(Q35161465)

6 August 2017

title

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease (English)

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6 August 2017

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Kou Takahashi

1

1 reference

6 August 2017

Qiongman Kong

2

1 reference

6 August 2017

Yuchen Lin

3

1 reference

6 August 2017

Nathan Stouffer

4

1 reference

6 August 2017

Delanie A Schulte

5

1 reference

6 August 2017

Liching Lai

6

1 reference

6 August 2017

Qibing Liu

7

1 reference

6 August 2017

Ling-Chu Chang

8

1 reference

6 August 2017

Sky Dominguez

9

1 reference

6 August 2017

Xuechao Xing

10

1 reference

6 August 2017

Gregory D Cuny

11

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6 August 2017

Kevin J Hodgetts

12

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6 August 2017

Marcie A Glicksman

13

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6 August 2017

Chien-Liang Glenn Lin

14

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6 August 2017

language of work or name

English

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publication date

23 February 2015

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Journal of Experimental Medicine

6 August 2017

published in

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6 August 2017

volume

212

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6 August 2017

issue

3

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6 August 2017

page(s)

319-332

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describes a project that uses

6 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4354363/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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13 July 2018

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13 July 2018

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Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

13 July 2018

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13 July 2018

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Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus

13 July 2018

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13 July 2018

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13 July 2018

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Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex

13 July 2018

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Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

13 July 2018

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GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model

13 July 2018

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Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

13 July 2018

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Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory

13 July 2018

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Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity

13 July 2018

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Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease.

13 July 2018

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Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals

13 July 2018

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Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease

13 July 2018

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Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

13 July 2018

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Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport

13 July 2018

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Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

13 July 2018

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13 July 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

13 July 2018

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Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

13 July 2018

1 reference

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NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

13 July 2018

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Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals.

13 July 2018

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13 July 2018

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

13 July 2018

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13 July 2018

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Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus.

13 July 2018

1 reference

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Hippocampal glutamate transporter 1 (GLT-1) complex levels are paralleling memory training in the Multiple T-maze in C57BL/6J mice.

27 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Amyloid beta protein modulates glutamate-mediated neurotransmission in the rat basal forebrain: involvement of presynaptic neuronal nicotinic acetylcholine and metabotropic glutamate receptors.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Evolution of neuronal changes in the course of Alzheimer's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354363

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25711212

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25711212

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20140413

1 reference

6 August 2017

1 reference

6 August 2017

1 reference