(Q42792570)

English

Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

scientific article published on November 2010

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Karim Bordji

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Javier Becerril-Ortega

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

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publication date

1 November 2010

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Europe PubMed Central

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17 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

30

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

47

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

15927-15942

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A systemic administration of NMDA induces immediate early gene pip92 in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mobile NMDA receptors at hippocampal synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Yin and Yang of NMDA receptor signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing and synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein mRNA levels in Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta precursor protein processing in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A consensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intronic binding sites for hnRNP A/B and hnRNP F/H proteins stimulate pre-mRNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro galantamine-memantine co-application: mechanism of beneficial action

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exon silencing by UAGG motifs in response to neuronal excitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for SC35 and hnRNPA1 in the determination of amyloid precursor protein isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compartmentalized NMDA receptor signalling to survival and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tex261 modulates the excitotoxic cell death induced by N-methyl-D-aspartate (NMDA) receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathologically activated therapeutics for neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal regulation of alternative pre-mRNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid flirting with synaptic failure: towards a comprehensive view of Alzheimer's disease pathogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

hnRNP proteins and splicing control.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linking calcium to Abeta and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calmodulin-kinases: modulators of neuronal development and plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential APP gene expression in rat cerebral cortex, meninges, and primary astroglial, microglial and neuronal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothesis on the regulation of cytosol calcium concentration and the aging brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new generation of Ca2+ indicators with greatly improved fluorescence properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic NMDA receptor channels have a low open probability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protease nexin-2/amyloid beta-protein precursor inhibits factor Xa in the prothrombinase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid precursor protein (APP) and APP-RNA are rapidly affected by glutamate in cultured neurons: selective increase of mRNAs encoding a Kunitz protease inhibitor domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbamoylation of brain glutamate receptors by a disulfiram metabolite

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-ischemic changes in the expression of Alzheimer's APP isoforms in rat cerebral cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106831

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3021-10.2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106831%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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