(Q35177419)

6 August 2017

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title

Viewpoint: therapeutic implications of CTLA-4 compartmentalization (English)

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6 August 2017

Miren L Baroja

1

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6 August 2017

Joaquín Madrenas

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

1 August 2003

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American Journal of Transplantation

6 August 2017

published in

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6 August 2017

volume

3

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6 August 2017

issue

8

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6 August 2017

page(s)

919-926

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Structural mechanisms of costimulation

6 August 2017

cites work

1 reference

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The immunological synapse: a molecular machine controlling T cell activation

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Negative co-receptors on lymphocytes

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Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

21 January 2018

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Structure of murine CTLA-4 and its role in modulating T cell responsiveness

21 January 2018

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Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

21 January 2018

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Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

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Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail

21 January 2018

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Structural analysis of CTLA-4 function in vivo

21 January 2018

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Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

21 January 2018

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Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules

21 January 2018

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Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin

21 January 2018

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The immunological synapse.

21 January 2018

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T cell receptor signaling precedes immunological synapse formation

21 January 2018

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In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.

21 January 2018

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Neural and immunological synaptic relations

21 January 2018

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Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation.

21 January 2018

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The amplification of TCR signaling by dynamic membrane microdomains

21 January 2018

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Floating the raft hypothesis: lipid rafts play a role in immune cell activation

21 January 2018

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Membrane compartmentation is required for efficient T cell activation.

21 January 2018

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The T cell receptor for antigen: signaling and ligand discrimination

21 January 2018

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Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization

21 January 2018

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Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

21 January 2018

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Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation

21 January 2018

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Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

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Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

21 January 2018

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Molecular basis of T cell inactivation by CTLA-4

21 January 2018

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Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

21 January 2018

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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

21 January 2018

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Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A

21 January 2018

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Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function

21 January 2018

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Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation.

21 January 2018

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Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.

21 January 2018

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Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

21 January 2018

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CD28-independent costimulation of T cells in alloimmune responses.

21 January 2018

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CTLA-4 up-regulation plays a role in tolerance mediated by CD45.

21 January 2018

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CTLA-4-Ig regulates tryptophan catabolism in vivo.

21 January 2018

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CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment

21 January 2018

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Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size

21 January 2018

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CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade

21 January 2018

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Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).

21 January 2018

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Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4.

21 January 2018

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Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation

21 January 2018

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Regulation of protein kinase cascades by protein phosphatase 2A.

21 January 2018

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https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

CD28 function: a balance of costimulatory and regulatory signals

21 January 2018

2 references

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

21 January 2018

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

Cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibits CD28-induced IkappaBalpha degradation and RelA activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

Immunology. The immunological synapse--a multitasking system

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

21 January 2018

2 references

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

21 January 2018

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

The immunological synapse: required for T cell receptor signalling or directing T cell effector function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

T lymphocyte costimulation mediated by reorganization of membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

Polarization of naive CD4+ T cells toward the Th1 subset by CTLA-4 costimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

Activation and inhibition of lymphocytes by costimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

CTLA-4 ligation blocks CD28-dependent T cell activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

CD28 Signaling via VAV/SLP-76 Adaptors

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

The CD28 signaling pathway regulates glucose metabolism

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-6143.2003.00182.X

7 January 2021

10.1034/J.1600-6143.2003.00182.X

Identifiers

DOI

1 reference

6 August 2017

1 reference