors to perisynaptic sites precedes the full expression of long-term potentiation

1 reference

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13 July 2018

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

1 reference

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13 July 2018

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

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13 July 2018

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization

1 reference

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13 July 2018

Amyloid beta peptides and glutamatergic synaptic dysregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Long-term synaptic plasticity in hippocampal interneurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

The cell biology of synaptic plasticity: AMPA receptor trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Regulation of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Receptor trafficking and synaptic plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

1 reference

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13 July 2018

Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent.

1 reference

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13 July 2018

AMPA Receptor Trafficking at Excitatory Synapses

1 reference

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13 July 2018

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

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13 July 2018

APP processing and synaptic function

1 reference

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13 July 2018

Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory

1 reference

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13 July 2018

PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Alzheimer's disease is a synaptic failure

1 reference

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13 July 2018

Regulation of AMPA receptors during synaptic plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

1 reference

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13 July 2018

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Long-term depression: a cascade of induction and expression mechanisms.

1 reference

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13 July 2018

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 reference

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13 July 2018

Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting

1 reference

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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

1 reference

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13 July 2018

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

LTP mechanisms: from silence to four-lane traffic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

13 July 2018

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

Amyloid-beta decreases cell-surface AMPA receptors by increasing intracellular calcium and phosphorylation of GluR2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

beta-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

Divergent effects of Abeta1-42 on ionotropic glutamate receptor-mediated responses in CA1 neurons in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.227504

21 January 2018

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

27 September 2018

beta-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149325

27 September 2018

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

https://pubmed.ncbi.nlm.nih.gov/21665950

12 December 2020

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Identifiers

10.1074/JBC.M111.227504

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21665950%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21665950%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21665950%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

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