(Q35215414)

7 August 2017

1 reference

title

An Alzheimer's disease hypothesis based on transcriptional dysregulation (English)

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transcriptional dysregulation

7 August 2017

0 references

1 reference

Nikolaos K Robakis

1

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7 August 2017

1 June 2003

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7 August 2017

1 reference

7 August 2017

10

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7 August 2017

2

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7 August 2017

80-85

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Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

7 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Involvement of amyloid as a central step in the development of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Alzheimer's disease: a re-examination of the amyloid hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Arson. Tracking the culprit in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Abeta as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Regenerative failure: a potential mechanism for neuritic dystrophy in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Alzheimer neuropathologic alterations in aged cognitively normal subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

The effects of age, apolipoprotein E phenotype and gender on the concentration of amyloid-beta (A beta) 40, A beta 4242, apolipoprotein E and transthyretin in human cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Combination assay of CSF tau, A beta 1-40 and A beta 1-42(43) as a biochemical marker of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

The relative frequency of "dementia of unknown etiology" increases with age and is nearly 50% in nonagenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Neurodegeneration. A glutamine-rich trail leads to transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13506120309041729

10.3109/13506120309041729

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12964415