(Q35170428)

6 August 2017

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title

Role of tissue stroma in cancer cell invasion (English)

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6 August 2017

Olivier De Wever

1

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PubMed ID

12845611

6 August 2017

Marc Mareel

series ordinal

2

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6 August 2017

1 July 2003

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6 August 2017

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6 August 2017

200

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6 August 2017

429-447

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6 August 2017

4

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Molecular themes in oncogenesis

6 August 2017

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Clinical, cellular, and molecular aspects of cancer invasion

21 January 2018

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Induction of invasion in vivo of alpha-catenin-positive HCT-8 human colon-cancer cells

21 January 2018

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Single alteration of p53 or E-cadherin genes can alter the surgical resection benefit in an experimental model of colon cancer

21 January 2018

1 reference

Evidence that metastasis is less common in cirrhotic than normal liver: a systematic review of post-mortem case-control studies.

21 January 2018

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Metastasis to bone: causes, consequences and therapeutic opportunities

21 January 2018

1 reference

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways

21 January 2018

1 reference

Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways

21 January 2018

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The distribution of secondary growths in cancer of the breast. 1889

21 January 2018

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The microenvironment of the tumour-host interface

21 January 2018

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In vivo and in vitro invasiveness of a rat colon-cancer cell line maintaining E-cadherin expression: an enhancing role of tumor-associated myofibroblasts

21 January 2018

1 reference

Epithelial-mesenchymal transitions in tumour progression

21 January 2018

1 reference

Human fetal enterocytes in vitro: modulation of the phenotype by extracellular matrix

21 January 2018

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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

21 January 2018

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Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-beta

21 January 2018

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Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

21 January 2018

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Angiogenesis in cancer and other diseases

21 January 2018

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Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma

21 January 2018

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Angiogenesis in cancer, vascular, rheumatoid and other disease

21 January 2018

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Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta

21 January 2018

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TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

21 January 2018

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Human breast carcinoma desmoplasia is PDGF initiated.

21 January 2018

1 reference

Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing

21 January 2018

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Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway

21 January 2018

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Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues

21 January 2018

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The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure

21 January 2018

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Myofibroblasts differentiate from fibroblasts when plated at low density

21 January 2018

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Transforming growth factor beta 1 and interleukin 4 induced alpha smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor

21 January 2018

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Effects of pentoxifylline, pentifylline and gamma-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts

21 January 2018

1 reference

Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells

21 January 2018

1 reference

TGF-beta signaling in tumor suppression and cancer progression

21 January 2018

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Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology

21 January 2018

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Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin

21 January 2018

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The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

21 January 2018

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

21 January 2018

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Thrombospondin-1 is a major activator of TGF-beta1 in vivo

21 January 2018

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Role of myofibroblasts at the invasion front

21 January 2018

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Genetic events and the role of TGF beta in epithelial tumour progression

21 January 2018

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TGFbeta signaling in growth control, cancer, and heritable disorders

21 January 2018

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TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

21 January 2018

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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

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Vascular growth factors and lymphangiogenesis

21 January 2018

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Lymphatic dissemination of tumour cells and the formation of micrometastases

21 January 2018

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Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

21 January 2018

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

21 January 2018

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Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.

21 January 2018

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Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells

21 January 2018

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Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue

21 January 2018

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Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts

21 January 2018

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The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells

21 January 2018

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Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor

21 January 2018

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What might a stromal response mean to prostate cancer progression?

21 January 2018

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Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion

21 January 2018

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Discovery of novel tumor markers of pancreatic cancer using global gene expression technology

21 January 2018

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Role of stromal myofibroblasts infiltrating colon cancer in tumor invasion

21 January 2018

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In fibroblasts Vegf-D expression is induced by cell-cell contact mediated by cadherin-11.

21 January 2018

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Beta-catenin: a key mediator of Wnt signaling

21 January 2018

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Functional interaction of beta-catenin with the transcription factor LEF-1

21 January 2018

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Beta-catenin and the morphogenesis of colorectal cancer

21 January 2018

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Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

21 January 2018

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Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways

21 January 2018

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Interaction between the transforming growth factor-beta type II receptor/Smad pathway and beta-catenin during transforming growth factor-beta1-mediated adherens junction disassembly

21 January 2018

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Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway

21 January 2018

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Effects of transforming growth factor-beta1 and tumour necrosis factor-alpha on cultured fibroblasts from skin fibroma as modulated by toremifene.

21 January 2018

1 reference

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

21 January 2018

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Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

21 January 2018

1 reference

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

21 January 2018

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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

21 January 2018

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Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis

21 January 2018

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TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

21 January 2018

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 January 2018

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Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression

21 January 2018

1 reference

Cyclosporine induces cancer progression by a cell-autonomous mechanism.

21 January 2018

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Marrow stromal cells as stem cells for nonhematopoietic tissues

21 January 2018

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Differential expression of CD34 in normal colorectal tissue, peritumoral inflammatory tissue, and tumour stroma

21 January 2018

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Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo

21 January 2018

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21 January 2018

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

21 January 2018

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Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro

21 January 2018

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Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis

21 January 2018

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Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation

21 January 2018

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Identification and characterization of a fibroblast marker: FSP1

21 January 2018

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Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-beta1-dependent mechanism in vitro.

21 January 2018

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Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)

21 January 2018

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The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion.

21 January 2018

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Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

21 January 2018

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ECM signalling: orchestrating cell behaviour and misbehaviour.

21 January 2018

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Molecular mechanisms of cancer pain

21 January 2018

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Mammalian RGS proteins: barbarians at the gate

21 January 2018

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The many faces of G protein signaling

21 January 2018

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G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells

21 January 2018

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Colorectal cancer—prognostic signs in “local disease”

21 January 2018

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Defective E-cadherin/catenin complexes in human cancer

21 January 2018

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Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion

21 January 2018

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Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

21 January 2018

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E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells

21 January 2018

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Plasmin produces an E-cadherin fragment that stimulates cancer cell invasion

21 January 2018

1 reference

Purification and characterization of NCAD90, a soluble endogenous form of N-cadherin, which is generated by proteolysis during retinal development and retains adhesive and neurite-promoting function.

21 January 2018

1 reference

Soluble N-cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N-cadherin and the fibroblast growth factor receptor co-cluster in cells

21 January 2018

1 reference

Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model

21 January 2018

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MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function

21 January 2018

1 reference

CAM-FGF receptor interactions: a model for axonal growth

21 January 2018

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N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression

21 January 2018

1 reference

Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

21 January 2018

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

21 January 2018

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Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis

21 January 2018

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FGFs, heparan sulfate and FGFRs: complex interactions essential for development

21 January 2018

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Structural basis for FGF receptor dimerization and activation

21 January 2018

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Structural basis of cell-cell adhesion by cadherins

21 January 2018

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N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility

21 January 2018

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Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo.

21 January 2018

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Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization

21 January 2018

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Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion

21 January 2018

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Involvement of the tyrosine kinase fer in cell adhesion

21 January 2018

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N-cadherin-mediated adhesion and aberrant catenin expression in anaplastic thyroid-carcinoma cell lines.

21 January 2018

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N-Cadherin expression in human prostate carcinoma cell lines. An epithelial-mesenchymal transformation mediating adhesion withStromal cells.

21 January 2018

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Regulation of Rho GTPases by p120-catenin

21 January 2018

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Inhibition of RhoA by p120 catenin

21 January 2018

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p120 catenin regulates the actin cytoskeleton via Rho family GTPases

21 January 2018

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Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes

21 January 2018

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Identification of Src phosphorylation sites in the catenin p120ctn

21 January 2018

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The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin

21 January 2018

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Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)

21 January 2018

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The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)

21 January 2018

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PTPmu regulates N-cadherin-dependent neurite outgrowth

21 January 2018

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The nonreceptor tyrosine kinase fer mediates cross-talk between N-cadherin and beta1-integrins

21 January 2018

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The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage

21 January 2018

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Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin

21 January 2018

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PTP1B modulates the association of beta-catenin with N-cadherin through binding to an adjacent and partially overlapping target site

21 January 2018

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Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.

21 January 2018

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Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization

21 January 2018

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The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness

21 January 2018

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Invasion of retinal pigment epithelial cells: N-cadherin, hepatocyte growth factor, and focal adhesion kinase

21 January 2018

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HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers

21 January 2018

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Mutations in the SMAD4/DPC4 gene in juvenile polyposis

21 January 2018

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A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria.

21 January 2018

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Transforming growth factor-beta activation in irradiated murine mammary gland

21 January 2018

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Cancer: stuck at first base.

21 January 2018

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Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

21 January 2018

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Effect of p53 status on tumor response to antiangiogenic therapy.

21 January 2018

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Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

21 January 2018

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Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

21 January 2018

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Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

21 January 2018

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Gene therapy by transforming growth factor-beta receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis.

21 January 2018

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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

21 January 2018

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Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

21 January 2018

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IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis

21 January 2018

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Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation

21 January 2018

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Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

21 January 2018

1 reference

Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts.

21 January 2018

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Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries.

21 January 2018

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Pentoxifylline reduces in vitro renal myofibroblast proliferation and collagen secretion

21 January 2018

1 reference

Proximal tubular cells promote fibrogenesis by TGF-beta1-mediated induction of peritubular myofibroblasts

21 January 2018

1 reference

PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis

21 January 2018

1 reference

New functions for the matrix metalloproteinases in cancer progression

21 January 2018

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Apigenin decreases expression of the myofibroblast phenotype

21 January 2018

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Novel anti-inflammatory effects of the inhaled corticosteroid fluticasone propionate during lung myofibroblastic differentiation.

21 January 2018

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Deactivation of cultured human liver myofibroblasts by trans-resveratrol, a grapevine-derived polyphenol

21 January 2018

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The compliance of collagen gels regulates transforming growth factor-beta induction of alpha-smooth muscle actin in fibroblasts

21 January 2018

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Mechanisms of myofibroblast activity and phenotypic modulation.

21 January 2018

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A reevaluation of integrins as regulators of angiogenesis

21 January 2018

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Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions

21 January 2018

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Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion

21 January 2018

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A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif

21 January 2018

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Chemotactic factors, passive invasion and metastasis of cancer cells

21 January 2018

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ONCOGENESIS: Landscaping the Cancer Terrain

21 January 2018

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21 January 2018

An anchor for activation

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Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.1398

1 reference

6 August 2017

1 reference

PubMed ID

12845611