(Q35181795)

7 August 2017

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title

Microtubule-interacting drugs for cancer treatment (English)

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7 August 2017

Paula M Checchi

1

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7 August 2017

James H Nettles

2

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7 August 2017

Jun Zhou

3

1 reference

7 August 2017

James P Snyder

4

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7 August 2017

Harish C Joshi

5

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7 August 2017

1 July 2003

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Trends in Pharmacological Sciences

7 August 2017

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7 August 2017

24

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7 August 2017

7

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7 August 2017

361-365

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To cycle or not to cycle: a critical decision in cancer.

7 August 2017

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Segregating sister genomes: the molecular biology of chromosome separation

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Chromosome segregation and cancer: cutting through the mystery

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Cell-cycle dysregulation and anticancer therapy

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Mechanism-based target identification and drug discovery in cancer research

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Past and future of the mitotic spindle as an oncology target

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Anticancer therapy with novel tubulin-interacting drugs

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Structural insights into microtubule function

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

1 reference

7 January 2021

Microtubule polymerization dynamics

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Microtubule treadmilling: what goes around comes around

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

The use and action of drugs in analyzing mitosis

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Physiochemical aspects of tubulin-interacting antimitotic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Stabilization of microtubule dynamics by estramustine by binding to a novel site in tubulin: a possible mechanistic basis for its antitumor action

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Cryptophycins: a novel class of potent antimitotic antitumor depsipeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

High-resolution model of the microtubule

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Location and properties of the taxol binding center in microtubules: a picosecond laser study with fluorescent taxoids

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Epothilones: a novel class of non-taxane microtubule-stabilizing agents

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Microtubule-stabilizing agents: a growing class of important anticancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Novel molecules that interact with microtubules and have functional activity similar to Taxol

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Multidrug resistance: can new drugs help chemotherapy score against cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

A beta-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Tubulin isotypes and the multigene tubulin families

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Diversity among tubulin subunits: toward what functional end?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

Preparation of a monoclonal antibody specific for the class I isotype of beta-tubulin: the beta isotypes of tubulin differ in their cellular distributions within human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900161-5

7 January 2021

10.1016/S0165-6147(03)00161-5

Identifiers

DOI

1 reference

7 August 2017

1 reference